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Author Details

Chris Morehouse
Oncology R&D Unit
2000
44
29
PMIDPaper TitleJournal TitlePublished Year
32817076Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment.Clin Cancer Res2020
30459279Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.Ann Rheum Dis2019
31327642Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients.Clin Lung Cancer2019
31152090Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations.Sci Immunol2019
29716923Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab.Clin Cancer Res2018
29956883Baseline Plasma Cell Gene Signature Predicts Improvement in Systemic Sclerosis Skin Scores Following Treatment With Inebilizumab (MEDI-551) and Correlates With Disease Activity in Systemic Lupus Erythematosus and Chronic Obstructive Pulmonary Disease.Arthritis Rheumatol2018
30478153CD19-positive antibody-secreting cells provide immune memory.Blood Adv2018
29644082Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus.Lupus Sci Med2018
29717110IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c<sup>hi</sup>T-bet<sup>+</sup> B cells in SLE.Nat Commun2018
28819706Generation of a functional humanized Delta-like ligand 4 transgenic mouse model.Transgenic Res2017
28390867Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn's Disease: A Phase 2a Study.Gastroenterology2017
29242501High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease.Sci Rep2017
27093186Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.PLoS Genet2016
26578606BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data.Nucleic Acids Res2016
27798262Autoimmune manifestations in aged mice arise from early-life immune dysregulation.Sci Transl Med2016
27226090Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease.J Immunol2016
26315540Type I Interferon Inhibition of MicroRNA-146a Maturation Through Up-Regulation of Monocyte Chemotactic Protein-Induced Protein 1 in Systemic Lupus Erythematosus.Arthritis Rheumatol2015
26653219HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.J Transl Med2015
26348576Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.Am J Pathol2015
23434567A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.Ann Rheum Dis2014
25193511MEDI-573, alone or in combination with mammalian target of rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas.Mol Cancer Ther2014
25384217Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.J Clin Invest2014
24757153Inhibition of myogenic microRNAs 1, 133, and 206 by inflammatory cytokines links inflammation and muscle degeneration in adult inflammatory myopathies.Arthritis Rheumatol2014
24571613Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma.BMC Cancer2014
24289491MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.Pigment Cell Melanoma Res2014
24431284The plasma cell signature in autoimmune disease.Arthritis Rheumatol2014
23283488EZH2 is required for breast and pancreatic cancer stem cell maintenance and can be used as a functional cancer stem cell reporter.Stem Cells Transl Med2013
24200637Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients.Cancer Genet2013
21881594Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis.Genes Immun2012
23171592Genomic signatures characterize leukocyte infiltration in myositis muscles.BMC Med Genomics2012
22574157The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA.PLoS One2012
21860416A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth.Oncogene2012
21873529Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation.J Immunol2011
22046260Altered expression of insulin receptor isoforms in breast cancer.PLoS One2011
21803750Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway.Ann Rheum Dis2011
20346735Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production.Clin Immunol2010
20740627Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles.Muscle Nerve2010
20186858Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.Ann Neurol2010
20153794A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children.Vaccine2010
19479852Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.Arthritis Rheum2009
20948567Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus.Hum Genomics Proteomics2009
18648529Type I interferon: potential therapeutic target for psoriasis?PLoS One2008
10790289Exposure to low-frequency electromagnetic fields does not alter HSP70 expression or HSF-HSE binding in HL60 cells.Radiat Res2000
10790290Exposure of Daudi cells to low-frequency magnetic fields does not elevate MYC steady-state mRNA levels.Radiat Res2000
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Collaborators

Cellular Biomedicine Group Inc.
Co-authored papers 27
Translational and Clinical Data Sciences
Co-authored papers 24
MedImmune LLC
Co-authored papers 22
MedImmune LLC
Co-authored papers 18
Georgia Cancer Center, Medical College of Georgia
Co-authored papers 15
Massachusetts General Hospital
Co-authored papers 9
Brigham Women's Hospital, Harvard Medical School
Co-authored papers 6
Corbus Pharmaceuticals Holdings
Co-authored papers 5
BioKien LLC
Co-authored papers 5
VA Boston Healthcare System
Co-authored papers 4
Co-authored papers 2
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 2
Brigham and Women's Hospital
Co-authored papers 2
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 2
Co-authored papers 2
Brigham and Women's Hospital Department of Neurology, and Harvard Medical School
Co-authored papers 2
Parker Institute for Cancer Immunotherapy
Co-authored papers 1
Oncology R&D
Co-authored papers 1
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Harvard Partners Center For Genetics and Genomics
Co-authored papers 1
Washington University
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Nuclea Biotechnologies
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Present Address: Tempus Labs Inc.
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Hubei Engineering Research Center for Bio-enzyme Catalysis, Hubei University
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Icahn School of Medicine at Mount Sinai
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Co-authored papers 1