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Author Details

Jeremy S Caldwell
Sirna Therapeutics a former subsidiary of Merck & Co., Inc.
1994
48
28
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
30605011Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.Am J Physiol Gastrointest Liver Physiol2019
30991218Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2.Mol Ther Nucleic Acids2019
29130735Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.J Cardiovasc Pharmacol Ther2018
30158152Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.Sci Transl Med2018
30141927Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).J Med Chem2018
29153987Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.Stem Cell Reports2017
22355095Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.J Lipid Res2012
21974780Parsimonious discovery of synergistic drug combinations.ACS Chem Biol2011
19854890Identification and characterization of a small molecule antagonist of human VPAC(2) receptor.Mol Pharmacol2010
20502647HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.Curr Chem Genomics2010
19059193An intracellular conformational sensor assay for Abl T315I.Anal Biochem2009
20020055Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening.PLoS One2009
19690143Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.Cancer Res2009
19328766A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.Anal Biochem2009
19482004Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.Anal Biochem2009
19286662Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.J Biol Chem2009
18302737Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.Genome Biol2008
20161828Cellular Ser/Thr-kinase assays using generic peptide substrates.Curr Chem Genomics2008
18854154Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.Cell2008
18576636In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.J Am Chem Soc2008
18579783In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.Proc Natl Acad Sci U S A2008
18593374An interview with Jeremy S. Caldwell.Assay Drug Dev Technol2008
17161679Cancer cell-based genomic and small molecule screens.Adv Cancer Res2007
17980596Human Cep192 is required for mitotic centrosome and spindle assembly.Curr Biol2007
17257639Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening.Virology2007
17512569Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes.Virology2007
170350194-Aminopyrimidines as novel HIV-1 inhibitors.Bioorg Med Chem Lett2007
16352537"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection.J Virol2006
17125181Learning from the data: mining of large high-throughput screening databases.J Chem Inf Model2006
16782337Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.Bioorg Med Chem Lett2006
16524731Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.Bioorg Med Chem Lett2006
16480865Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.Bioorg Med Chem Lett2006
16464578Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.Bioorg Med Chem Lett2006
16492761An efficient rapid system for profiling the cellular activities of molecular libraries.Proc Natl Acad Sci U S A2006
16458503Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.Bioorg Med Chem Lett2006
16632349Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.Bioorg Med Chem Lett2006
15713410Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.Bioorg Med Chem Lett2005
16199156Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.Bioorg Med Chem Lett2005
16093555Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities.J Biomol Screen2005
14764605PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter.J Biol Chem2004
15265741A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors.Anal Biochem2004
14990790Identification of p53 regulators by genome-wide functional analysis.Proc Natl Acad Sci U S A2004
12529389Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.Mol Cell Biol2003
14514886Genome-scale functional profiling of the mammalian AP-1 signaling pathway.Proc Natl Acad Sci U S A2003
14522048Ontology recapitulates physiology.Chem Biol2003
14557485Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.J Clin Endocrinol Metab2003
12581711Fulfilling the promise: drug discovery in the post-genomic era.Drug Discov Today2003
8302854Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.Proc Natl Acad Sci U S A1994
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Collaborators

Genomics Institute of the Novartis Research Foundation
Co-authored papers 10
The Scripps Research Institute
Co-authored papers 8
Genomics Institute of the Novartis Research Foundation
Co-authored papers 7
Harvard Medical School
Co-authored papers 6
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Merck & Co., Inc.
Co-authored papers 4
Co-authored papers 3
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Co-authored papers 3
Merck & Co., Inc.
Co-authored papers 3
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Co-authored papers 2
Genomics Institute of the Novartis Research Foundation
Co-authored papers 2
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
a division of The Scripps Research Institute La Jolla
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Prestige BioPharma Ltd
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
National Institutes of Health, National Center for Advancing Translational Sciences
Co-authored papers 1
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
Joint Center for Structural Genomics
Co-authored papers 1
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VIB-Center for Cancer Biology
Co-authored papers 1
The Scripps Research Institute
Co-authored papers 1
Institute of Molecular Genetics of the Czech Academy of Sciences
Co-authored papers 1
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Co-authored papers 1
United States Army Medical Research Institute of Infectious Diseases
Co-authored papers 1
Sanford-Burnham Medical Research Institute
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Clinical Medical Research Center of Hepatic Surgery at Hubei Province
Co-authored papers 1
The Salk Institute for Biological Studies
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