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Author Details

Markus Britschgi
Roche Pharma Research and Early Development
1999
51
34
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35159229Generation of an hiPSC-Derived Co-Culture System to Assess the Effects of Neuroinflammation on Blood-Brain Barrier Integrity.Cells2022
35659116Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta Neuropathol Commun2022
35921451Trial of Prasinezumab in Early-Stage Parkinson's Disease.N Engl J Med2022
34115198The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.Acta Neuropathol2021
37284635Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology.Free Neuropathol2021
33613545Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.Front Immunol2021
34446734Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease.Nat Commun2021
34078425Parkinson mice show functional and molecular changes in the gut long before motoric disease onset.Mol Neurodegener2021
32150624Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies.ALTEX2020
32645954Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening.Int J Mol Sci2020
32694825Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.Nat Metab2020
31235907Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nat Neurosci2019
31815671Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.Elife2019
30575769Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.Sci Rep2018
29969391Cryo-EM structure of alpha-synuclein fibrils.Elife2018
28740127Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography.Sci Rep2017
28298456Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.J Exp Med2017
27112350Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
26659895Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease.JAMA Neurol2016
27216421Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
25311587Maternal immune activation and abnormal brain development across CNS disorders.Nat Rev Neurol2014
22544647Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Mol Neurobiol2013
23448303Mind the gut: secretion of α-synuclein by enteric neurons.J Neurochem2013
23296467Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.J Exp Med2013
22429964Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ÿ plaques of Alzheimer's disease: evidence from mouse models and patients.Am J Pathol2012
22989354Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.J Neuroinflammation2012
23054689Post-marketing assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: an updated review.Adv Ther2012
21411641Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.J Neurosci2011
21886162The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Nature2011
21742799Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome.Mol Cell Proteomics2011
20030663Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells.Clin Exp Allergy2010
19064741Blood protein signature for the early diagnosis of Alzheimer disease.Arch Neurol2009
19581601Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.Proc Natl Acad Sci U S A2009
18497889The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.J Clin Invest2008
17415372Immune cells may fend off Alzheimer disease.Nat Med2007
17934472Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.Nat Med2007
17678963Systemic and acquired immune responses in Alzheimer's disease.Int Rev Neurobiol2007
17412404Cross-reactivity patterns of T cells specific for iodinated contrast media.J Allergy Clin Immunol2007
16943303Involvement of drug-specific T cells in acute drug-induced interstitial nephritis.J Am Soc Nephrol2006
16301678T cell-regulated neutrophilic inflammation in autoinflammatory diseases.J Immunol2005
15147446Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies.Allergy2004
15265952Characterization of human T cells that regulate neutrophilic skin inflammation.J Immunol2004
12528985Molecular aspects of drug recognition by specific T cells.Curr Drug Targets2003
12606784Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.Mol Pharmacol2003
12010068Cellular and molecular pathophysiology of cutaneous drug reactions.Am J Clin Dermatol2002
12569986Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides.Clin Exp Allergy2002
12130947Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells.Curr Opin Allergy Clin Immunol2002
12466124Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation.Am J Pathol2002
11159714Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells.Br J Pharmacol2001
11390425T-cell involvement in drug-induced acute generalized exanthematous pustulosis.J Clin Invest2001
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Collaborators

Tony Wyss-Coray
Stanford University
Co-authored papers 17
Henning Stahlberg
Ecole Polytechnique Federale de Lausanne (EPFL), University of Lausanne
Co-authored papers 5
Ramya Narasimhan
Stanford University School of Medicine
Co-authored papers 5
Kurt M Lucin
Eastern Connecticut State University
Co-authored papers 5
Jeffrey Kaye
Oregon Center for Aging & Technology
Co-authored papers 4
Joseph F Quinn
Oregon Health and Science University
Co-authored papers 4
Douglas Galasko
Co-authored papers 4
Hudson Johns
Stanford University School of Medicine
Co-authored papers 4
Eliezer Masliah
National Institute On Aging
Co-authored papers 4
Neill R Graff-Radford
Mayo Clinic Florida
Co-authored papers 3
Adam L Boxer
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 3
Bruce L Miller
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 3
Philipp A Jaeger
University of California
Co-authored papers 3
Anna Karydas
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 3
Andrey Loboda
Merck & Co., Inc.
Co-authored papers 2
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 2
Roland Riek
ETH Zurich
Co-authored papers 2
William H Robinson
Co-authored papers 2
Suraj Pradhan
Stanford University
Co-authored papers 2
Stephan Frank
Universitatsspital Basel
Co-authored papers 2
Badri N Vardarajan
Columbia University Irving Medical Center, New York Presbyterian Hospital
Co-authored papers 2
Rosa Rademakers
University of Antwerp
Co-authored papers 2
Ruochun Huang
RayBiotech Inc., USA RayBiotech Inc.
Co-authored papers 2
NiCole A Finch
Mayo Clinic
Co-authored papers 2
Alexei A Podtelezhnikov
Genetics and Pharmacogenomics, Merck & Co., Inc.
Co-authored papers 2
Jerome A Yesavage
Stanford University School of Medicine
Co-authored papers 2
Bradley F Boeve
Mayo Clinic Rochester
Co-authored papers 2
Elizabeth Head
University of California Irvine
Co-authored papers 2
Lindsay A Farrer
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 2
David S Knopman
Mayo Clinic Rochester
Co-authored papers 2
Release 1.2