Author details

Full Name

Brenton R Paolella

Affiliation

ORCID

Career Start Year

2008

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37612728	Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal.	Genome Biol	2023
36127368	Systematic profiling of conditional degron tag technologies for target validation studies.	Nat Commun	2022
35437317	Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.	Nat Cancer	2022
34857952	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	Nat Genet	2021
33753930	A first-generation pediatric cancer dependency map.	Nat Genet	2021
33883167	Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.	Cancer Discov	2021
34260938	Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.	Cell Rep	2021
33326793	Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.	Cell Rep	2020
32433464	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.	Nat Commun	2020
32348107	Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids.	ACS Chemical Biology	2020
32855387	Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.	Nat Commun	2020
31160565	Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.	Nat Commun	2019
31068700	Next-generation characterization of the Cancer Cell Line Encyclopedia.	Nature	2019
31427603	Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.	Nat Commun	2019
28177281	Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.	Elife	2017
26829751	MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.	Nat Genet	2016
26756672	Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.	Stem Cells	2016
27300432	Gliomas "Dope Up" for Growth.	Cancer Cell	2016
25825052	Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.	Neuro Oncol	2015
24425046	Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment.	Cancer Research	2014
24297863	BET bromodomain inhibition of MYC-amplified medulloblastoma.	Clin Cancer Res	2014
23264561	Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice.	DMM Disease Models and Mechanisms	2013
21608079	p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells.	Stem Cells	2011
19109490	Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis.	Journal of Neuroscience	2008