Author details

Full Name

Costas A Lyssiotis

Affiliation

ORCID

Career Start Year

2004

Papers

167

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36993718	Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer.	bioRxiv	2024
36843552	A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.		2023
37745344	Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation.		2023
37584601	Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.	Cancer Discov	2023
37647805	Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma.	Neoplasia	2023
37579983	Iron promotes glycolysis to drive colon tumorigenesis.		2023
37904965	H S preconditioning induces long-lived perturbations in O metabolism.		2023
37902550	GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.		2023
38085578	Itaconate suppresses atherosclerosis by activating a Nrf2-dependent anti-inflammatory response in macrophages in mice.		2023
37635751	Spotlight on GOT2 in Cancer Metabolism.		2023
37567975	Uridine: as sweet as sugar for some cells?		2023
37790517	Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma.		2023
37961582	Rewiring of cortical glucose metabolism fuels human brain cancer growth.		2023
37857710	Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation.		2023
37090571	GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.		2023
37279645	M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.	Neuro Oncol	2023
37267902	An unexpected pathway to polyamines in pancreatic cancer.		2023
37198494	Uridine-derived ribose fuels glucose-restricted pancreatic cancer.		2023
36880731	Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.		2023
36703617	Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.		2023
37069167	Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis.	Nat Commun	2023
37254839	Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.		2023
37059070	Pancreatic cancer: Advances and challenges.	Cell	2023
36739364	Nutrient transporters: connecting cancer metabolism to therapeutic opportunities.		2023
36993187	Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.		2023
36735777	Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.		2023
37169842	GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.	Nat Cancer	2023
37037306	PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.	J Biol Chem	2023
37503050	De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression.		2023
34808207	A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent HS oxidation.	Journal of Biological Chemistry	2022
35590211	Ketotherapy: Cutting carbs to treat cancer.	Med	2022
35700791	ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages.		2022
36288696	NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.	Cell Reports	2022
35819845	Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP-Dependent Malic Enzyme 1.	Biochemistry	2022
35815941	Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.	eLife	2022
35944066	Functional and biological heterogeneity of KRAS<sup>Q61</sup> mutations.	Sci Signal	2022
36276057	Amino acid metabolism in primary bone sarcomas.	Front Oncol	2022
35739422	Author Correction: Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.	Nat Cancer	2022
35422502	Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.	Nat Cancer	2022
35681100	Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.	Nature Cancer	2022
35484254	Targeting allosteric regulation of cancer metabolism.	Nature Chemical Biology	2022
36329027	GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.	Blood Cancer Journal	2022
35732800	Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer.	Oncogene	2022
35404121	Human Norovirus Triggers Primary B Cell Immune Activation .	mBio	2022
36411320	Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.	Nat Cancer	2022
36399539	OXPHOS promotes apoptotic resistance and cellular persistence in T17 cells in the periphery and tumor microenvironment.	Science immunology	2022
34951957	Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance.	Cancer Cell	2022
35140120	In an Era of ctDNA, Is Metabolomics the New Kid on the Block?	Clinical Cancer Research	2022
35156921	Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway.	eLife	2022
35065965	Metabolic regulation of ferroptosis in the tumor microenvironment.	Journal of Biological Chemistry	2022