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Author Details

Gen Wen
2003
32
19
PMIDPaper TitleJournal TitlePublished Year
36138932Biomarker Genes Discovery of Alzheimer's Disease by Multi-Omics-Based Gene Regulatory Network Construction of Microglia.Brain Sciences2022
23149563Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.J Hypertens2013
24391727Heritable influence of DBH on adrenergic and renal function: twin and disease studies.PLoS One2013
21918574Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins.Am J Hypertens2012
21551321Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype.Circ Cardiovasc Genet2011
21104344Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension.Curr Hypertens Rep2011
20814407Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.Am J Hypertens2011
20204374Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.Mamm Genome2010
21061160Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.Cell Mol Neurobiol2010
20009769Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.J Hypertens2010
19820027Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.J Clin Endocrinol Metab2009
28199513Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo.Endocr Rev2009
18235090Chromogranin A polymorphisms are associated with hypertensive renal disease.J Am Soc Nephrol2008
19120120Adrenergic polymorphism and the human stress response.Ann N Y Acad Sci2008
19017515Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.J Am Coll Cardiol2008
18432188Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.Kidney Int2008
17718510Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.Biochemistry2007
17698732Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.Circulation2007
17211240C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.J Hypertens2007
17584765An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.Hum Mol Genet2007
17353515Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism.Hypertension2007
17438154Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.Circulation2007
17438153Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.Circulation2007
17026486Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin.Diabetes Obes Metab2006
16164626Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].Kidney Int2005
15920038Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.Hypertension2005
15956083Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism.J Clin Endocrinol Metab2005
14740315Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology.Am J Hum Genet2004
15326220The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses.Mol Pharmacol2004
15514066Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice.Genetics2004
14744289Gene microarray analysis of human brain arteriovenous malformations.Neurosurgery2004
12649522Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations.Stroke2003
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