Author details

Full Name

Nagarajan Pattabiraman

Affiliation

ORCID

Career Start Year

1978

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
33217941	Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.	Cancers (Basel)	2020
32324859	GlyGen data model and processing workflow.	Bioinformatics	2020
31616925	GlyGen: Computational and Informatics Resources for Glycoscience.	Glycobiology	2020
31341644	Dysregulated calcium homeostasis prevents plasma membrane repair in Anoctamin 5/TMEM16E-deficient patient muscle cells.	Cell Death Discovery	2019
28918914	Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-Î² Pathway.	Gastroenterology	2018
28266544	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.	Nature Communications	2017
28830719	Discovery of novel inhibitors of multidrug-resistant Acinetobacter baumannii.	Bioorganic and Medicinal Chemistry	2017
26810135	Impact of germline and somatic missense variations on drug binding sites.	Pharmacogenomics J	2017
25245635	Structure-function analysis of hepatitis C virus envelope glycoproteins E1 and E2.	Journal of Biomolecular Structure and Dynamics	2015
25881818	Modulating Acinetobacter baumannii biofilm development with molecules containing 3,4,5-trimethoxy-N,N',N'-trimethylbenzohydrazide moiety.	Bioorganic and Medicinal Chemistry Letters	2015
26026053	Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.	Molecular Cancer Therapeutics	2015
24117391	Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development.	Biofouling	2014
23044488	Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide.		2013
23133622	An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.	PLoS One	2012
22401958	Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase.		2012
20655881	Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes.	Biochemical Pharmacology	2010
20956529	Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1.	Journal of Biological Chemistry	2010
20385109	Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.	Brain Research	2010
18606844	Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.	Antimicrobial Agents and Chemotherapy	2008
18974393	Carprofen induction of p75NTR-dependent apoptosis via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.	Molecular Cancer Therapeutics	2008
17391648	Mutational analysis of aspartoacylase: implications for Canavan disease.	Brain Research	2007
17555331	Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.	Biochemistry	2007
16584130	Selectivity and potency of cyclin-dependent kinase inhibitors.	AAPS Journal	2006
16150867	3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation.	Mol Endocrinol	2006
17319155	Multiple enzyme activities of flavivirus proteins.	Novartis Foundation Symposium	2006
16923962	Hormonal control of androgen receptor function through SIRT1.	Molecular and Cellular Biology	2006
15993586	Identification of novel angiogenesis inhibitors.	Bioorganic and Medicinal Chemistry Letters	2005
15936754	Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination.	Experimental Cell Research	2005
15702922	Homology model of the CDK1/cyclin B complex.	Journal of Biomolecular Structure and Dynamics	2005
16061484	Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators.	Journal of Biological Chemistry	2005
15842168	A systematic search method for the identification of tightly packed transmembrane parallel alpha-helices.	Journal of Biomolecular Structure and Dynamics	2005
16116790	Web-based interface facilitating sequence-to-structure analysis of BLAST alignment reports.	BioTechniques	2005
16163449	In-silico screening using flexible ligand binding pockets: a molecular dynamics-based approach.	Journal of Computer-Aided Molecular Design	2005
15177440	Binding modes of 6,7 di-substituted 4-anilinoquinoline-3-carbonitriles to EGFR.	Bioorganic and Medicinal Chemistry Letters	2004
15358186	Teaching old drugs to kill new bugs: structure-based discovery of anti-SARS drugs.	Biochemical and Biophysical Research Communications	2004
15148333	Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions.	Journal of Experimental Medicine	2004
12887692	Molecular modeling and mutagenesis of the ligand-binding pocket of the mGlu3 subtype of metabotropic glutamate receptor.	J Neurochem	2003
12917338	Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.	Mol Cell Biol	2003
12912984	Molecular similarities in the ligand binding pockets of an odorant receptor and the metabotropic glutamate receptors.	Journal of Biological Chemistry	2003
11945127	Analysis of ligand-macromolecule contacts: computational methods.	Current Medicinal Chemistry	2002
12437378	Molecular modeling and dynamics studies of HIV-1 kissing loop structures.	Journal of Biomolecular Structure and Dynamics	2002
11125090	The RESID Database of protein structure modifications and the NRL-3D Sequence-Structure Database.	Nucleic Acids Res	2001
11193750	Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding.	Ann N Y Acad Sci	2000
10888036	Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition.	Anti-Cancer Drug Design	2000
11193777	Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report.	Ann N Y Acad Sci	2000
10379362	Uteroglobin: a novel cytokine?	Cellular and Molecular Life Sciences	1999
10508431	Occluded molecular surface analysis of ligand-macromolecule contacts: application to HIV-1 protease-inhibitor complexes.	Journal of Medicinal Chemistry	1999
9745889	Ion-RNA interactions in the RNA pseudoknot of a ribosomal frameshifting site: molecular modeling studies.	Journal of Biomolecular Structure and Dynamics	1998
9856533	Uteroglobin: physiological role in normal glomerular function uncovered by targeted disruption of the uteroglobin gene in mice.	American Journal of Kidney Diseases	1998
9571082	Use of 3D QSAR methodology for data mining the National Cancer Institute Repository of Small Molecules: application to HIV-1 reverse transcriptase inhibition.	Methods	1998