Author details

Full Name

Fred E Cohen

Affiliation

University of California san francisco

ORCID

Career Start Year

1979

Papers

215

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
20107515	Protease-sensitive synthetic prions.	PLoS Pathog	2010
19805070	Natural and synthetic prion structure from X-ray fiber diffraction.	Proc Natl Acad Sci U S A	2009
20006956	Molecular modeling of the misfolded insulin subunit and amyloid fibril.	Biophys J	2009
19604481	Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein.	Structure	2009
18398908	Analysis of the sequence and structural features of the left-handed beta-helical fold.	Proteins	2008
18559949	Genes contributing to prion pathogenesis.	J Gen Virol	2008
17201410	Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.	J Med Chem	2007
17935686	Electron crystallography of the scrapie prion protein complexed with heavy metals.	Arch Biochem Biophys	2007
17989223	Cell division modulates prion accumulation in cultured cells.	Proc Natl Acad Sci U S A	2007
17274683	Automatic extraction of protein point mutations using a graph bigram association.	PLoS Comput Biol	2007
17374787	Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.	J Gen Virol	2007
17371810	Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.	Antimicrob Agents Chemother	2007
16432139	Developing therapeutics for the diseases of protein misfolding.	Neurology	2006
17142317	Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.	Proc Natl Acad Sci U S A	2006
16962610	Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.	J Mol Biol	2006
16860557	Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.	Bioorg Med Chem Lett	2006
16882315	Searching for new antimalarial therapeutics amongst known drugs.	Chem Biol Drug Des	2006
15671162	Strain-specified characteristics of mouse synthetic prions.	Proc Natl Acad Sci U S A	2005
16344478	Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.	Proc Natl Acad Sci U S A	2005
15146195	Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.	Nat Biotechnol	2004
15286374	Synthetic mammalian prions.	Science	2004
14747574	Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.	J Virol	2004
14990452	Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors.	Bioinformatics	2004
15124628	Prions: so many fibers, so little infectivity.	Trends Biochem Sci	2004
15155909	Evidence for assembly of prions with left-handed beta-helices into trimers.	Proc Natl Acad Sci U S A	2004
12520006	GPCRDB information system for G protein-coupled receptors.	Nucleic Acids Res	2003
12972255	New local potential useful for genome annotation and 3D modeling.	J Mol Biol	2003
14685252	Therapeutic approaches to protein-misfolding diseases.	Nature	2003
12620119	Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray.	Genome Biol	2003
12569425	Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family.	J Mol Evol	2003
12626750	Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.	Proc Natl Acad Sci U S A	2003
11891310	Structural studies of the scrapie prion protein by electron crystallography.	Proc Natl Acad Sci U S A	2002
12271119	Dominant-negative inhibition of prion replication in transgenic mice.	Proc Natl Acad Sci U S A	2002
12224510	Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors.	Curr Top Microbiol Immunol	2002
12537566	JEvTrace: refinement and variations of the evolutionary trace in JAVA.	Genome Biol	2002
12421567	Co-evolutionary analysis reveals insights into protein-protein interactions.	J Mol Biol	2002
12031671	Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly.	Chem Biol	2002
12031337	CoMFA and HQSAR of acylhydrazide cruzain inhibitors.	Bioorg Med Chem Lett	2002
12061873	Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.	J Med Chem	2002
11912192	Pathway complexity of prion protein assembly into amyloid.	J Biol Chem	2002
11784134	Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.	J Med Chem	2002
11866533	Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation.	J Mol Biol	2002
11152514	Identification of two prion protein regions that modify scrapie incubation time.	J Virol	2001
11274476	Strain-specified relative conformational stability of the scrapie prion protein.	Protein Sci	2001
11274473	Conformational propagation with prion-like characteristics in a simple model of protein folding.	Protein Sci	2001
11306559	Folding of prion protein to its native alpha-helical conformation is under kinetic control.	J Biol Chem	2001
11226243	Two different neurodegenerative diseases caused by proteins with similar structures.	Proc Natl Acad Sci U S A	2001
11259607	A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice.	Mol Cell Biol	2001
11258885	Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.	Biochemistry	2001
11254392	Pairwise sequence alignment below the twilight zone.	J Mol Biol	2001

1 - 50 of 215

Nikolay V Dokholyan

Pennsylvania State University College of Medicine

Career Start Year 1998

Number of shared co-authors 5

J Michael Sauder

Eli Lilly and Co.

