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Author Details

Jeffery M Klco
St. Jude Children's Research Hospital
2000
89
40
PMIDPaper TitleJournal TitlePublished Year
37767572Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical <i>STIL</i>::<i>TAL1</i> fusion events.Haematologica2024
37890156Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.Blood2024
36179268Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.Blood2023
38014207<i>UBTF</i> Tandem Duplications in Pediatric MDS and AML: Implications for Clinical Screening and Diagnosis.medRxiv2023
37790524Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia.Res Sq2023
37601875<i>CBFA2T3::GLIS2</i>-positive acute leukemia with RAM and mixed T/megakaryocytic phenotype.EJHaem2023
37058475Clinical impact of minimal residual disease in blood and bone marrow of children with acute myeloid leukemia.Blood Adv2023
37019972Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.Nat Commun2023
37283355Clinical and genomic characterization of an ATRA-insensitive acute promyelocytic leukemia variant with a FNDC3B::RARB fusion.Genes Chromosomes Cancer2023
37406166Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.Blood Adv2023
37398194Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis.Res Sq2023
36689724SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.Blood Adv2023
36898329From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.Eur J Med Chem2023
34903620Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation.Cancer Discov2022
36074606Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice.J Clin Invest2022
36130297Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.Blood2022
36123353Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia.Nat Commun2022
35914226Engineering naturally occurring CD7- T cells for the immunotherapy of hematological malignancies.Blood2022
35102167CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.Nat Commun2022
35176137Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.Blood Cancer Discov2022
32693409Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia.Blood2021
33823069Activity of venetoclax against relapsed acute undifferentiated leukemia.Cancer2021
33487172SequencErr: measuring and suppressing sequencer errors in next-generation sequencing data.Genome Biol2021
33731850Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.Leukemia2021
33579957The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.Nat Commun2021
35122027Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.Nat Cancer2021
34587228Rational biomarker development for the early and minimally invasive monitoring of AML.Blood Adv2021
34778799Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.Blood Cancer Discov2021
34678152Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.Cancer Cell2021
34301788Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.Cancer Discov2021
34103329Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia.Cancer Discov2021
34233450The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.Haematologica2021
33328584Advances in germline predisposition to acute leukaemias and myeloid neoplasms.Nat Rev Cancer2021
32171069Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.Lancet Oncol2020
31645648A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.Leukemia2020
32809242Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia.Cancer2020
32766874Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.Blood2020
32300185Correction: A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.Leukemia2020
31246522Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial.J Clin Oncol2019
29500178TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.J Exp Med2018
29891567Clonal dynamics of donor-derived myelodysplastic syndrome after unrelated hematopoietic cell transplantation for high-risk pediatric B-lymphoblastic leukemia.Cold Spring Harb Mol Case Stud2018
30046003Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes.JCI Insight2018
30232126Donor-derived MDS/AML in families with germline <i>GATA2</i> mutation.Blood2018
30262806Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome.Nat Commun2018
30380364Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.N Engl J Med2018
27248844Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation.Leuk Lymphoma2017
28487541Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome.Leukemia2017
29146900The genomic landscape of pediatric myelodysplastic syndromes.Nat Commun2017
28872462Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.J Clin Invest2017
28841212Impact of Notch disruption on myeloid development.Blood Cancer J2017
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Collaborators

Washington University School of Medicine
Co-authored papers 21
St. Jude Children's Research Hospital
Co-authored papers 17
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 16
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Co-authored papers 15
The Ohio State University
Co-authored papers 15
Washington University School of Medicine
Co-authored papers 14
St Jude Children's Research Hospital
Co-authored papers 13
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Co-authored papers 12
The Ohio State University
Co-authored papers 12
Changhai Hospital, Second Military Medical University
Co-authored papers 10
St. Jude Children's Research Hospital
Co-authored papers 9
Massachusetts General Hospital
Co-authored papers 9
Centene Center for Health Transformation, Centene Corporation
Co-authored papers 9
St. Jude Children's Research Hospital
Co-authored papers 9
Washington University School of Medicine
Co-authored papers 9
Washington University School of Medicine
Co-authored papers 9
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 9
Washington University School of Medicine in St. Louis
Co-authored papers 8
Washington University School of Medicine.
Co-authored papers 8
St Jude Children's Research Hospital
Co-authored papers 8
Washington University School of Medicine
Co-authored papers 8
The Ohio State University
Co-authored papers 8
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 8
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 8
Washington University School of Medicine in St. Louis
Co-authored papers 7
Washington University School of Medicine.
Co-authored papers 7
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 7
Washington University School of Medicine.
Co-authored papers 6
Clinical Research Division, Fred Hutchinson Cancer Research Center
Co-authored papers 6
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 6