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Author Details

Stephen T Keir
1994
146
48
PMIDPaper TitleJournal TitlePublished Year
37131619Interplay between and mutations governs innate immune responses in diffuse gliomas.2023
37760589Repurposing Clemastine to Target Glioblastoma Cell Stemness.Cancers (Basel)2023
36639156Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.J Immunother Cancer2023
35324138Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide.ACS Applied Bio Materials2022
35247901Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.Clin Cancer Res2022
34593527A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.Clin Cancer Res2021
31040154MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.Cancer Research2019
30625226Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.PLoS ONE2019
29703821A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.Clinical Cancer Research2018
30266879Correction: Reversing the Warburg effect as a treatment for glioblastoma.Journal of Biological Chemistry2018
30120661Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.Journal of Neuro-Oncology2018
29564747Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.Journal of Neuro-Oncology2018
29258295Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.Nature2018
27786412Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2017
28379574The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival.Neuro Oncol2017
28669010A cross sectional analysis from a single institution's experience of psychosocial distress and health-related quality of life in the primary brain tumor population.Journal of Neuro-Oncology2017
28829151Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.2017
27650817Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.Pediatr Blood Cancer2017
27496711Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis.Cancer Res2016
27238606Initial Testing (Stage 1) of MK-8242-A Novel MDM2 Inhibitor-by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2016
26797892Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2016
27160908A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.Cell Rep2016
26766590MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.Cancer Cell2016
26398108Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.Pediatr Blood Cancer2016
25986925Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies.Oncotarget2015
25500058Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program.Clin Cancer Res2015
25407467Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program.Pediatr Blood Cancer2015
25263539Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.Pediatr Blood Cancer2015
25598002Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.J Neurochem2015
26429914Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.Journal of Biological Chemistry2015
25115740Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.Journal of Neuro-Oncology2014
23956067Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2014
24038993Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2014
24722048Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.Oncotarget2014
25202981miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.Journal of Clinical Investigation2014
24623675Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program.Pediatr Blood Cancer2014
24664981Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.Pediatr Blood Cancer2014
25131802Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program.Pediatr Blood Cancer2014
23115013Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.International Journal of Cancer2013
22753001Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2013
23002019Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program.Pediatr Blood Cancer2013
23857604Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy.Clinical Cancer Research2013
23798344Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program.Pediatr Blood Cancer2013
24240169KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.Oncotarget2013
23924792Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.mAbs2013
24093630Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.Journal of Neurosurgery2013
23917401The integrated landscape of driver genomic alterations in glioblastoma.Nat Genet2013
23592488Exomic sequencing of four rare central nervous system tumor types.Oncotarget2013
23303741Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2013
23553917Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program.Pediatr Blood Cancer2013
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University of Texas MD Anderson Cancer Center
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Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
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The University of Texas Health Science Center at San Antonio
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University of Chicago
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UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
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Memorial Sloan Kettering Cancer Center
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The Hospital for Sick Children
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Kaiser Permanente San Francisco Medical Center
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