Author details

Full Name

Brian Kuhlman

Affiliation

ORCID

Career Start Year

1997

Papers

165

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37034763	design of stable proteins that efficaciously inhibit oncogenic G proteins.		2023
36509904	Designer installation of a substrate recruitment domain to tailor enzyme specificity.		2023
37205527	evolution of protein binders with deep learning models for structure prediction and sequence design.		2023
36705186	Design of a protease-activated PD-L1 inhibitor.		2023
36634348	Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones.		2023
37368504	De novo design of stable proteins that efficaciously inhibit oncogenic G proteins.		2023
37547004	Transfer learning to leverage larger datasets for improved prediction of protein stability changes.		2023
35108000	Comparative Analysis of Sulfonium-Ï¿, Ammonium-Ï¿, and Sulfur-Ï¿ Interactions and Relevance to SAM-Dependent Methyltransferases.	Journal of the American Chemical Society	2022
35461160	Design and engineering of light-sensitive protein switches.	Current Opinion in Structural Biology	2022
36173174	Stabilizing proteins, simplified: A Rosetta-based webtool for predicting favorable mutations.	Protein Science	2022
35762713	AlphaFold accurately predicts distinct conformations based on the oligomeric state of a de novo designed protein.	Protein Sci	2022
35643320	A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines.	Journal of Biological Chemistry	2022
35618140	Advances in modular control of CAR-T therapy with adapter-mediated CARs.	Advanced Drug Delivery Reviews	2022
35667008	Correction to "The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design".	J Chem Theory Comput	2022
35128921	From Protein Design to the Energy Landscape of a Cold Unfolding Protein.	J Phys Chem B	2022
34652943	Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies.	Science advances	2021
33539876	Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3KÎ± and PI3KÎ³.	Journal of Molecular Biology	2021
33547226	Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling.	Cancer Immunol Res	2021
33249652	Perturbing the energy landscape for improved packing during computational protein design.	Proteins	2021
34715131	Designer proteins that competitively inhibit GÎ± by targeting its effector site.	Journal of Biological Chemistry	2021
32611757	Dimerization of Dengue Virus E Subunits Impacts Antibody Function and Domain Focus.	Journal of Virology	2020
32365137	Better together: Elements of successful scientific software development in a distributed collaborative community.	PLoS Comput Biol	2020
31887287	A Computational Protocol for Regulating Protein Binding Reactions with a Light-Sensitive Protein Dimer.	Journal of Molecular Biology	2020
32393818	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.	Nature Communications	2020
32336757	Computer-based Engineering of Thermostabilized Antibody Fragments.	AIChE J	2020
32483333	Macromolecular modeling and design in Rosetta: recent methods and frameworks.	Nat Methods	2020
32694868	Author Correction: Optogenetic control of cofilin and Î±TAT in living cells using Z-lock.	Nature Chemical Biology	2020
33020206	An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation.	Genome Res	2020
31417196	Advances in protein structure prediction and design.	Nature Reviews Molecular Cell Biology	2019
31699898	Designing protein structures and complexes with the molecular modeling program Rosetta.	Journal of Biological Chemistry	2019
31740825	Optogenetic control of cofilin and Î±TAT in living cells using Z-lock.	Nature Chemical Biology	2019
29678884	Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins.	Journal of Biological Chemistry	2018
30221938	Correction to Rapid Sampling of Hydrogen Bond Networks for Computational Protein Design.	J Chem Theory Comput	2018
29975520	Engineering a Protein Binder Specific for p38Î± with Interface Expansion.	Biochemistry	2018
30545884	Evolution of a highly active and enantiospecific metalloenzyme from short peptides.	Science	2018
30392931	A Bifunctional Role for the UHRF1Â UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.	Mol Cell	2018
30441907	Engineering Improved Photoswitches for the Control of Nucleocytoplasmic Distribution.	ACS Synth Biol	2018
29446199	Light-Dependent Cytoplasmic Recruitment Enhances the Dynamic Range of a Nuclear Import Photoswitch.	ChemBioChem	2018
29303250	We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer.	Biochemistry	2018
29259096	Control of microtubule dynamics using an optogenetic microtubule plus end-F-actin cross-linker.	Journal of Cell Biology	2018
29659276	Protocols for Requirement-Driven Protein Design in the Rosetta Modeling Program.	Journal of Chemical Information and Modeling	2018
29652499	Rapid Sampling of Hydrogen Bond Networks for Computational Protein Design.	J Chem Theory Comput	2018
29506131	Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.	Nucleic Acids Res	2018
28704043	Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.	J Am Chem Soc	2017
28430426	The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design.	J Chem Theory Comput	2017
28726352	Computational design of a specific heavy chain/Îº light chain interface for expressing fully IgG bispecific antibodies.	Protein Science	2017
28754687	Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.	Journal of Cell Science	2017
27667693	Computational Repacking of HIF-2Î± Cavity Replaces Water-Based Stabilized Core.	Structure	2016
27151863	Design of structurally distinct proteins using strategies inspired by evolution.	Science	2016
27427858	LOVTRAP: an optogenetic system for photoinduced protein dissociation.	Nature Methods	2016