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Author Details

Marianne Koritzinsky
Princess Margaret Cancer Centre University Health Network
1998
72
35
PMIDPaper TitleJournal TitlePublished Year
37202533Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.Commun Biol2023
37645997Dabrafenib alters MDSC differentiation and function by activation of GCN2.bioRxiv2023
37463901Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer.Nat Commun2023
35013227Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity.Nat Commun2022
35667842Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8<sup>+</sup> T Cell Proliferation.J Immunol2022
36875717Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.Cancer Res Commun2022
36037303A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer.Clin Cancer Res2022
33440225Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21): 15-Year Evaluation of an Innovative Research Training Program.Int J Radiat Oncol Biol Phys2021
33542074Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.Clin Cancer Res2021
33675747Oxygen-independent disulfide bond formation in VEGF-A and CA9.J Biol Chem2021
33671134p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer.Cancers (Basel)2021
34401534Metformin with neoadjuvant chemoradiation to improve pathologic response in rectal cancer: A pilot phase I/II trial.Clin Transl Radiat Oncol2021
33962950NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.Sci Adv2021
34031589Mammary epithelial cells have lineage-rooted metabolic identities.Nat Metab2021
31738417Metabolic Regulation of Hippocampal Neuroprogenitor Apoptosis After Irradiation.J Neuropathol Exp Neurol2020
30655535ONECUT2 is a driver of neuroendocrine prostate cancer.Nat Commun2019
31123716Identifying the murine mammary cell target of metformin exposure.Commun Biol2019
29453322The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.Mol Cancer Res2018
29417588Targeting the CXCL12/CXCR4 pathway and myeloid cells to improve radiation treatment of locally advanced cervical cancer.Int J Cancer2018
27771366Molecular targeting of hypoxia in radiotherapy.Adv Drug Deliv Rev2017
27290740From Solo in the Silo to Strategic Training Programs.CBE Life Sci Educ2016
27959931MATE2 Expression Is Associated with Cancer Cell Response to Metformin.PLoS One2016
25347767Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.J Enzyme Inhib Med Chem2015
26384274Hypoxia and Predicting Radiation Response.Semin Radiat Oncol2015
26383681Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy.Int J Radiat Oncol Biol Phys2015
26297733Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.Cancer Res2015
26261340The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.Proc Natl Acad Sci U S A2015
24625413Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.Oncotarget2014
25351418Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.Nat Commun2014
25030372Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.Mol Cancer Res2014
24894165Hypoxia signaling and the metastatic phenotype.Curr Mol Med2014
24861559A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.Prostate Cancer Prostatic Dis2014
23471998PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.Proc Natl Acad Sci U S A2013
24045183Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.Clin Cancer Res2013
24141625Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.Clin Cancer Res2013
24247433Two phases of disulfide bond formation have differing requirements for oxygen.J Cell Biol2013
23891087Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin.Radiother Oncol2013
23830192New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia.Radiother Oncol2013
24012339The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia.Semin Radiat Oncol2013
22356756The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer.Radiother Oncol2012
21715037AMPK regulates metabolism and survival in response to ionizing radiation.Radiother Oncol2011
21665307Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction.Radiother Oncol2011
21719133Translational control is a major contributor to hypoxia induced gene expression.Radiother Oncol2011
20038797The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.J Clin Invest2010
19251093Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance.Int J Radiat Oncol Biol Phys2009
19616335Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.Radiother Oncol2009
19615771Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment.Radiother Oncol2009
19726095Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.Radiother Oncol2009
19564335Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.J Biol Chem2009
18199558Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.Cancer Res2008
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Collaborators

Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 51
Jeroen J J P van den Beucken
Radboud University Medical Center
Co-authored papers 16
Philippe Lambin
Maastricht University
Co-authored papers 16
Micha??l G Magagnin
GROW Research Institute, Maastricht University
Co-authored papers 11
Ravi N Vellanki
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
Robert G Bristow
University of Toronto
Co-authored papers 6
Ludwig Dubois
Maastricht University
Co-authored papers 6
Paul C Boutros
University of California los angeles
Co-authored papers 5
Michael Milosevic
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Renaud Seigneuric
INSERM
Co-authored papers 5
Jan Willem Voncken
Maastricht University
Co-authored papers 4
Stephen Chung
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Richard P Hill
Princess Margaret Cancer Centre
Co-authored papers 4
Albert J van der Kogel
University of Wisconsin School of Medicine and Public Health
Co-authored papers 4
Jason Moffat
University of Toronto
Co-authored papers 3
Trevor D McKee
University Health Network
Co-authored papers 3
Francesca M Buffa
University of Oxford
Co-authored papers 3
Jenna Sykes
St. Michael's Hospital, University of Toronto
Co-authored papers 3
Adrian L Harris
University of Oxford
Co-authored papers 3
Theodorus H van der Kwast
University Health Network, University of Toronto
Co-authored papers 3
Anthony M Joshua
The Kinghorn Cancer Centre, St. Vincent's Hospital Sydney
Co-authored papers 3
Kenneth C Chu
Ontario Institute for Cancer Research
Co-authored papers 3
Syed Haider
Institute of Cancer Research
Co-authored papers 3
Johan Bussink
Radboud University, Nijmegen Medical Centre
Co-authored papers 3
Melania Pintilie
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Jeff P Bruce
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Kevin R Brown
College Street, University of Toronto
Co-authored papers 2
Ryan A Rumantir
Co-authored papers 2
Pallavi Jain
SRM Institute of Science and Technology
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