Author details

Full Name

Christopher D Brown

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35059821	Uncovering Active Bacterial Symbionts in Three Species of Pollen-feeding Beetles (Nitidulidae: Meligethinae).	Microbial Ecology	2023
36829244	The genetic and evolutionary basis of gene expression variation in East Africans.	Genome Biol	2023
37165871	Evaluating the Contribution of Cell Type-Specific Alternative Splicing to Variation in Lipid Levels.	Circ Genom Precis Med	2023
34978147	Identifying differential regulatory control of APOE É¿4 on African versus European haplotypes as potential therapeutic targets.	Alzheimers Dement	2022
35710981	Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.	Nat Genet	2022
35654975	A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.	Nat Genet	2022
33499903	Exploiting the GTEx resources to decipher the mechanisms at GWAS loci.	Genome Biol	2021
33798443	A catalog of GWAS fine-mapping efforts in autoimmune disease.	American Journal of Human Genetics	2021
33901295	Functional Characterization of Organoids Derived From Irreversibly Damaged Liver of Patients With NASH.	Hepatology	2021
33998598	Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.	J Clin Invest	2021
33441424	Kidney disease genetic risk variants alter lysosomal beta-mannosidase (<i>MANBA</i>) expression and disease severity.	Sci Transl Med	2021
32912314	sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression.	Genome Biol	2020
31917787	Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.	PLoS Genet	2020
33045005	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.	PLoS Genet	2020
31488567	Genomic architecture of Shh-dependent cochlear morphogenesis.	Development (Cambridge)	2019
31561366	Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants.	Journal of Alzheimer's Disease	2019
29987113	Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans.	Circ Genom Precis Med	2018
29028988	QuASAR-MPRA: accurate allele-specific analysis for massively parallel reporter assays.		2018
30315151	Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree.	Transl Psychiatry	2018
30113658	INFERNO: inferring the molecular mechanisms of noncoding genetic variants.	Nucleic Acids Research	2018
30254052	High-throughput characterization of genetic effects on DNA-protein binding and gene transcription.	Genome Research	2018
29914366	Transposable elements generate regulatory novelty in a tissue-specific fashion.	BMC Genomics	2018
30275566	Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.	Nat Med	2018
28263985	Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression.	PLoS Genet	2017
28388432	Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.	Cell Stem Cell	2017
28855262	Transposable elements are the primary source of novelty in primate gene regulation.	Genome Res	2017
28942964	Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.	Am J Hum Genet	2017
28575649	Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.	Am J Hum Genet	2017
29056226	A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.	Am J Hum Genet	2017
29022597	Genetic effects on gene expression across human tissues.	Nature	2017
27906975	Bringing PLOS Genetics Editors to Preprint Servers.	PLoS Genet	2016
27467526	Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.	PLoS Computational Biology	2016
26576852	Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.	Mol Biol Evol	2016
27956632	Increased burden of deleterious variants in essential genes in autism spectrum disorder.	Proceedings of the National Academy of Sciences of the United States of America	2016
27508872	Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.	Cell Metab	2016
25056374	Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.	Clin Cancer Res	2015
25492084	Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes.	Clin Cancer Res	2015
25662214	Autonomous actions of the human growth hormone long-range enhancer.	Nucleic Acids Research	2015
25361180	A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.	Journal of Clinical Endocrinology and Metabolism	2015
25648650	Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.	Nat Commun	2015
25255959	Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma.	Oral Oncol	2015
26044351	Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster.	Molecular Biology and Evolution	2015
26418766	Diving deeper to predict noncoding sequence function.	Nature Methods	2015
25087611	Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.	Am J Hum Genet	2014
24625924	Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.	PLoS Genet	2014
24890684	Low-grade prostate cancer diverges early from high grade and metastatic disease.	Cancer Science	2014
24931631	The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).	British Journal of Haematology	2014
23212519	CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.	Blood	2013
23995691	A statin-dependent QTL for GATM expression is associated with statin-induced myopathy.	Nature	2013
23935528	Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.	PLoS Genet	2013