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Author Details

Christopher V E Wright
Vanderbilt University
1983
188
80
PMIDPaper TitleJournal TitlePublished Year
37085274Single-Cell RNA Sequencing of Sox17-Expressing Lineages Reveals Distinct Gene Regulatory Networks and Dynamic Developmental Trajectories.Stem Cells2023
36046192Differential regulation of alternate promoter regions in <i>Sox17</i> during endodermal and vascular endothelial development.iScience2022
37829188Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development.Gastro Hep Adv2022
35787684CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.Nat Cell Biol2022
32245798Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca<sup>2+</sup> Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.Diabetes2020
32066957Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.Nat Biotechnol2020
32574594Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival.Dev Cell2020
30930126Point mutations in the PDX1 transactivation domain impair human β-cell development and function.Mol Metab2019
31201281The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.Diabetes2019
31310834Differential Cell Susceptibilities to Kras<sup>G12D</sup> in the Setting of Obstructive Chronic Pancreatitis.Cell Mol Gastroenterol Hepatol2019
31303487Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells.Curr Biol2019
30955045Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue.Diabetologia2019
31125624Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.Cell Mol Gastroenterol Hepatol2019
29396371Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.Mol Metab2018
30126902ROCK-nmMyoII, Notch and <i>Neurog3</i> gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche.Development2018
30010625The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.J Clin Invest2018
30361701Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon<sup>+</sup> α-cells.Nat Cell Biol2018
28159836c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis.Gut2018
29611808Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.Elife2018
29604291ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.Gastroenterology2018
27860540New ideas connecting the cell cycle and pancreatic endocrine-lineage specification.Cell Cycle2017
29184175Erratum: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.Nat Cell Biol2017
29058721EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.Nat Cell Biol2017
29045835A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry.Cell Rep2017
28705881Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning.Diabetes2017
28772022FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors.Genesis2017
28928395Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis.Nat Commun2017
27993987The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.Development2017
26949732Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche.Cell Mol Gastroenterol Hepatol2016
28087712PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.Genes Dev2016
27697859Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Mol Cell Biol2016
27585590Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells.Genes Dev2016
27292642Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.Cell Rep2016
26887806Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.Sci Rep2016
25511461Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning.Mech Dev2015
26534984Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.Development2015
26494792Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche.Genes Dev2015
26257608Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3.Front Neural Circuits2015
26151762The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.Elife2015
25843046PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.Stem Cell Reports2015
23645620Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.Gut2014
25371369Dominant and context-specific control of endodermal organ allocation by Ptf1a.Development2014
25060885Partial duct ligation: β-cell proliferation and beyond.Diabetes2014
24972089Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?Dev Biol2014
24943067Left-right asymmetry: advances and enigmas.Genesis2014
24574008Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.Development2014
24535035Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.Nat Commun2014
24714494In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.Elife2014
24240391Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.Nat Biotechnol2014
23999170Identification and manipulation of biliary metaplasia in pancreatic tumors.Gastroenterology2014
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Collaborators

Co-authored papers 5
Co-authored papers 4
Co-authored papers 4
Spanish National Cancer Research Centre-CNIO
Co-authored papers 2
Co-authored papers 2
Technical University of Munich, Institute of Human Genetics
Co-authored papers 2
Department of Genetics and Institute for Diabetes, University of Pennsylvania
Co-authored papers 2
Co-authored papers 2
Hadassah-Hebrew University Medical Center
Co-authored papers 2
University College London
Co-authored papers 2
National Institute of Neurological Disorders and Stroke, National Institute of Health
Co-authored papers 2
Co-authored papers 2
Duke Molecular Physiology Institute
Co-authored papers 1
Co-authored papers 1
The Ohio State University
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
National Jewish Health
Co-authored papers 1
Niels Bohr Institute, University of Copenhagen
Co-authored papers 1
Co-authored papers 1
Vollum Institute, Oregon Health & Science University
Co-authored papers 1
Co-authored papers 1
Lund University
Co-authored papers 1
university of california los angeles Jonsson Comprehensive Cancer Center.
Co-authored papers 1
Boston Children's Hospital, Harvard Medical School
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
Co-authored papers 1
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Memorial Sloan Kettering Cancer Center
Co-authored papers 1