Career Start Year 1996

Number of shared co-authors 1

Mallur S Madhusudhan

Indian Institute of Science Education and Research Pune

Career Start Year 1996

Number of shared co-authors 1

Michele Vendruscolo

University of Cambridge

Career Start Year 1996

Number of shared co-authors 3

James C Whisstock

Monash University

Career Start Year 1994

Number of shared co-authors 3

Robert B Russell

Heidelberg University

Career Start Year 1991

Number of shared co-authors 1

Paul A Bates

The Francis Crick Institute

Career Start Year 1989

Number of shared co-authors 1

David Baker

University of Washington

Career Start Year 1988

Number of shared co-authors 6

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 1

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 1

Mark S Johnson

Abo Akademi University

Career Start Year 1985

Number of shared co-authors 0

Stanley R Krystek

Bristol-Myers Squibb Pharmaceutical Research Institute

Career Start Year 1985

Number of shared co-authors 2

Andrej Sali (CM4AI)

University of California San Francisco

Career Start Year 1985

Number of shared co-authors 16

Alexei A Adzhubei

4Washington University School of Medicine and Health Sciences

Career Start Year 1982

Number of shared co-authors 2

William F DeGrado

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1982

Number of shared co-authors 6

Randy J Read

Cambridge Institute for Medical Research, University of Cambridge

Career Start Year 1982

Number of shared co-authors 0

Thomas C Terwilliger

Los Alamos National Laboratory

Career Start Year 1980

Number of shared co-authors 0

Ruth Nussinov

Sackler School of Medicine, Tel Aviv University

Career Start Year 1980

Number of shared co-authors 0

David S Moss

Institute of Structural and Molecular Biology, University of London

Career Start Year 1976

Number of shared co-authors 0

Shoshana J Wodak

VIB-VUB Center for Structural Biology

Career Start Year 1975

Number of shared co-authors 3

Charles L Brooks

University of Michigan ann arbor

Career Start Year 1974

Number of shared co-authors 2

Christopher M Dobson

University of Cambridge

Career Start Year 1973

Number of shared co-authors 3

Joel L Sussman

Weizmann Institute of Science

Career Start Year 1971

Number of shared co-authors 1

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 1

John Moult

Institute for Bioscience and Biotechnology Research

Career Start Year 1970

Number of shared co-authors 5

Michael Levitt

Stanford University

Career Start Year 1969

Number of shared co-authors 3

Andras Fiser

Albert Einstein College of Medicine

Career Start Year 1968

Number of shared co-authors 2

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 2

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 2

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 2

row(s) 1 - 30 of 30

Stanley B Prusiner

Weill Institute for Neurosciences, University of California San Francisco

Co-authored papers 90

Stephen J DeArmond

Co-authored papers 21

Robert J Fletterick

University of California San Francisco

Co-authored papers 13

Barnaby C H May

Research and Clinical Development

Co-authored papers 12

Scott Presnell

Benaroya Research Institute

Co-authored papers 10

Michael J E Sternberg

Imperial College London

Co-authored papers 10

James H McKerrow

Sandler Center for Drug Discovery, University of California San Francisco

Co-authored papers 9

Dietlind L Gerloff

Foundation for Applied Molecular Evolution (FfAME)

Co-authored papers 6

Marcin P Joachimiak

E O Lawrence Berkeley National Laboratory, UCSF Medical Center, University of California, Berkeley, University of Chicago

Co-authored papers 6

Roland L Dunbrack

Fox Chase Cancer Center

Co-authored papers 6

Dirk Walther

Max Planck Institute of Molecular Plant Physiology

Co-authored papers 4

Chern-Sing Goh

Yale University

Co-authored papers 4

Steven A Benner

Foundation for Applied Molecular Evolution

Co-authored papers 4

Olivier Lichtarge

Baylor College of Medicine

Co-authored papers 4

George A Carlson

Co-authored papers 3

Conor R Caffrey

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Co-authored papers 3

Philip J Rosenthal

University of California at San Francisco

Co-authored papers 3

A A Bogan

University of California san francisco

Co-authored papers 3

Joseph L DeRisi

University of California San Francisco

Co-authored papers 2

Carrie L Byington

UCSF School of Medicine, University of California Health

Co-authored papers 2

Henry R Bourne

Co-authored papers 2

Robert Abarbanel

Co-authored papers 2

Robert W Mahley

Gladstone Institute of Neurological Disease

Co-authored papers 2

John-Marc Chandonia

Lawrence Berkeley National Laboratory

Co-authored papers 2

Gina Cannarozzi

University of Bern

Co-authored papers 2

Jennifer L Weisman

University of California san francisco

Co-authored papers 2

Barry Honig

Columbia University Irving Medical Center

Co-authored papers 2

Peter A Kollman

Co-authored papers 2

Kurt Giles

UCSF Weill Institute for Neurosciences, University of California san francisco

Co-authored papers 2

Fabien Campagne

Weill Cornell Medical College

Co-authored papers 1

1 - 30

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