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Author Details

Ian D Clarke
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
1997
28
25
PMIDPaper TitleJournal TitlePublished Year
30842215Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.Genes Dev2019
28712938ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell Stem Cell2017
28886368ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.Cell Stem Cell2017
27300435Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.Cancer Cell2016
25561528Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.Proc Natl Acad Sci U S A2015
26626085MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.Cancer Cell2015
24553142Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.Nature2014
25100205ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Cancer Discov2014
24954133Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.Cancer Cell2014
23108137A tumorigenic MLL-homeobox network in human glioblastoma stem cells.Cancer Res2013
21208905Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition.Clin Cancer Res2011
21765395Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.EMBO J2011
21464220A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.J Exp Med2011
20357002Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.Mol Biol Cell2010
19487286Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.Cancer Res2009
19962671Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.Cancer Cell2009
19710912MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy.PLoS One2009
19497285Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.Cell Stem Cell2009
17417631Chemical genetics reveals a complex functional ground state of neural stem cells.Nat Chem Biol2007
16982749IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.Cancer Res2006
15378086Cancer stem cells in nervous system tumors.Oncogene2004
15549107Identification of human brain tumour initiating cells.Nature2004
12569364A human brain tumor-derived PDGFR-alpha deletion mutant is transforming.Oncogene2003
14522905Identification of a cancer stem cell in human brain tumors.Cancer Res2003
10762210Murine xenogeneic immune responses to the human testis: a presumed immune-privileged tissue.Transplantation2000
10385090T cells are necessary and critical for xenograft rejection in new concordant cardiac xenotransplant model.Transplantation1999
9041398Comparison of the western blot assay with the neutralizing-antibody and enzyme-linked immunosorbent assays for measuring antibody to verocytotoxin 1.J Clin Microbiol1997
9199412Localization of intravenously administered verocytotoxins (Shiga-like toxins) 1 and 2 in rabbits immunized with homologous and heterologous toxoids and toxin subunits.Infect Immun1997
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Collaborators

Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 23
Cynthia Hawkins
The Hospital for Sick Children
Co-authored papers 6
Gary D Bader
University of Toronto
Co-authored papers 6
Michael D Cusimano
St. Michael's Hospital, University of Toronto
Co-authored papers 6
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 5
Marc Remke
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 4
Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 4
Jeremy A Squire
University of Sao Paulo
Co-authored papers 4
Marco Gallo
Co-authored papers 4
James T Rutka
Hospital for Sick Children
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Sheila K Singh
McMaster University
Co-authored papers 3
David Malkin
Hospital for Sick Children
Co-authored papers 3
Jane Bayani
Ontario Institute for Cancer Research
Co-authored papers 3
Stephen W Scherer
The Hospital for Sick Children
Co-authored papers 3
Sameer Agnihotri
Co-authored papers 3
Stefan M Pfister
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 3
Kinjal Desai
New York Presbyterian Morgan Stanley Children's Hospital
Co-authored papers 3
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 3
Andrey Korshunov
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 2
Eric Bouffet
The Hospital for Sick Children
Co-authored papers 2
Gurnit Atwal
Ontario Institute for Cancer Research Toronto
Co-authored papers 2
Marco A Marra
University of British Columbia
Co-authored papers 2
Kenneth Aldape
National Cancer Institute
Co-authored papers 2
Paul Guilhamon
The Hospital for Sick Children
Co-authored papers 2
Timothy E Van Meter
Virginia Commonwealthy University
Co-authored papers 2
Annie Huang
Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children
Co-authored papers 2
Marcel Kool
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Uri Tabori
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