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Author Details

Jonathan R Dry
Present Address: Tempus Labs Inc.
2003
39
20
PMIDPaper TitleJournal TitlePublished Year
36828596Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests: A Blood Profiling Atlas in Cancer (BLOODPAC) Community Study.J Mol Diagn2023
34979999Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets.BMC Cancer2022
35351890Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer.Nat Commun2022
35643464Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort.BMC Cancer2022
35388408Privacy preserving validation for multiomic prediction models.Brief Bioinform2022
36575215The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells.NPJ Precis Oncol2022
34320344A pan-cancer organoid platform for precision medicine.Cell Rep2021
33531613DeePaN: deep patient graph convolutional network integrating clinico-genomic evidence to stratify lung cancers for immunotherapy.NPJ Digit Med2021
33929890BloodPAC Data Commons for Liquid Biopsy Data.JCO Clin Cancer Inform2021
32487991Stratification and prediction of drug synergy based on target functional similarity.NPJ Syst Biol Appl2020
31953314Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response.Clin Cancer Res2020
33205120Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens.Patterns (N Y)2020
31048689MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF<sup>V600E</sup> amplification whereas KRAS<sup>G13D</sup> amplification promotes EMT-chemoresistance.Nat Commun2019
31727888Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.Nat Commun2019
31209238Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.Nat Commun2019
31080552Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in <i>Brca2</i>-mutant mammary tumours.Oncotarget2019
30297535Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.Cancer Res2018
27965317Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia.Cancer Res2017
29296181Correlation between MEK signature and Ras gene alteration in advanced gastric cancer.Oncotarget2017
29245897Comparative analysis of primary <i>versus</i> relapse/refractory DLBCL identifies shifts in mutation spectrum.Oncotarget2017
29092942PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.Cancer Res2017
27733477Clinically Viable Gene Expression Assays with Potential for Predicting Benefit from MEK Inhibitors.Clin Cancer Res2017
26781748Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.BMC Genomics2016
26578606BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data.Nucleic Acids Res2016
27887656Looking beyond the cancer cell for effective drug combinations.Genome Med2016
27573426AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.Mol Cancer Ther2016
27550940Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547.Mol Cancer Ther2016
27060149VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.Nucleic Acids Res2016
27112209Defining actionable mutations for oncology therapeutic development.Nat Rev Cancer2016
25944621A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer.Oncotarget2015
25870145Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models.Cancer Res2015
24170544Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.Clin Cancer Res2014
23840389RNA-Seq Differentiates Tumour and Host mRNA Expression Changes Induced by Treatment of Human Tumour Xenografts with the VEGFR Tyrosine Kinase Inhibitor Cediranib.PLoS One2013
21447798Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.Sci Signal2011
21674991A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P. A. W. Edwards, P. D. Smith, S. J. Cook.Sci Signal2011
21428919Benefits of mTOR kinase targeting in oncology: pre-clinical evidence with AZD8055.Biochem Soc Trans2011
20215513Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244).Cancer Res2010
16478661A bio-basis function neural network for protein peptide cleavage activity characterisation.Neural Netw2006
14642665Searching for discrimination rules in protease proteolytic cleavage activity using genetic programming with a min-max scoring function.Biosystems2003
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Collaborators

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Institute of Computational Biomedicine, Heidelberg University
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Co-authored papers 3
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University of Southern California
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University of Washington
Co-authored papers 2
Bristol-Myers Squibb Co.
Co-authored papers 2
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Co-authored papers 2
Wellcome Sanger Institute
Co-authored papers 2
University of Chicago
Co-authored papers 2
Wellcome Sanger Institute
Co-authored papers 2
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 1
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Clinical Research Division, Fred Hutchinson Cancer Center
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The University of Texas Health Science Center at San Antonio
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Hopp Children's Cancer Center Heidelberg (KiTZ)
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University of Oxford
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Knight Cancer Institute, Oregon Health and Sciences University
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Drew University, National Institutes of Health, Rutgers University New Brunswick, University of North Carolina at Chapel Hill
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