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Author Details

Peter J Houghton
The University of Texas Health Science Center at San Antonio
1971
651
94
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37812652Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma.Clin Cancer Res2024
36162055Sensitization to Ionizing Radiation by MEK Inhibition Is Dependent on SNAI2 in Fusion-Negative Rhabdomyosarcoma.Mol Cancer Ther2023
37915590Comprehensive characterization of patient-derived xenograft models of pediatric leukemia.iScience2023
37990009Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer.Nat Commun2023
37243594EWSR1 maintains centromere identity.Cell Rep2023
37359725DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer.Bioinform Adv2023
36696581Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma.Mol Cancer Ther2023
36773293Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma.Cell Rep2023
36603130Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time.Cancer Res2023
36250964Evaluation of the pan-class I phosphoinositide 3-kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium in vivo models of osteosarcoma.Pediatr Blood Cancer2023
34737198Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in <i>H/NRAS<sup>Q61X</sup></i> Mutant Rhabdomyosarcoma.Mol Cancer Ther2022
35797217Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models.Clin Cancer Res2022
35450020Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma.Cancer Drug Resist2022
35657346Trastuzumab Deruxtecan, Antibody-Drug Conjugate Targeting HER2, Is Effective in Pediatric Malignancies: A Report by the Pediatric Preclinical Testing Consortium.Mol Cancer Ther2022
36433963Genomic disparities between cancers in adolescent and young adults and in older adults.Nat Commun2022
35129140Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models.J Pediatr Hematol Oncol2022
35312779Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma.Mol Cancer Ther2022
34997546Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells.Cell Oncol (Dordr)2022
35303054M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.Cancer Res2022
35017650Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma.NPJ Precis Oncol2022
32810235PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models.Nucleic Acids Res2021
33619171The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.Clin Cancer Res2021
33564073MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.Oncogene2021
33691584Regulation of DNA duplication by the mTOR signaling pathway.Cell Cycle2021
33916592Developing New Agents for Treatment of Childhood Cancer: Challenges and Opportunities for Preclinical Testing.J Clin Med2021
33915882Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children's Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force.J Clin Med2021
35098099PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma.iScience2021
34944795Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma.Cancers (Basel)2021
34462275SNAI2-Mediated Repression of <i>BIM</i> Protects Rhabdomyosarcoma from Ionizing Radiation.Cancer Res2021
34453478In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC).Pediatr Blood Cancer2021
34417181Predicting and characterizing a cancer dependency map of tumors with deep learning.Sci Adv2021
34345820The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma.Neurooncol Adv2021
34205996Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells.Cells2021
34233189NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth.Cell Rep2021
34137164Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force.Pediatr Blood Cancer2021
34108262International Consensus on Minimum Preclinical Testing Requirements for the Development of Innovative Therapies For Children and Adolescents with Cancer.Mol Cancer Ther2021
33089597In vivo evaluation of the EZH2 inhibitor (EPZ011989) alone or in combination with standard of care cytotoxic agents against pediatric malignant rhabdoid tumor preclinical models-A report from the Pediatric Preclinical Testing Consortium.Pediatr Blood Cancer2021
33420019Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.Nat Commun2021
33323380A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.Cancer Res2021
32827353Radiation therapy and molecular-targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges.Pediatr Blood Cancer2021
31621900GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma.Int J Cancer2020
32082485Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease.Oncotarget2020
31927611Prospective use of the single-mouse experimental design for the evaluation of PLX038A.Cancer Chemother Pharmacol2020
31975571Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report.Pediatr Blood Cancer2020
33147457GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth.Cell Rep2020
32706456Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium.Pediatr Blood Cancer2020
32676162Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway.Oncotarget2020
32184294Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts.Clin Cancer Res2020
32333633Evaluation of VTP-50469, a menin-MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium.Pediatr Blood Cancer2020
32207565Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium.Pediatr Blood Cancer2020
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Collaborators

National Cancer Institute
Co-authored papers 110
The University of Texas Health Science Center at San Antonio
Co-authored papers 84
University of Texas MD Anderson Cancer Center
Co-authored papers 82
Co-authored papers 76
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 74
Co-authored papers 73
Children's Hospital of Philadelphia
Co-authored papers 71
Cancer Center, Texas Tech University Health Sciences Center
Co-authored papers 70
St. Jude Children's Research Hospital.
Co-authored papers 62
Co-authored papers 19
Keck School of Medicine, University of Southern California
Co-authored papers 18
The University of Texas Health Science Center at San Antonio
Co-authored papers 14
St. Jude Children's Research Hospital
Co-authored papers 12
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 12
St Jude Children's Research Hospital
Co-authored papers 12
Greehey Children's Cancer Research Institute
Co-authored papers 10
Co-authored papers 10
Greehey Children's Cancer Research Institute
Co-authored papers 9
Center for Cancer Research, National Cancer Institute
Co-authored papers 9
Co-authored papers 9
University of Texas MD Anderson Cancer Center
Co-authored papers 8
St. Jude Children's Research Hospital
Co-authored papers 7
St. Jude Children's Research Hospital
Co-authored papers 6
Osteosarcoma Institute
Co-authored papers 6
The University of Texas MD Anderson Cancer Center
Co-authored papers 5
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 5
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 4
St Jude Children's Research Hospital
Co-authored papers 4
Georgetown University Medical Center, Georgetown University
Co-authored papers 4
University of Texas Health Science Center
Co-authored papers 4