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Author Details
Full Name
Lorraine Pillus
Affiliation
University of California San Diego
ORCID
Career Start Year
1980
Papers
86
H Index
37
Expertise
CM4AI Collaborator
Trey Ideker (CM4AI)
PMID
Paper Title
Journal Title
Published Year
36772957
Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls.
G3 (Bethesda)
2023
37104589
Engineering longevity-design of a synthetic gene oscillator to slow cellular aging.
Science
2023
36194205
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis.
Elife
2022
32798737
Cell cycle roles for GCN5 revealed through genetic suppression.
Biochim Biophys Acta Gene Regul Mech
2021
32675375
A programmable fate decision landscape underlies single-cell aging in yeast.
Science
2020
33880425
Advances in quantitative biology methods for studying replicative aging in <i>Saccharomyces cerevisiae</i>.
Transl Med Aging
2020
30852250
Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics.
Cell Syst
2019
28884217
Critical genomic regulation mediated by Enhancer of Polycomb.
Curr Genet
2018
29995571
Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint.
Mol Biol Cell
2018
28662109
Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.
PLoS One
2017
28108589
Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.
Genetics
2017
29073021
Multigenerational silencing dynamics control cell aging.
Proc Natl Acad Sci U S A
2017
28568901
The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.
Aging Cell
2017
26936955
Functions for diverse metabolic activities in heterochromatin.
Proc Natl Acad Sci U S A
2016
27317677
Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.
Genetics
2016
25628362
A moonlighting metabolic protein influences repair at DNA double-stranded breaks.
Nucleic Acids Res
2015
26303527
The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response.
Mol Cell Biol
2015
24532730
Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae.
Genetics
2014
25252977
Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation.
Nature
2014
25043177
The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.
Cell Rep
2014
24831819
Bypassing the requirement for an essential MYST acetyltransferase.
Genetics
2014
23291096
Decoupling epigenetic and genetic effects through systematic analysis of gene position.
Cell Rep
2013
23870137
Balancing chromatin remodeling and histone modifications in transcription.
Trends Genet
2013
23175389
STUbLs in chromatin and genome stability.
Biopolymers
2013
23050233
Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions.
G3 (Bethesda)
2012
23055944
Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.
PLoS Genet
2012
20089861
Structural basis for L-lysine feedback inhibition of homocitrate synthase.
J Biol Chem
2010
20810648
Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.
Genes Dev
2010
19270744
Identifying critical non-catalytic residues that modulate protein kinase A activity.
PLoS One
2009
19596907
Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae.
Genetics
2009
19776021
Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J Biol Chem
2009
19737915
The SAGA subunit Ada2 functions in transcriptional silencing.
Mol Cell Biol
2009
19372386
Dynamic reprogramming of transcription factors to and from the subtelomere.
Genome Res
2009
19541632
The glucanosyltransferase Gas1 functions in transcriptional silencing.
Proc Natl Acad Sci U S A
2009
18086879
Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.
Mol Cell Biol
2008
18511253
MYSTs mark chromatin for chromosomal functions.
Curr Opin Cell Biol
2008
17971450
Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.
J Biol Chem
2008
17694079
MYST opportunities for growth control: yeast genes illuminate human cancer gene functions.
Oncogene
2007
18022353
New nomenclature for chromatin-modifying enzymes.
Cell
2007
16436512
Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.
Mol Biol Cell
2006
17110954
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.
EMBO Rep
2006
16951088
Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated.
Genetics
2006
15719021
Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms.
EMBO J
2005
16278456
Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae.
Eukaryot Cell
2005
16079916
Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.
EMBO J
2005
15545655
Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+.
Genetics
2005
14979016
Functional analyses of chromatin modifications in yeast.
Methods Enzymol
2004
16117657
SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae.
Cold Spring Harb Symp Quant Biol
2004
15199156
Molecular requirements for gene expression mediated by targeted histone acetyltransferases.
Mol Cell Biol
2004
12571358
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.
Proc Natl Acad Sci U S A
2003
1 - 50 of 86
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