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Author Details

Nicolas L Fawzi
Brown University
2003
74
34
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36690069Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies.J Mol Biol2023
38056002Liquid-Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics.J Phys Chem Lett2023
37579155A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain.Proc Natl Acad Sci U S A2023
37986933Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in <i>Xenopus</i> oocytes.bioRxiv2023
37986834Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation.bioRxiv2023
37732211Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.bioRxiv2023
37231298Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions.Nat Chem2023
36782025Phase separation in fungi.Nat Microbiol2023
34862761Reversible Kinetic Trapping of FUS Biomolecular Condensates.Adv Sci (Weinh)2022
35481648An enhancer sequence in the intrinsically disordered region of FtsZ promotes polymer-guided substrate processing by ClpXP protease.Protein Sci2022
35059438Editorial: The Role of Protein Post-Translational Modifications in Protein-RNA Interactions and RNP Assemblies.Front Mol Biosci2022
33349959Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.EMBO J2021
33547841N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma.Protein Sci2021
33582133A predictive coarse-grained model for position-specific effects of post-translational modifications.Biophys J2021
33798566Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain.Biophys J2021
33688043Membrane bending by protein phase separation.Proc Natl Acad Sci U S A2021
34759379Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads.Nat Struct Mol Biol2021
34380047TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.Cell2021
34342574CLAMP and Zelda function together to promote <i>Drosophila</i> zygotic genome activation.Elife2021
34059832Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.Nat Neurosci2021
34144468Biophysical studies of phase separation integrating experimental and computational methods.Curr Opin Struct Biol2021
34357401The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation.J Cell Sci2021
32132204TDP-43 α-helical structure tunes liquid-liquid phase separation and function.Proc Natl Acad Sci U S A2020
31911439The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy.J Biol Chem2020
33200826SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs.EMBO J2020
33078950Refining All-Atom Protein Force Fields for Polar-Rich, Prion-like, Low-Complexity Intrinsically Disordered Proteins.J Phys Chem B2020
32719507Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements.Nat Microbiol2020
32860012Elastin phase separation - structure or disorder?Nat Rev Mol Cell Biol2020
32577653SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.bioRxiv2020
32870271Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation.Nucleic Acids Res2020
30594291Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis.Neuroscience2019
31270472Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain.Nat Struct Mol Biol2019
31493925Physiological, Pathological, and Targetable Membraneless Organelles in Neurons.Trends Neurosci2019
31434643EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons.Biol Open2019
31199001Phase separation in biology and disease-a symposium report.Ann N Y Acad Sci2019
28945358Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.Biochemistry2018
29802409Protein quality and miRNA slicing get into phase.Nat Cell Biol2018
30397184The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low-complexity domain of hnRNPA2.J Biol Chem2018
29728636Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus.Sci Rep2018
29358076Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.Mol Cell2018
29438978A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.EMBO J2018
29602697Protein Phase Separation: A New Phase in Cell Biology.Trends Cell Biol2018
29764981Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.EMBO J2018
29562179Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome.Cell Rep2018
29677513Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.Cell2018
29151213Probing the Atomic Structure of Transient Protein Contacts by Paramagnetic Relaxation Enhancement Solution NMR.Methods Mol Biol2018
29272914Synthesis and Characterization of a Magnetically Active <sup>19</sup>F Molecular Beacon.Bioconjug Chem2018
28790177Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.EMBO J2017
28306503Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.Mol Cell2017
27545621ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Structure2016
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Collaborators

Co-authored papers 12
Brown University
Co-authored papers 6
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 3
VIB-VUB Center for Structural Biology
Co-authored papers 2
Broad Institute of MIT and Harvard
Co-authored papers 2
Co-authored papers 2
University of Texas Southwestern Medical Center
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
The University of Texas at Austin, USA Center for Systems and Synthetic Biology
Co-authored papers 1
Marine Biological Laboratory
Co-authored papers 1
University of Georgia
Co-authored papers 1
Lewis-Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 1
Co-authored papers 1
Wellcome Trust Sanger Institute
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children
Co-authored papers 1
Tokai University School of Medicine
Co-authored papers 1
Columbia University Irving Medical Center
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
Co-authored papers 1
Howard Hughes Medical Institute, UT Southwestern Medical Center
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
College of Life Sciences, Ritsumeikan University
Co-authored papers 1
Harvard Medical School, USA Infectious Disease Institute (P.J.M.B.
Co-authored papers 1
Co-authored papers 1
University of Massachusetts Chan Medical School
Co-authored papers 1
Medical Research Council Harwell Institute
Co-authored papers 1