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Author Details

Lorraine Pillus
University of California San Diego
1980
86
37
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36772957Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls.G3 (Bethesda)2023
37104589Engineering longevity-design of a synthetic gene oscillator to slow cellular aging.Science2023
36194205Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis.Elife2022
32798737Cell cycle roles for GCN5 revealed through genetic suppression.Biochim Biophys Acta Gene Regul Mech2021
32675375A programmable fate decision landscape underlies single-cell aging in yeast.Science2020
33880425Advances in quantitative biology methods for studying replicative aging in <i>Saccharomyces cerevisiae</i>.Transl Med Aging2020
30852250Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics.Cell Syst2019
28884217Critical genomic regulation mediated by Enhancer of Polycomb.Curr Genet2018
29995571Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint.Mol Biol Cell2018
28662109Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.PLoS One2017
28108589Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.Genetics2017
29073021Multigenerational silencing dynamics control cell aging.Proc Natl Acad Sci U S A2017
28568901The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.Aging Cell2017
26936955Functions for diverse metabolic activities in heterochromatin.Proc Natl Acad Sci U S A2016
27317677Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.Genetics2016
25628362A moonlighting metabolic protein influences repair at DNA double-stranded breaks.Nucleic Acids Res2015
26303527The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response.Mol Cell Biol2015
24532730Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae.Genetics2014
25252977Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation.Nature2014
25043177The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.Cell Rep2014
24831819Bypassing the requirement for an essential MYST acetyltransferase.Genetics2014
23291096Decoupling epigenetic and genetic effects through systematic analysis of gene position.Cell Rep2013
23870137Balancing chromatin remodeling and histone modifications in transcription.Trends Genet2013
23175389STUbLs in chromatin and genome stability.Biopolymers2013
23050233Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions.G3 (Bethesda)2012
23055944Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.PLoS Genet2012
20089861Structural basis for L-lysine feedback inhibition of homocitrate synthase.J Biol Chem2010
20810648Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.Genes Dev2010
19270744Identifying critical non-catalytic residues that modulate protein kinase A activity.PLoS One2009
19596907Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae.Genetics2009
19776021Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.J Biol Chem2009
19737915The SAGA subunit Ada2 functions in transcriptional silencing.Mol Cell Biol2009
19372386Dynamic reprogramming of transcription factors to and from the subtelomere.Genome Res2009
19541632The glucanosyltransferase Gas1 functions in transcriptional silencing.Proc Natl Acad Sci U S A2009
18086879Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.Mol Cell Biol2008
18511253MYSTs mark chromatin for chromosomal functions.Curr Opin Cell Biol2008
17971450Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.J Biol Chem2008
17694079MYST opportunities for growth control: yeast genes illuminate human cancer gene functions.Oncogene2007
18022353New nomenclature for chromatin-modifying enzymes.Cell2007
16436512Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.Mol Biol Cell2006
17110954Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.EMBO Rep2006
16951088Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated.Genetics2006
15719021Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms.EMBO J2005
16278456Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae.Eukaryot Cell2005
16079916Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.EMBO J2005
15545655Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+.Genetics2005
14979016Functional analyses of chromatin modifications in yeast.Methods Enzymol2004
16117657SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae.Cold Spring Harb Symp Quant Biol2004
15199156Molecular requirements for gene expression mediated by targeted histone acetyltransferases.Mol Cell Biol2004
12571358Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.Proc Natl Acad Sci U S A2003
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Collaborators

Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 5
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 4
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L'Institut Suisse de Recherche Experimentale sur le Cancer (ISREC) Foundation
Co-authored papers 3
The Wistar Institute
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Northwestern University Feinberg School of Medicine
Co-authored papers 2
Centre Hospitalier Universitaire (CHU) de Quebec-Universite Laval Research Center
Co-authored papers 2
University of California berkeley
Co-authored papers 2
HHMI/NYU Langone School of Medicine
Co-authored papers 1
Salk Institute
Co-authored papers 1
University of California
Co-authored papers 1
University of California los angeles
Co-authored papers 1
Laval University Cancer Research Center
Co-authored papers 1
The Rockefeller University
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Salk Institute for Biological Studies
Co-authored papers 1
University of California
Co-authored papers 1
Calico Life Sciences LLC
Co-authored papers 1
Karolinska Institutet, University College Sodertorn
Co-authored papers 1
University of California San Diego
Co-authored papers 1
University of California San Diego
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Bogazici University
Co-authored papers 1
Institute of Cellular and Organismic Biology
Co-authored papers 1
Salk Institute for Biological Studies
Co-authored papers 1
National Cancer Institute
Co-authored papers 1
University of California
Co-authored papers 1
University of New Mexico Health Sciences Center
Co-authored papers 1
Karolinska Institute
Co-authored papers 1