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Author Details

Bryce M Paschal
University of Virginia School of Medicine
1986
103
48
PMIDPaper TitleJournal TitlePublished Year
37077937Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells.Cancer Res Commun2023
38076829Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor.bioRxiv2023
37939374Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex.ACS Chem Biol2023
34323016ADP-ribosyltransferases, an update on function and nomenclature.FEBS J2022
34951700Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR.Prostate2022
35037691Reconstitution of the DTX3L-PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly.Biochem J2022
33976187Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.Nat Commun2021
33572475Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.Cells2021
34264286PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.Biochem J2021
32179771An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding.Sci Rep2020
33313495Role of SPTSSB-Regulated de Novo Sphingolipid Synthesis in Prostate Cancer Depends on Androgen Receptor Signaling.iScience2020
30565836A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.Aging Cell2019
31642884Characterization of the Importin-β binding domain in nuclear import receptor KPNA7.Biochem J2019
31041742Detection of ADP-Ribosylation of the Androgen Receptor Using the Recombinant Macrodomain AF1521 from Archaeoglobus fulgidus.Methods Mol Biol2019
30832896Methods in Nuclear Architecture and Transport.Methods2019
30419335Fluorescence-based quantification of nucleocytoplasmic transport.Methods2019
30419333Towards improving proximity labeling by the biotin ligase BirA.Methods2019
30305041Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.BMC Cancer2018
30404658Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer.Genome Biol2018
28525742Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.Mol Cell2017
28875501The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.Prostate2017
25452301Disruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1.Mol Cell Biol2015
26673324Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.Cell Rep2015
25839329De novo mutations in SIK1 cause a spectrum of developmental epilepsies.Am J Hum Genet2015
23503464Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells.Oncogene2014
25219851Discovery and characterization of small molecules that target the GTPase Ral.Nature2014
24563354Roles of the nucleoporin Tpr in cancer and aging.Adv Exp Med Biol2014
24523287A pathway linking oxidative stress and the Ran GTPase system in progeria.Mol Biol Cell2014
24651496Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.PLoS One2014
24045845Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation.Eur J Hum Genet2014
23995785Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.Oncogene2014
23649804Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.J Cell Biol2013
24100013Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor.Mol Cell Biol2013
21820033Post-translational modification of the androgen receptor.Mol Cell Endocrinol2012
21670151The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.Mol Cell Biol2011
20048054FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.Mol Cell Biol2010
20701745Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.BMC Cell Biol2010
20583180Petty syndrome and Fontaine-Farriaux syndrome: Delineation of a single syndrome.Am J Med Genet A2010
19116244SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.Mol Endocrinol2009
19622840Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1.J Biol Chem2009
19427017PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma.Hum Pathol2009
18270197Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.J Biol Chem2008
17389749Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.Mol Endocrinol2007
17579212Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor.Mol Endocrinol2007
17761537Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP.Mol Biol Cell2007
17325038Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions.Mol Cell Biol2007
16314397Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.Mol Biol Cell2006
16637892Scientists share nuclear secrets at Jekyll Island.Traffic2006
16282370Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.Mol Endocrinol2006
15702987Mechanisms of receptor-mediated nuclear import and nuclear export.Traffic2005
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Collaborators

Chunsong Yang
Department of Pharmacy, West China Second Hospital, Sichuan University
Co-authored papers 18
Adam Spencer
University of Virginia
Co-authored papers 13
Kasey Jividen
Center for Cell Signaling, University of Virginia
Co-authored papers 8
Larry Gerace
The Scripps Research Institute
Co-authored papers 7
Natalia Dworak
University of Virginia School of Medicine
Co-authored papers 6
Luke T Oostdyk
Center for Cell Signaling, University of Virginia
Co-authored papers 6
Li Ni
Center for Cell Signaling, University of Virginia
Co-authored papers 5
K K Pfister
School of Medicine University of Virginia
Co-authored papers 5
Mandovi Chatterjee
Center for Cell Signaling, University of Virginia
Co-authored papers 4
Aakrosh Ratan
Center for Public Health Genomics, University of Virginia
Co-authored papers 3
David L Brautigan
Co-authored papers 3
Nicholas E Sherman
University of Virginia
Co-authored papers 3
Tarek Abbas
University of Virginia
Co-authored papers 3
Catherine Dargemont
Institute of Human Genetics, UMR 9002 CNRS - University of Montpellier
Co-authored papers 2
Anindya Dutta
Co-authored papers 2
William B Dobyns
University of Minnesota
Co-authored papers 2
Ryan M Layer
Boulder and BioFrontiers Institute, University of Colorado Boulder
Co-authored papers 1
Mario Niepel
Co-authored papers 1
Erin D Jeffery
Agenus Inc, American Society for Mass Spectrometry, Hartwick College, Human Proteome Organisation, Large Scale Biology Corp, University of Virginia
Co-authored papers 1
Jeffrey Shabanowitz
University of Virginia
Co-authored papers 1
Dino Moras
Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Co-authored papers 1
Benjamin A Garcia
University of Pennsylvania
Co-authored papers 1
Susan L Christian
Seattle Children's Research Institute
Co-authored papers 1
Vera Gorbunova
University of Rochester
Co-authored papers 1
Alan Ashworth
UCSF Helen Diller Family Comprehensive Cancer Center
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Zhenjia Wang
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
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Valina L Dawson
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Release 1.2