Author details

Full Name

David A Brenner

Affiliation

ORCID

Career Start Year

1975

Papers

458

H Index

129

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37743012	The Origin and Fate of Liver Myofibroblasts.	Cell Mol Gastroenterol Hepatol	2024
37247063	Human Hepatic Stellate Cells: Isolation and Characterization.		2023
37405925	Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers.		2023
36893735	Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease.	Cell Host Microbe	2023
36882540	Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.	Nature	2023
36712797	Introducing <i>PNAS Nexus</i>.	PNAS Nexus	2022
36358290	The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury.	Biology	2022
35700738	MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH.	Cell Metab	2022
36001995	Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD.	Semin Liver Dis	2022
36067186	Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC.	PLoS ONE	2022
36198801	Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.	Nature	2022
35921818	Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis.		2022
34879108	PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells.	PLoS ONE	2021
34242094	Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice.	American Journal of Physiology - Heart and Circulatory Physiology	2021
33540107	Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury.	International Journal of Biochemistry and Cell Biology	2021
34119473	Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.	Am J Pathol	2021
34062281	Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet.	Cell Mol Gastroenterol Hepatol	2021
33631374	Intestinal Î±1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.	Cell Mol Gastroenterol Hepatol	2021
34253615	Immunotherapy-based targeting of MSLN<sup>+</sup> activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.	Proc Natl Acad Sci U S A	2021
33550587	Heterogeneity of HSCs in a Mouse Model of NASH.	Hepatology	2021
33128017	Molecular and cellular mechanisms of liver fibrosis and its regression.	Nature Reviews Gastroenterology and Hepatology	2021
34966784	The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis.	Frontiers in Molecular Biosciences	2021
34887405	CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.	Nat Commun	2021
32629454	Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of AlstrÃ¶m Syndrome.	Nephron	2020
32258954	Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles.	Hepatol Commun	2020
31899206	IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.	J Hepatol	2020
32051339	Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.	JCI Insight	2020
32160239	Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.	PLoS ONE	2020
31761566	Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.	Cell Metab	2020
32390870	Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder.	Front Physiol	2020
31982409	Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.	Gastroenterology	2020
31924111	Mechanisms of liver fibrosis and its role in liver cancer.	Experimental Biology and Medicine	2020
32492075	Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.	PLoS ONE	2020
33210080	Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice.		2020
32654263	Intestinal Virome in Patients With Alcoholic Hepatitis.	Hepatology	2020
33147487	A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.	Cell Metab	2020
32534258	Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2Î±-dependent mechanism.	Molecular Metabolism	2020
30959975	The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma.	International Journal of Molecular Sciences	2019
31693880	The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.		2019
30506692	Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD.	Aliment Pharmacol Ther	2019
30445007	NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.	Gastroenterology	2019
30240894	Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians.	Clin Gastroenterol Hepatol	2019
30567742	Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease.	Gut	2019
31289229	YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.	Proc Natl Acad Sci U S A	2019
30926798	A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease.	Nat Commun	2019
30766956	Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis.	Hepatology Communications	2019
31484056	Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.	Cell Metab	2019
30859582	Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography.	Hepatology	2019
31071368	Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.	J Hepatol	2019
29785003	Publisher Correction: The gut-liver axis and the intersection with the microbiome.	Nat Rev Gastroenterol Hepatol	2018