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Author Details

Ulrich Auf dem Keller
Technical University of Denmark
2002
82
35
PMIDPaper TitleJournal TitlePublished Year
36102354New links for meprin β within the protease web.FEBS J2023
37665457Sensitive and High-Throughput Exploration of Protein N-Termini by TMT-TAILS N-Terminomics.Methods Mol Biol2023
37639361Assessing the Role of Trypsin in Quantitative Plasma and Single-Cell Proteomics toward Clinical Application.Anal Chem2023
37602921Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors.Int J Cancer2023
37253089The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.Sci Signal2023
37336268ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation.Matrix Biol2023
36920550Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome.Cell Mol Life Sci2023
36864079TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression.NPJ Breast Cancer2023
36729833Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.Cell Rep2023
36108803Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis.J Invest Dermatol2023
34547431Effective protein extraction combined with data independent acquisition analysis reveals a comprehensive and quantifiable insight into the proteomes of articular cartilage and subchondral bone.Osteoarthritis Cartilage2022
36250733Longitudinal Evaluation of Biomarkers in Wound Fluids from Venous Leg Ulcers and Split-thickness Skin Graft Donor Site Wounds Treated with a Protease-modulating Wound Dressing.Acta Derm Venereol2022
36280126Degradomics technologies in matrisome exploration.Matrix Biol2022
36309071Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom.Toxicon2022
35998057ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion.JCI Insight2022
33246101Distinct extracellular-matrix remodeling events precede symptoms of inflammation.Matrix Biol2021
33727531Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen.Nat Commun2021
33636276Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom.Int J Biol Macromol2021
34099695Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.Nat Commun2021
33220627New strategies to identify protease substrates.Curr Opin Chem Biol2021
31463921Mapping the N-Terminome in Tissue Biopsies by PCT-TAILS.Methods Mol Biol2020
32087360Combinatorial degradomics: Precision tools to unveil proteolytic processes in biological systems.Biochim Biophys Acta Proteins Proteom2020
32012358Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome.J Intern Med2020
31917255Tendon response to matrix unloading is determined by the patho-physiological niche.Matrix Biol2020
32826880Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.Cell Death Dis2020
32283690Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?Toxins (Basel)2020
32457615Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A<sub>2</sub> and Cytotoxins.Front Pharmacol2020
32290531Matrix Metalloproteinases: How Much Can They Do?Int J Mol Sci2020
30893860Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening.Toxins (Basel)2019
31238509Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases.Int J Mol Sci2019
30840238Exploring Extracellular Matrix Degradomes by TMT-TAILS N-Terminomics.Methods Mol Biol2019
28899681Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients.J Invest Dermatol2018
29743348Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.Sci Transl Med2018
28890072Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.Dev Cell2017
28315245Multidimensional Analysis of Protease Substrates and Their Cellular Origins in Mixed Secretomes from Multiple Cell Types.Methods Mol Biol2017
28109429Body Fluid Degradomics and Characterization of Basic N-Terminome.Methods Enzymol2017
28299737Time-Resolved Analysis of Matrix Metalloproteinase Substrates in Complex Samples.Methods Mol Biol2017
28850541Targeted degradomics in protein terminomics and protease substrate discovery.Biol Chem2017
26981551Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.Data Brief2016
26407638Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.Matrix Biol2016
27477282TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.Cell Rep2016
27183581Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2-IL-36γ Pathway.J Immunol2016
25562666Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes.J Invest Dermatol2015
26475864Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions.Mol Cell Proteomics2015
25871442Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.Proteomics2015
25603365Proteomic approaches to uncover MMP function.Matrix Biol2015
25516628In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates.Mol Cell Proteomics2015
24281761Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.Mol Cell Proteomics2014
25310974Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.Cell Rep2014
22940918The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.Cell Mol Life Sci2013
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Collaborators

Christopher M Overall
University of British Columbia
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Daniel G Anderson
Co-authored papers 2
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University of Washington School of Medicine
Co-authored papers 2
Roman L Bogorad
Co-authored papers 2
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Functional Genomics Center Zurich (FGCZ)-University of Zurich/ETH Zurich
Co-authored papers 2
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University of British Columbia
Co-authored papers 1
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Co-authored papers 1
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Rodolfo Ciuffa
Institute of Molecular Systems Biology, ETH Zurich
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Therese Wohlschlager
University of Salzburg
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Vincenzo De Filippis
Department of Pharmaceutical and Pharmacological Sciences, University of Padua
Co-authored papers 1
Bernd Wollscheid
ETH Zurich
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Sandra Goetze
ETH Zurich
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Rigshospitalet, University of Copenhagen
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University of British Columbia
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Laura Acquasaliente
Department of Pharmaceutical and Pharmacological Sciences, University of Padova
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Gerhard Liebisch
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Matej Vizovi??ek
Jozef Stefan Institute
Co-authored papers 1
Blaise A Clarke
University of Toronto.
Co-authored papers 1
Nikolaus Fortelny
University of Salzburg
Co-authored papers 1
Andreas Hober
KTH Royal Institute of Technology
Co-authored papers 1
Federico Uliana
Institute of Biochemistry, ETH Zurich
Co-authored papers 1
Andrea Fossati
J. David Gladstone Institutes
Co-authored papers 1
Fabian Frommelt
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Tamar Geiger
Tel Aviv University
Co-authored papers 1
Christopher T Workman
Technical University of Denmark
Co-authored papers 1
Fredrik Edfors
KTH Royal Institute of Technology
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Matthias Gstaiger
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