Author details

Full Name

Deborah M Muoio

Affiliation

ORCID

Career Start Year

1994

Papers

128

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37163372	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	Cell Rep	2023
36413408	Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans.	JCI insight	2023
37738954	Challenges and opportunities in targeting metabolism.		2023
36517247	Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population.	Clin J Am Soc Nephrol	2023
37060901	Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.		2023
36927960	RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.	J Clin Invest	2023
35345842	Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model.	Data in Brief	2022
35523821	Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.	Sci Rep	2022
36280113	Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism.	Molecular Metabolism	2022
36274957	Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities.	iScience	2022
35977508	Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.	Cell Reports	2022
34979330	Disruption of STIM1-mediated Ca sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.	Molecular Metabolism	2022
35028529	Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.	iScience	2022
34494555	Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle.	JCI insight	2021
33986192	Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.	JCI insight	2021
32660330	Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.	Circ Res	2020
32431698	Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.	Front Immunol	2020
32004476	Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.		2020
31813822	Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.		2020
33176135	Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.	Cell Rep	2020
30773463	Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.	Cell Metab	2019
31676389	Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial.	eBioMedicine	2019
30590691	Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.	Nucleic Acids Res	2019
30180985	Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.	Biomaterials	2019
30668551	The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.	JCI insight	2019
30778524	Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.	Cardiovasc Res	2019
29515039	Physiological mechanisms of sustained fumagillin-induced weight loss.	JCI Insight	2018
30257218	Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.	Cell Reports	2018
30016154	Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.	American Journal of Physiology - Endocrinology and Metabolism	2018
28114971	Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.	Arthritis Res Ther	2017
28559140	Bicarbonate alters cellular responses in respiration assays.	Biochemical and Biophysical Research Communications	2017
28380376	SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.	Cell Metab	2017
28982973	Metabolomic analysis of insulin resistance across different mouse strains and diets.	Journal of Biological Chemistry	2017
28170378	HDAC3 sets the timer on muscle fuel switching.	Nature Medicine	2017
27496880	Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.	Am J Physiol Heart Circ Physiol	2016
26748706	The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.	Cell Rep	2016
26998524	Mitochondrial protein hyperacetylation in the failing heart.	JCI Insight	2016
26819376	The Failing Heart Relies on Ketone Bodies as a Fuel.	Circulation	2016
27693789	Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.	Biochemical and Biophysical Research Communications	2016
25071025	Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.	Diabetes	2015
25864501	Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.		2015
25643703	Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.	Biochemical Journal	2015
25422105	Muscle-Specific Overexpression of PGC-1Î± Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction.	Diabetes	2015
26870796	Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.	EBioMedicine	2015
26185209	Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.	Circ Res	2015
26294425	SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.	Diabetes	2015
26073496	Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.	Cell Metab	2015
26540294	Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.	PLoS Genet	2015
26156077	Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of Î²-oxidation.	J Lipid Res	2015
26154055	Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.	Cell Metab	2015