Author details

Full Name

Timothy F Lane

Affiliation

ORCID

Career Start Year

1988

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
29500936	CTLA-4Ig (abatacept) balances bone anabolic effects of T cells and Wnt-10b with antianabolic effects of osteoblastic sclerostin.	Annals of the New York Academy of Sciences	2018
29158473	NOTCH1 is a mechanosensor in adult arteries.	Nature Communications	2017
26400062	Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.	Cancer Res	2015
24586797	PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing.	PLoS One	2014
25369058	IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.	PLoS ONE	2014
24677652	Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling.	Stem Cells	2014
23690447	Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance.	Blood	2013
23954891	Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B.	Blood	2013
24327956	PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response.	Mol Metab	2013
22955916	PTH expands short-term murine hemopoietic stem cells through T cells.	Blood	2012
21324922	Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.	Cancer Res	2011
21266412	Disruption of reelin signaling alters mammary gland morphogenesis.	Development (Cambridge)	2011
20499361	Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells.	Journal of Bone and Mineral Research	2010
20936109	BRCA1 Forms a Functional Complex with Î³-H2AX as a Late Response to Genotoxic Stress.	Journal of Nucleic Acids	2010
20679727	Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.	J Clin Invest	2010
20087412	University of California Research Seminar Network: a prospectus.	PLoS Biology	2010
20152176	Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.	Dev Cell	2010
19455593	A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide.	Journal of Gene Medicine	2009
19297414	Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.	Development	2009
19723499	T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.		2009
19468690	Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors.	J Neurooncol	2009
18219273	Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.	EMBO Journal	2008
19056892	A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.	Genes and Development	2008
17708715	Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation.	J Bone Miner Res	2007
17284610	Wnt signaling interacts with Shh to regulate taste papilla development.	Proceedings of the National Academy of Sciences of the United States of America	2007
17072878	VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium.	Developmental Dynamics	2006
16240122	BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation.	Chromosoma	2005
15930264	The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia.	Cancer Research	2005
15967164	COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice.	Prostaglandins and Other Lipid Mediators	2005
15728361	Regulation of osteoblastogenesis and bone mass by Wnt10b.	Proc Natl Acad Sci U S A	2005
15673614	Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts.	Molecular Biology of the Cell	2005
14688410	Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression.	Proceedings of the National Academy of Sciences of the United States of America	2004
15254397	BRCA1 and transcription.	Cancer Biology and Therapy	2004
15302901	Type I interferon production enhances susceptibility to Listeria monocytogenes infection.	J Exp Med	2004
14699082	Toll-like receptors induce a phagocytic gene program through p38.	Journal of Experimental Medicine	2004
12771726	Immunocytochemical analysis of prostate stem cell antigen as adjunct marker for detection of urothelial transitional cell carcinoma in voided urine specimens.	J Urol	2003
14506230	BRCA1 associates with processive RNA polymerase II.	J Biol Chem	2003
12955082	Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity.	Oncogene	2003
11779215	Identification of a novel endothelial-derived gene EG-1.	Biochem Biophys Res Commun	2002
12163417	Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.	Development (Cambridge)	2002
11278747	Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice.	Journal of Biological Chemistry	2001
11606713	Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor.	Proc Natl Acad Sci U S A	2001
11594763	Human endomucin is an endothelial marker.	Biochem Biophys Res Commun	2001
10878616	Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution.	Developmental Dynamics	2000
10962568	Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice.	Oncogene	2000
10438512	METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.	J Biol Chem	1999
9393971	Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice.	Oncogene	1997
7612967	Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo.	Molecular Biology of the Cell	1995
7539008	SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the Ca(2+)-binding EF-hand.	Journal of Cellular Biochemistry	1995
7590247	Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.	Genes Dev	1995