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Author Details

Ashok R Venkitaraman
University of Cambridge, Hutchison Research Centre
1982
174
61
PMIDPaper TitleJournal TitlePublished Year
36824830Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.bioRxiv2023
37626143A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells.Nat Commun2023
37311455Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.Cell Metab2023
36977662Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.Nat Commun2023
35322373Multiple cycles of granulocyte colony-stimulating factor in decompensated cirrhosis: a double-blind RCT.Hepatol Int2022
36426237A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action.RSC Med Chem2022
35235448Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.Proc Natl Acad Sci U S A2022
34111400Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library.Cell Chem Biol2021
35419470A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops).Mol Cell Oncol2021
34348152BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.Cell Rep2021
33953383Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP.Nat Struct Mol Biol2021
33978741Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance.Nucleic Acids Res2021
31570788ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.Oncogene2020
32075732Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage.Cell Rep2020
32652013A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation.Nucleic Acids Res2020
32641771Author Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP.Nat Struct Mol Biol2020
32350249Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.Nat Commun2020
31060813Enhancing Biochemical Resolution by Hyperdimensional Imaging Microscopy.Biophys J2019
31956833Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.ACS Omega2019
31685831A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.Sci Rep2019
31570875A systems view of spliceosomal assembly and branchpoints with iCLIP.Nat Struct Mol Biol2019
31422954Fast single-cell biochemistry: theory, open source microscopy and applications.Methods Appl Fluoresc2019
31337537How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?DNA Repair (Amst)2019
31334915Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain.ChemMedChem2019
29309696Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.Nucleic Acids Res2018
30269933Science in Focus: Genomic Instability and its Implications for Clinical Cancer Care.Clin Oncol (R Coll Radiol)2018
30560944BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.Nat Commun2018
29386125BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.Cell Rep2018
29606576Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.Cell Chem Biol2018
28787041Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.Chem Commun (Camb)2017
28807782Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.Cell Chem Biol2017
28768205Impact of Alternative Splicing on the Human Proteome.Cell Rep2017
28575672A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.Cell2017
26895423RNA Processing and Genome Stability: Cause and Consequence.Mol Cell2016
28451126Specific inhibition of CK2α from an anchor outside the active site.Chem Sci2016
27725183Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.J Mol Biol2016
27596592High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Nucleic Acids Res2016
27412232Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.Sci Rep2016
27339427Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.Sci Rep2016
25406193Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.Cancer Res2015
28966765Synthesis of a novel polycyclic ring scaffold with antimitotic properties <i>via</i> a selective domino Heck-Suzuki reaction.Chem Sci2015
26368450Fast and simple spectral FLIM for biochemical and medical imaging.Opt Express2015
26392272Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.Genome Biol2015
26768531Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.Angew Chem Int Ed Engl2015
26091166Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Chem Biol2015
26111201Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.Cell Cycle2015
25470112Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases.ChemMedChem2015
24268522Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.Mol Oncol2014
25486198p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.Cell Cycle2014
25486196A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.Cell Cycle2014
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Collaborators

Tom L Blundell
Heartand Lung Research Institute, University of Cambridge
Co-authored papers 9
Mahmud K K Shivji
Medical Research Council Cancer Unit, University of Cambridge
Co-authored papers 8
Yansheng Liu
Yale University School of Medicine
Co-authored papers 4
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 3
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Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 3
Mathew J Garnett
Wellcome Sanger Institute
Co-authored papers 2
Shaoxia Chen
Medical Research Council Laboratory of Molecular Biology
Co-authored papers 2
Mar Gonz??lez-Porta
Illumina Cambridge Ltd
Co-authored papers 2
Mona Shehata
University of Cambridge
Co-authored papers 2
Michael J Owen
Co-authored papers 2
Madan Mohan Babu
St. Jude Children's Research Hospital
Co-authored papers 2
Judith M Short
Medical Research Council Laboratory of Molecular Biology
Co-authored papers 2
Cyril B Gilks
University of British Columbia
Co-authored papers 1
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Stanford University
Co-authored papers 1
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Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 1
Mallur S Madhusudhan
Indian Institute of Science Education and Research Pune
Co-authored papers 1
Carol V Robinson
University of Oxford
Co-authored papers 1
Simon Tavar??
Irving Institute for Cancer Dynamics, Columbia University
Co-authored papers 1
John A Tainer
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Chris P Ponting
The University of Edinburgh
Co-authored papers 1
Sheena D'Arcy
The University of Texas at Dallas
Co-authored papers 1
Sunil R Lakhani
University of Queensland
Co-authored papers 1
Andrew L Trinh
Co-authored papers 1
David E Neal
University of Oxford, John Radcliffe Hospital
Co-authored papers 1
Peter Ellis
Co-authored papers 1
Vincent Peter Collins
Mount Sinai Hospital
Co-authored papers 1
Alexander Marson
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 1
David G Huntsman
University of British Columbia
Co-authored papers 1
Christina Curtis
Stanford University School of Medicine
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Release 1.2