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Author Details

Alan Mackay-Sim
Northern Clinical School, Sydney Medical School, University of Sydney
1980
169
60
PMIDPaper TitleJournal TitlePublished Year
37144097Reduced acetylated α-tubulin in <i>SPAST</i> hereditary spastic paraplegia patient PBMCs.Front Neurosci2023
35203328Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer's Disease Patients.Cells2022
36291125An Alzheimer's Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition.Cells2022
34507142Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations.Stem Cell Res2021
33841129Novel <i><i>STMN2</i></i> Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype.Front Aging Neurosci2021
33810178Hereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery.Brain Sci2021
34502103Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.Int J Mol Sci2021
34404843Single cell morphology distinguishes genotype and drug effect in Hereditary Spastic Paraplegia.Sci Rep2021
34459078Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids.Aging Cell2021
32457567Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia <i>SPAST</i> Patient Neurons.Front Neurosci2020
32639142Antibody-Free Targeted Proteomics Assay for Absolute Measurement of α-Tubulin Acetylation.Anal Chem2020
32973427Mitochondrial Function in Hereditary Spastic Paraplegia: Deficits in <i>SPG7</i> but Not <i>SPAST</i> Patient-Derived Stem Cells.Front Neurosci2020
32487172Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.Part Fibre Toxicol2020
30065201Patient-Derived Stem Cell Models in <i>SPAST</i> HSP: Disease Modelling and Drug Discovery.Brain Sci2018
30094183Expanding the spectrum of <i>PEX16</i> mutations and novel insights into disease mechanisms.Mol Genet Metab Rep2018
28850106FANTOM5 CAGE profiles of human and mouse samples.Sci Data2017
28477134A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia.Methods Mol Biol2017
28286248Cell migration in schizophrenia: Patient-derived cells do not regulate motility in response to extracellular matrix.Mol Cell Neurosci2017
28560252DNA methylation in schizophrenia in different patient-derived cell types.NPJ Schizophr2017
27574816Olfactory ensheathing cells but not fibroblasts reduce the duration of autonomic dysreflexia in spinal cord injured rats.Auton Neurosci2016
26432933Isolating dividing neural and brain tumour cells for gene expression profiling.J Neurosci Methods2016
27602387Schizophrenia patient-derived olfactory neurosphere-derived cells do not respond to extracellular reelin.NPJ Schizophr2016
27123847Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson's Disease.PLoS One2016
27447544A Grand Challenge. 2. Phenotypic Profiling of a Natural Product Library on Parkinson's Patient-Derived Cells.J Nat Prod2016
27229699Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia.Sci Rep2016
25557046Labeling of Cellular DNA with a Cyclosal Phosphotriester Pronucleotide Analog of 5-ethynyl-2'-deoxyuridine.Chem Biol Drug Des2015
26438696A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations.Dis Model Mech2015
26485546Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.Transl Psychiatry2015
26485547Reduced protein synthesis in schizophrenia patient-derived olfactory cells.Transl Psychiatry2015
24399444Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction.Hum Mol Genet2014
26484151Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern.Genom Data2014
25278572Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion.Clin Microbiol Rev2014
24836764An acute growth factor treatment that preserves function after spinal cord contusion injury.J Neurotrauma2014
24736221Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis.mBio2014
24857849Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Biol Open2014
24670764A promoter-level mammalian expression atlas.Nature2014
23264559A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations.Dis Model Mech2013
24144420Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells.Part Fibre Toxicol2013
23861879Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.PLoS One2013
23934846Clinical trials for the treatment of spinal cord injury: not so simple.Methods Mol Biol2013
23934838Isolation of adult stem cells from the human olfactory mucosa.Methods Mol Biol2013
23474819A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.Hum Mol Genet2013
23415759Phagocytosis of bacteria by olfactory ensheathing cells and Schwann cells.Neurosci Lett2013
23482246Focal adhesion dynamics are altered in schizophrenia.Biol Psychiatry2013
23543597Patient-derived stem cells: pathways to drug discovery for brain diseases.Front Cell Neurosci2013
23238039Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice.Behav Brain Res2013
21568693Combined VEGF and PDGF treatment reduces secondary degeneration after spinal cord injury.J Neurotrauma2012
23197870Variability in the generation of induced pluripotent stem cells: importance for disease modeling.Stem Cells Transl Med2012
23024784Leukaemia inhibitory factor stimulates proliferation of olfactory neuronal progenitors via inducible nitric oxide synthase.PLoS One2012
22961669Concise review: Patient-derived olfactory stem cells: new models for brain diseases.Stem Cells2012
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Collaborators

Ernst J Wolvetang
Australian Institute for Bioengineering and Nanotechnology, University of Queensland
Co-authored papers 7
Christine A Wells
The University of Melbourne
Co-authored papers 7
Anthony G Beckhouse
Bio-Rad Laboratories Pty Ltd
Co-authored papers 3
Tony J Kenna
Queensland University of Technology
Co-authored papers 2
Thierry Sengstag
University of Basel
Co-authored papers 2
Hiroshi Ohno
RIKEN Center for Integrative Medical Sciences
Co-authored papers 2
Dan Goldowitz
University of British Columbia
Co-authored papers 2
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Shigeo Koyasu
RIKEN Center for Integrative Medical Sciences (IMS)
Co-authored papers 2
Michael Detmar
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 2
Peter Zhang
Child and Family Research Institute, University of British Columbia
Co-authored papers 2
Naoto Kondo
Nagoya City University Graduate School of Medical Sciences
Co-authored papers 2
Takaaki Sugiyama
Co-authored papers 2
Jun Furusawa
Aichi Cancer Center Hospital
Co-authored papers 2
Guojun Sheng
International Research Center for Medical Sciences (IRCMS), Kumamoto University
Co-authored papers 2
Yosuke Mizuno
Yokohama National University
Co-authored papers 2
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 2
Stefano Gustincich
Istituto Italiano di Tecnologia
Co-authored papers 2
Yuki I Kawamura
Research Institute, National Center for Global Health and Medicine
Co-authored papers 2
Reto Guler
International Centre for Genetic Engineering and Biotechnology
Co-authored papers 2
Albert S B Edge
Harvard Medical School
Co-authored papers 2
Christophe Simon
RIKEN Yokohama Institute
Co-authored papers 2
Peter Heutink
German Center for Neurodegenerative Diseases (DZNE).
Co-authored papers 2
Suzana Savvi
South African Medical Research Council (SAMRC), University of Cape Town
Co-authored papers 2
Soichi Ogishima
Tohoku University Graduate School of Medicine
Co-authored papers 2
Christine L Mummery
Leiden University Medical Center
Co-authored papers 2
Weonju Lee
Kyungpook National University, Kyungpook National University Hospital
Co-authored papers 2
Yohei Yonekura
RIKEN Center for Developmental Biology
Co-authored papers 2
Carsten O Daub
International Institute of Molecular and Cell Biology in Warsaw
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Release 1.2