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Author Details

Jennifer L Harris
1997
63
38
PMIDPaper TitleJournal TitlePublished Year
37612291Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5.2023
30559381Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Nature2019
27986745Dual <i>ALK</i> and <i>CDK4/6</i> Inhibition Demonstrates Synergy against Neuroblastoma.Clin Cancer Res2017
28153829Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling.Annals of the Rheumatic Diseases2017
28042617Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct.Cell Stem Cells Regen Med2016
27251290Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.Nature2016
27437076Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.ACS Medicinal Chemistry Letters2016
26825170EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.Cancer Research2016
27117272In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.J Otolaryngol Head Neck Surg2016
26005534(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.ACS Med Chem Lett2015
24675041The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.Cancer Discovery2014
25495526Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.BMC Cancer2014
23392674Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.Journal of Neuroscience2013
23742252Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.J Med Chem2013
24277854Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proc Natl Acad Sci U S A2013
22460905The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Nature2012
21704013Cloning, expression, and enzymatic activity of Acinetobacter baumannii and Klebsiella pneumoniae acetyl-coenzyme A carboxylases.Analytical Biochemistry2011
20015050Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.Biochemical Journal2010
21107320COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Nature2010
20133595Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.Proc Natl Acad Sci U S A2010
20045465Transient expression of an IL-23R extracellular domain Fc fusion protein in CHO vs. HEK cells results in improved plasma exposure.Protein Expression and Purification2010
20632993Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.Biochem J2010
18313933Substrate optimization for monitoring cathepsin C activity in live cells.Bioorganic and Medicinal Chemistry2009
19388054Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.Protein Sci2009
19426707TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7.Biochemical and Biophysical Research Communications2009
18752942Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.Bioorganic and Medicinal Chemistry Letters2008
17382545Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S.Bioorganic and Medicinal Chemistry Letters2007
17710090Small molecules not direct activators of caspases.Nature Chemical Biology2007
17608623Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.Biochem J2007
17804797The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.Proc Natl Acad Sci U S A2007
17976015Defining the extended substrate specificity of kallikrein 1-related peptidases.Biol Chem2007
17196818Bicyclic carbamates as inhibitors of papain-like cathepsin proteases.Bioorganic and Medicinal Chemistry Letters2007
16876402Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.Bioorganic and Medicinal Chemistry Letters2006
17028019Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9.Journal of Molecular Biology2006
16412634Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl.Bioorganic and Medicinal Chemistry Letters2006
17009273Self-assembled small-molecule microarrays for protease screening and profiling.ChemBioChem2006
16798735Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.J Biol Chem2006
16446091Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3.Bioorganic and Medicinal Chemistry Letters2006
16876407Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.Bioorganic and Medicinal Chemistry Letters2006
16307522Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries.Expert Review of Proteomics2005
16038006PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays.Chemistry - A European Journal2005
15932883Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.Journal of Biological Chemistry2005
15878267A strategy to profile prime and non-prime proteolytic substrate specificity.Bioorganic and Medicinal Chemistry Letters2005
16183279Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.Bioorganic and Medicinal Chemistry Letters2005
15157086Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry.Biochemistry2004
15489163Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.2004
15489162PNA-encoded protease substrate microarrays.2004
15474520Biochemical characterization of prostasin, a channel activating protease.Biochemical and Biophysical Research Communications2004
12819769The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.Nat Struct Biol2003
12600991Biochemical analysis of the 20 S proteasome of Trypanosoma brucei.J Biol Chem2003
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