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Author Details

Allan Bradley
The Wellcome Trust Sanger Institute
1966
326
121
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36950387<i>In vivo</i> interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.Cell Genom2023
35701408Cas9-induced large deletions and small indels are controlled in a convergent fashion.Nat Commun2022
35802654Development and application of a next-generation sequencing protocol and bioinformatics pipeline for the comprehensive analysis of the canine immunoglobulin repertoire.PLoS One2022
34282029Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer.Cancer Discov2021
33753502Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.Proc Natl Acad Sci U S A2021
34352207METTL1-mediated m[7]G modification of Arg-TCT tRNA drives oncogenic transformation.Mol Cell2021
34301766<i>miR-200</i> deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts.Genes Dev2021
32150583Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.PLoS Pathog2020
32084343FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.Cell2020
31929527High-throughput discovery of genetic determinants of circadian misalignment.PLoS Genet2020
32661121Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies.Infect Immun2020
32799926Correction to: PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.Genome Biol2020
32811551CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets.Genome Biol2020
30622252ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.Nat Commun2019
31186273NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia.Blood2019
31594818A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating <i>Salmonella</i> Infection.mBio2019
30926791PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.Nat Commun2019
30905739Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.Stem Cell Reports2019
30543000PiggyBac Transposon-Based Insertional Mutagenesis in Mice.Methods Mol Biol2019
28924718Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.Immunogenetics2018
30188522Erratum: Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.Nat Biotechnol2018
30089924Inter-homologue repair in fertilized human eggs?Nature2018
30010673Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.Nat Biotechnol2018
30568163SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.Nat Commun2018
29364867Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.Nature2018
29622784Author Correction: Revealing hidden complexities of genomic rearrangements generated with Cas9.Sci Rep2018
28868343Disentangling <i>PTEN</i>-cooperating tumor suppressor gene networks in cancer.Mol Cell Oncol2017
28079877Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.Nat Protoc2017
28319090A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.Nat Genet2017
28318489Deletion of the <i>MAD2L1</i> spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Elife2017
28993641Revealing hidden complexities of genomic rearrangements generated with Cas9.Sci Rep2017
29146922Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.Nat Commun2017
29026089A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.Nat Commun2017
29144450Corrigendum: High-throughput discovery of novel developmental phenotypes.Nature2017
28650483Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.Nat Genet2017
28835438Molecular synergy underlies the co-occurrence patterns and phenotype of <i>NPM1</i>-mutant acute myeloid leukemia.Blood2017
28533524Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.Sci Rep2017
27054363Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.PLoS Genet2016
27608668Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.Science2016
27626380High-throughput discovery of novel developmental phenotypes.Nature2016
27478939C13orf31 (FAMIN) is a central regulator of immunometabolic function.Nat Immunol2016
27558554Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.EMBO J2016
27246460Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.Genome Biol2016
26916719Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.Nat Commun2016
26742453Chromosome engineering in zygotes with CRISPR/Cas9.Genesis2016
25378133Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.Genesis2015
26546038High-density P300 enhancers control cell state transitions.BMC Genomics2015
26508638CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.Proc Natl Acad Sci U S A2015
26140595A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.Cell2015
25485836A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.Nat Genet2015
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Peter D'Eustachio
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Stuart H Orkin
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William J Pavan
National Human Genome Research Institute, National Institutes of Health
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Collaborators

Lawrence A Donehower
Baylor College of Medicine
Co-authored papers 25
David J Adams
Wellcome Sanger Institute
Co-authored papers 24
Kosuke Yusa
Wellcome Sanger Institute
Co-authored papers 16
William C Skarnes
Wellcome Trust Sanger Institute
Co-authored papers 13
Nathalie Conte
The Wellcome Trust Sanger Institute
Co-authored papers 13
Monica J Justice
The Hospital for Sick Children
Co-authored papers 12
Arthur L Beaudet
Baylor College of Medicine
Co-authored papers 9
Kent C Lloyd
University of California davis
Co-authored papers 8
Martin Hrab?? de Angelis
German Center for Diabetes Research (DZD e.V.)
Co-authored papers 8
Jacqueline K White
Wellcome Trust Sanger Institute
Co-authored papers 7
Yann Herault
Institut Clinique de la Souris (ICS), Universite de Strasbourg, CNRS, INSERM
Co-authored papers 7
Steve D M Brown
Mary Lyon Centre Harwell Science and Innovation Campus Oxfordshire UK.
Co-authored papers 7
Jane Rogers
The Wellcome Trust Sanger Institute
Co-authored papers 7
Wei-Wen Cai
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Co-authored papers 7
Wolfgang Wurst
Institute of Developmental Genetics, German Research Center for Environmental Health
Co-authored papers 6
Mark Moore
Co-authored papers 6
Gerard Karsenty
Co-authored papers 6
Colin McKerlie
The Hospital for Sick Children
Co-authored papers 6
Oliver M Dovey
Co-authored papers 6
Glauco P Tocchini-Valentini
Monterotondo Mouse Clinic (MMC), Italian National Research Council (CNR)
Co-authored papers 6
Ann-Marie Mallon
The Turing Institute
Co-authored papers 6
Terrence F Meehan
European Bioinformatics Institute
Co-authored papers 5
Xiang Gao
Nanjing Biomedical Research Institute, Nanjing University
Co-authored papers 5
Sara Wells
Mary Lyon Centre at Medical Research Council
Co-authored papers 5
Paul Flicek
European Bioinformatics Institute
Co-authored papers 5
Ann M Flenniken
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 5
Helen Parkinson
European Bioinformatics Institute
Co-authored papers 5
Patrick J Biggs
Co-authored papers 5
Lauryl M J Nutter
The Hospital for Sick Children
Co-authored papers 5
Jeremy Mason
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 5
Release 1.2