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Author Details

Andrea Bertotti
Candiolo Cancer Institute - FPO IRCCS
2000
85
40
PMIDPaper TitleJournal TitlePublished Year
36862005MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis.Mol Oncol2023
37585503Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer.Sci Transl Med2023
37189167Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity.Genome Med2023
37079732CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.Bioinformatics2023
37063647EGAsubmitter: A software to automate submission of nucleic acid sequencing data to the European Genome-phenome Archive.Front Bioinform2023
36622698Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.Clin Cancer Res2023
36759506Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT).Cell Death Dis2023
34635836Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin.Nat Biotechnol2022
35817983A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.Nat Genet2022
35197630Effective drug combinations in breast, colon and pancreatic cancer cells.Nature2022
34359705Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways.Cancers (Basel)2021
33795873Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.Nat Cell Biol2021
34426441Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.Clin Cancer Res2021
34217219PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity.BMC Bioinformatics2021
34074330Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer.J Exp Clin Cancer Res2021
32430388EGFR Blockade Reverts Resistance to KRAS<sup>G12C</sup> Inhibition in Colorectal Cancer.Cancer Discov2020
33066609Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models.Cancers (Basel)2020
32759276Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.Sci Transl Med2020
32700762Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.Int J Cancer2020
32183295Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer.Cancers (Basel)2020
30698777One tool to find them all: a case of data integration and querying in a distributed LIMS platform.Database (Oxford)2019
31813455Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga.Trends Cancer2019
31699882Adaptive mutability of colorectal cancers in response to targeted therapies.Science2019
31375513Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.Clin Cancer Res2019
31287543Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research.Database (Oxford)2019
31253177Evolving neoantigen profiles in colorectal cancers with DNA repair defects.Genome Med2019
31126969INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.Mol Syst Biol2019
30979792INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.Mol Syst Biol2019
30971826Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.Nature2019
31164152Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models.J Exp Clin Cancer Res2019
28974546A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.Clin Cancer Res2018
29990497Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.Cancer Cell2018
29574251Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.Neoplasia2018
29538669RET fusions in a small subset of advanced colorectal cancers at risk of being neglected.Ann Oncol2018
28561063Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.Nat Commun2017
28104906Interrogating open issues in cancer precision medicine with patient-derived xenografts.Nat Rev Cancer2017
29092942PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.Cancer Res2017
28912576Interrogating open issues in cancer medicine with patient-derived xenografts.Nat Rev Cancer2017
27108243Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.Lancet Oncol2016
27681291Corrigendum: Stromal contribution to the colorectal cancer transcriptome.Nat Genet2016
27771609Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.J Natl Cancer Inst2016
27708224A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors.Oncotarget2016
27149858Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity.J Transl Med2016
26843189MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.Sci Transl Med2016
26787475Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.BMC Biol2016
25706627Stromal contribution to the colorectal cancer transcriptome.Nat Genet2015
26272063MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.Clin Cancer Res2015
26243863HER2 activating mutations are targets for colorectal cancer treatment.Cancer Discov2015
26296355Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.Clin Cancer Res2015
26420058A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells.Sci Rep2015
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Collaborators

Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 72
Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS
Co-authored papers 26
Co-authored papers 15
Royal College of Surgeons in Ireland (RCSI)
Co-authored papers 5
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 3
Netherlands Cancer Institute
Co-authored papers 3
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 3
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus
Co-authored papers 3
CNRS URA 5
Co-authored papers 3
CRUK Cambridge Institute, University of Cambridge
Co-authored papers 3
Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 3
University of Cambridge
Co-authored papers 3
Co-authored papers 3
Netherlands Cancer Institute
Co-authored papers 3
Netherlands Cancer Institute
Co-authored papers 3
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 3
Wellcome Sanger Institute
Co-authored papers 3
Co-authored papers 2
University of Turin, Candiolo Cancer Institute, FPO-IRCCS
Co-authored papers 2
University Medical Centre Mannheim, University of Heidelberg
Co-authored papers 2
European Institute of Oncology IRCCS
Co-authored papers 2
Co-authored papers 2
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 1
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 1
Imperial College London
Co-authored papers 1
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Dana-Farber Cancer Institute
Co-authored papers 1
Hopp Children's Cancer Center (KiTZ)
Co-authored papers 1
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 1