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Author Details

Stuart H Orkin
Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School
1967
641
180
PMIDPaper TitleJournal TitlePublished Year
36670102Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors.Nat Commun2023
37833630Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC.BMC Genomics2023
38042929Role of PDGFRA<sup>+</sup> cells and a CD55<sup>+</sup> PDGFRA<sup>Lo</sup> fraction in the gastric mesenchymal niche.Nat Commun2023
36993171Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops.bioRxiv2023
37386251Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.Nat Genet2023
37428871In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice.Blood Adv2023
37162846Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC.Res Sq2023
36626555Evolution of nanobodies specific for BCL11A.Proc Natl Acad Sci U S A2023
36907604Fetal Hemoglobin Regulation in Beta-Thalassemia.Hematol Oncol Clin North Am2023
36798304Defining the structure, signals, and cellular elements of the gastric mesenchymal niche.bioRxiv2023
36798304Defining the structure, signals, and cellular elements of the gastric mesenchymal niche.bioRxiv2023
36764753High-efficiency knock-in of degradable tags (dTAG) at endogenous loci in cell lines.Methods Enzymol2023
34969824Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.Genes Dev2022
35709529Transcriptional Plasticity Drives Leukemia Immune Escape.Blood Cancer Discov2022
35476984Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells.Cell Rep2022
35839780Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells.Cell Chem Biol2022
35405016Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.Cancer Discov2022
35714596CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells.Stem Cell Reports2022
35385744Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.Cell Rep2022
36589886A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin.ACS Cent Sci2022
34168132Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2.Nat Commun2021
33649594Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nat Genet2021
33731942Author Correction: Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nat Genet2021
33688634MOLECULAR MEDICINE: Found in Translation.Med2021
34529935Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.Cell Stem Cell2021
34526084Mapping the evolving landscape of super-enhancers during cell differentiation.Genome Biol2021
34404810A unified model of human hemoglobin switching through single-cell genome editing.Nat Commun2021
34716321Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.Nat Commun2021
34290235Reactivation of a developmentally silenced embryonic globin gene.Nat Commun2021
32138752Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9.Genome Biol2020
32025033Live-animal imaging of native haematopoietic stem and progenitor cells.Nature2020
31959994Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation.Nat Genet2020
33454011ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.J Biol Chem2020
32994224A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies <i>cis-</i> and <i>trans-</i>regulatory elements of <i>Oct4</i> in murine ESCs.J Biol Chem2020
32817427Enhancer dependence of cell-type-specific gene expression increases with developmental age.Proc Natl Acad Sci U S A2020
32413320An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells.Cell2020
30355263Emerging Genetic Therapy for Sickle Cell Disease.Annu Rev Med2019
31500663CUT&amp;RUNTools: a flexible pipeline for CUT&amp;RUN processing and footprint analysis.Genome Biol2019
31253978Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.Nat Genet2019
31391581BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.Nature2019
31005419TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.Mol Cell2019
30905509Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA.Mol Cell2019
29193029Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.Br J Haematol2018
30080881Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.PLoS Biol2018
30254371Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment.Sci Rep2018
29849139Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.Nature2018
30366982FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.J Biol Chem2018
30566873Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.Cell Rep2018
30561326Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation.Elife2018
30504875CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.Nat Methods2018
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Tak W Mak
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Arthur L Beaudet
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Allan Bradley
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Mario R Capecchi
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Collaborators

Guo-Cheng Yuan
Dana-Farber Cancer Institute, Harvard School of Public Health
Co-authored papers 42
Daniel E Bauer
Co-authored papers 37
Vijay G Sankaran
Co-authored papers 25
Luca Pinello
Co-authored papers 24
Huafeng Xie
South China University of Technology
Co-authored papers 22
Jonghwan Kim
Co-authored papers 17
Stylianos E Antonarakis
Co-authored papers 17
George Q Daley
Boston Children's Hospital, Harvard Medical School
Co-authored papers 15
Mitchell J Weiss
Co-authored papers 13
Marc A Kerenyi
Boston Children's Hospital, Harvard Medical School
Co-authored papers 12
Jianlong Wang
Co-authored papers 11
David M Dorfman
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 11
David Ginsburg
University of Michigan ann arbor
Co-authored papers 10
Guillaume Lettre
Co-authored papers 9
Carl R Walkley
Co-authored papers 9
Peter E Newburger
Co-authored papers 8
Qian Zhu
Boston Children's Hospital
Co-authored papers 8
Tucker Collins
Drexel University
Co-authored papers 8
Charles W M Roberts
Co-authored papers 7
Corinne Boehm
Johns Hopkins University School of Medicine
Co-authored papers 7
Konrad Hochedlinger
Co-authored papers 7
John A Stamatoyannopoulos
Altius Institute for Biomedical Sciences
Co-authored papers 6
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 6
James Palis
Co-authored papers 5
Scott A Armstrong
Boston Children's Hospital
Co-authored papers 5
Heather M Rooke
Broad Institute of Harvard and MIT
Co-authored papers 5
Sergei G Tevosian
University of Florida College of Veterinary Medicine
Co-authored papers 5
Mareike Simon
Abramson Family Cancer Research Institute, Perelman School of Medicine
Co-authored papers 5
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 5
Joel N Hirschhorn
Broad Institute of MIT and Harvard
Co-authored papers 5
Release 1.2