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Author Details

Malcolm E Winkler
Indiana University Bloomington
1978
137
53
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37034771Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in <i>Streptococcus pneumoniae</i> D39.bioRxiv2023
37452010Negative regulation of MurZ and MurA underlies the essentiality of GpsB- and StkP-mediated protein phosphorylation in Streptococcus pneumoniae D39.Mol Microbiol2023
36001060Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid-shaped cells of Streptococcus pneumoniae D39.Mol Microbiol2022
35597283SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39.J Biol Chem2022
33269494Organization of peptidoglycan synthesis in nodes and separate rings at different stages of cell division of Streptococcus pneumoniae.Mol Microbiol2021
33875543Cellular Mn/Zn Ratio Influences Phosphoglucomutase Activity and Capsule Production in Streptococcus pneumoniae D39.J Bacteriol2021
34737730The Pneumococcal Divisome: Dynamic Control of <i>Streptococcus pneumoniae</i> Cell Division.Front Microbiol2021
34544281Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis.mBio2021
34475211Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall.Proc Natl Acad Sci U S A2021
34045746Undermodification cues division.Nat Chem Biol2021
32416917Chemical tools for selective activity profiling of bacterial penicillin-binding proteins.Methods Enzymol2020
32601068S1 Domain RNA-Binding Protein CvfD Is a New Posttranscriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39.J Bacteriol2020
30696736Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae.mBio2019
31265231Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division.ACS Chem Biol2019
30988030Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach.J Bacteriol2019
30833353Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39.J Bacteriol2019
31165873A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus.Nucleic Acids Res2019
30718427Movement dynamics of divisome proteins and PBP2x:FtsW in cells of <i>Streptococcus pneumoniae</i>.Proc Natl Acad Sci U S A2019
30651563The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.Nat Commun2019
29581408The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2 Streptococcus pneumoniae D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides.J Bacteriol2018
28070562Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in <i>Streptococcus pneumoniae</i> D39.mSphere2017
28249108The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity.Mol Microbiol2017
28127804Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae.Mol Microbiol2017
28941257Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39.Mol Microbiol2017
28990753Novel Electrophilic Scaffold for Imaging of Essential Penicillin-Binding Proteins in Streptococcus pneumoniae.ACS Chem Biol2017
28010038Suppression and synthetic-lethal genetic relationships of οgpsB mutations indicate that GpsB mediates protein phosphorylation and penicillin-binding protein interactions in Streptococcus pneumoniae D39.Mol Microbiol2017
27872183Roles of the Essential Protein FtsA in Cell Growth and Division in Streptococcus pneumoniae.J Bacteriol2017
26933838Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in Streptococcus pneumoniae D39.Mol Microbiol2016
263705671H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein.Biomol NMR Assign2016
27167971Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in Streptococcus pneumoniae.Microbiologyopen2016
27379215Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.Front Cell Infect Microbiol2016
25869931A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniaeâ¿¿D39 that regulates a lantibiotic biosynthesis gene cluster.Mol Microbiol2015
26303829Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms.J Bacteriol2015
25845878Profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39.Antimicrob Agents Chemother2015
25099088Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of Streptococcus pneumoniaeâ¿¿D39.Mol Microbiol2014
23354287A new structural paradigm in copper resistance in Streptococcus pneumoniae.Nat Chem Biol2013
24118410Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.Mol Microbiol2013
23860769Involvement of FtsE ATPase and FtsX extracellular loops 1 and 2 in FtsEX-PcsB complex function in cell division of Streptococcus pneumoniae D39.mBio2013
22280885Recent advances in pneumococcal peptidoglycan biosynthesis suggest new vaccine and antimicrobial targets.Curr Opin Microbiol2012
23013245Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells.Mol Microbiol2012
22909777Selective penicillin-binding protein imaging probes reveal substructure in bacterial cell division.ACS Chem Biol2012
21275153Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae.Metallomics2011
21990615Dynamic distribution of the SecA and SecY translocase subunits and septal localization of the HtrA surface chaperone/protease during Streptococcus pneumoniae D39 cell division.mBio2011
22006325Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39.Proc Natl Acad Sci U S A2011
21685290The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.J Bacteriol2011
21736639DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis.Mol Microbiol2011
21378199Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39.J Bacteriol2011
21169496The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism.J Bacteriol2011
21185072Phenotypic landscape of a bacterial cell.Cell2011
19854910Identification and characterization of noncoding small RNAs in Streptococcus pneumoniae serotype 2 strain D39.J Bacteriol2010
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Collaborators

Krystyna M Kazmierczak
International Health Management Associates Inc.
Co-authored papers 12
Daniel B Kearns
Indiana University
Co-authored papers 3
Michael S VanNieuwenhze
Co-authored papers 3
Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 2
Susan T Lovett
Brandeis University
Co-authored papers 1
Athanasios Typas
University of California san francisco
Co-authored papers 1
Robert J Nichols
Stanford University
Co-authored papers 1
Carol A Gross
University of California san francisco
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Andreas Rechtsteiner
University of California
Co-authored papers 1
Saunak Sen
University of Tennessee Health Science Center
Co-authored papers 1
Randy J Arnold
Indiana University
Co-authored papers 1
Rachna Chaba
Indian Institute of Science Education and Research (IISER) Mohali
Co-authored papers 1
Yoe-Jin Choo
Inha University
Co-authored papers 1
Angela Wong
Kaiser Permanente
Co-authored papers 1
Matylda Zietek
Co-authored papers 1
Karis J Lee
Co-authored papers 1
Douglas B Rusch
Center for Genomics and Bioinformatics, Indiana University
Co-authored papers 1
Randall K Julian
Co-authored papers 1
Sueyoung Lee
Co-authored papers 1
Jonathan C Trinidad
Indiana University
Co-authored papers 1
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
Tanja M Davidsen
Co-authored papers 1
Release 1.2