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Author Details

Jaume Bonet
Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne
2006
45
19
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37114242A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.Oncoimmunology2023
35294435RosettaSurf-A surface-centric computational design approach.PLoS Comput Biol2022
36252041A generic framework for hierarchical de novo protein design.Proc Natl Acad Sci U S A2022
33398169Bottom-up de novo design of functional proteins with complex structural features.Nat Chem Biol2021
33705117Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design.Biochemistry2021
34834921Mutational Hotspot in the SARS-CoV-2 Spike Protein N-Terminal Domain Conferring Immune Escape Potential.Viruses2021
33937764On the use of direct-coupling analysis with a reduced alphabet of amino acids combined with super-secondary structure motifs for protein fold prediction.NAR Genom Bioinform2021
31919085Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma.Haematologica2021
33407073SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions.BMC Bioinformatics2021
32127717Author Correction: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.Nat Biotechnol2020
33575598On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF.NAR Genom Bioinform2020
32015549A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.Nat Biotechnol2020
32797645Using collections of structural models to predict changes of binding affinity caused by mutations in protein-protein interactions.Protein Sci2020
32409444De novo protein design enables the precise induction of RSV-neutralizing antibodies.Science2020
32483333Macromolecular modeling and design in Rosetta: recent methods and frameworks.Nat Methods2020
30789898Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen.PLoS Biol2019
31360335Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus: From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease.Comput Struct Biotechnol J2019
31044563Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-α7 mediated nuclear import pathway.FEBS J2019
31092198rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics.BMC Bioinformatics2019
29028891On the mechanisms of protein interactions: predicting their affinity from unbound tertiary structures.Bioinformatics2018
29980105Structure-based immunogen design-leading the way to the new age of precision vaccines.Curr Opin Struct Biol2018
29869168Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.Cancer Immunol Immunother2018
30452434Rosetta FunFolDes - A general framework for the computational design of functional proteins.PLoS Comput Biol2018
29296540ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.Oncoimmunology2017
28467807The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers.Oncotarget2017
27284060InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research.Biochem Soc Trans2016
27852777Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity.J Neurosci2016
27721464Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.Nat Commun2016
27257257ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.Science2016
27345490Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains.Sci Rep2016
26085167Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses.J Virol2015
24265221ArchDB 2014: structural classification of loops in proteins.Nucleic Acids Res2014
24603983Frag'r'Us: knowledge-based sampling of protein backbone conformations for de novo structure-based protein design.Bioinformatics2014
24629186On the use of knowledge-based potentials for the evaluation of models of protein-protein, protein-DNA, and protein-RNA interactions.Adv Protein Chem Struct Biol2014
23353828Understanding protein-protein interactions using local structural features.J Mol Biol2013
23842807iLoops: a protein-protein interaction prediction server based on structural features.Bioinformatics2013
23924802Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.MAbs2013
23221741Generation and characterization of monospecific and bispecific hexavalent trimerbodies.MAbs2013
22948662CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.Genes Dev2012
27477264Networks of ProteinProtein Interactions: From Uncertainty to Molecular Details.Mol Inform2012
21082207Prediction of a new class of RNA recognition motif.J Mol Model2011
20447706Multivalent antibodies: when design surpasses evolution.Trends Biotechnol2010
19401768In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences.PLoS One2009
17941705Characterization of protein hubs by inferring interacting motifs from protein interactions.PLoS Comput Biol2007
16374872The role of residue stability in transient protein-protein interactions involved in enzymatic phosphate hydrolysis. A computational study.Proteins2006
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