Author details

Full Name

Joshua P Lewis

Affiliation

ORCID

Career Start Year

2007

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37046083	Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.	Nature	2023
37745480	Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) Consortium.	bioRxiv	2023
37905118	Determinants of mosaic chromosomal alteration fitness.	medRxiv	2023
37904051	Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing.	Nat Genet	2023
37398003	Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.	medRxiv	2023
37126548	The genetic determinants of recurrent somatic mutations in 43,693 blood genomes.	Sci Adv	2023
34553764	Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.	Hum Mol Genet	2022
36481753	Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.	Nat Commun	2022
34582791	Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.	Am J Hum Genet	2021
33887194	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
34087167	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
31504375	Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients.	Eur Heart J Cardiovasc Pharmacother	2020
31883642	Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.	Am J Hum Genet	2020
32472697	Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium.	Clin Pharmacol Ther	2020
32562573	Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.	Clin Pharmacol Ther	2020
29185836	Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.	Platelets	2019
30553757	Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.	J Clin Lipidol	2019
29653637	Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).	Am Heart J	2018
29615455	Implementation of Genotype-Guided Antiplatelet Therapy: Feasible but Not Without Obstacles.	Circulation. Genomic and precision medicine	2018
28207573	Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.	Pharmacogenet Genomics	2017
28820077	Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis.	Curr Pharm Des	2017
28815128	A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records.	AMIA Jt Summits Transl Sci Proc	2017
28533733	Tobacco Smoke Exposure Reduces Paraoxonase Activity in a Murine Model.	International Journal of Biomedical Science (discontinued)	2017
29074945	Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology.	Nat Genet	2017
28075528	Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.	Clin Transl Sci	2017
27649515	Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies.	Clin Pharmacol Ther	2017
27557470	Identifying clinically relevant sources of variability: The clopidogrel challenge.	Clin Pharmacol Ther	2017
27605514	Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis.	G3: Genes, Genomes, Genetics	2016
27416945	Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.	Diabetes	2016
27412988	From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases.	G3 (Bethesda)	2016
26524713	Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.	Eur J Pharm Sci	2016
26374108	The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.	Curr Vasc Pharmacol	2016
27799230	Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation.	J Am Heart Assoc	2016
26019129	CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study.	J Am Heart Assoc	2015
25897256	Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.	Pharmgenomics Pers Med	2015
26406321	Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.	PLoS One	2015
26173871	The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.	Expert Opin Drug Metab Toxicol	2015
26504148	Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.	J Am Heart Assoc	2015
25029353	Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.	CPT Pharmacometrics Syst Pharmacol	2014
23392654	Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.	Circ Cardiovasc Genet	2013
23809542	The CYP2C19*17 variant is not independently associated with clopidogrel response.	J Thromb Haemost	2013
23892404	Integration of pharmacometabolomic and pharmacogenomic approaches reveals novel insights into antiplatelet therapy.	Clinical Pharmacology and Therapeutics	2013
23839601	Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.	Clin Pharmacol Ther	2013
23111421	The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.	Pharmacogenet Genomics	2013
22238593	A genome-wide association search for type 2 diabetes genes in African Americans.	PLoS One	2012
22511706	Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?	Circ Cardiovasc Genet	2012
21881565	Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.	Clin Pharmacol Ther	2011
21150874	A genome-wide association study for diabetic nephropathy genes in African Americans.	Kidney Int	2011
21918509	Pharmacogenomics: application to the management of cardiovascular disease.	Clin Pharmacol Ther	2011
20650312	Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.	Genomics	2010