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Author Details

Claes B Wollheim
Lund University
1973
363
97
PMIDPaper TitleJournal TitlePublished Year
34847289Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk.FEBS J2023
36979492Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane.Biomolecules2023
37277321CDN1163, an activator of sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic β-cells.Br J Pharmacol2023
35948367Islet Gene View-a tool to facilitate islet research.Life Sci Alliance2022
34759311Elevated circulating follistatin associates with an increased risk of type 2 diabetes.Nat Commun2021
33826910Voices: Insulin and beyond.Cell Metab2021
33589583Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.Transl Psychiatry2021
32198214Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells.Diabetes2020
32960311Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells.Diabetologia2020
30293774Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells.Cell Metab2019
30917339Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.J Mol Endocrinol2019
28923347Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production.Mol Cell Endocrinol2018
29890211Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.Mol Cell Endocrinol2018
29185012Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.Diabetologia2018
29229616Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.Diabetes2018
29186426The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.Hum Mol Genet2018
28585545Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.Nat Commun2017
28137482Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ÿ-cells: A potential beneficial effect in the pre-diabetic state?Int J Biochem Cell Biol2017
28332581Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.Sci Rep2017
28154371Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.Exp Mol Med2017
28237718Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.Mol Cell Endocrinol2017
28615356Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.Sci Transl Med2017
26792861Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4ο) Is Vital to Beta-cell Function.J Biol Chem2016
30603252Is zinc an intra-islet regulator of glucagon secretion?Diabetol Int2016
27456623Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430.Diabetes2016
27565711Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.FASEB J2016
27155871Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.Diabetologia2016
27338624CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.Diabetologia2016
27279209Physiology: Microbial signals to the brain control weight.Nature2016
25548283Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.J Biol Chem2015
26583319Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress.Cell Death Dis2015
26742564Thrombin stimulates insulin secretion via protease-activated receptor-3.Islets2015
25852001Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.Am J Physiol Endocrinol Metab2015
25849270Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?Nat Med2015
25731850Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.Biochem J2015
25489054Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.Hum Mol Genet2015
24603685Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.PLoS Genet2014
25201977Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.Proc Natl Acad Sci U S A2014
25015099TCF7L2 is a master regulator of insulin production and processing.Hum Mol Genet2014
23282133Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.Biochem J2013
23879380DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.BMC Med Genet2013
23939247Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.Mol Cell Endocrinol2013
23246353Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction.Mol Cell Endocrinol2013
21784130Mitochondrial signals drive insulin secretion in the pancreatic β-cell.Mol Cell Endocrinol2012
22965295A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.Diabetologia2012
23140642Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.Cell Metab2012
22801105Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.Mol Cell Endocrinol2012
22809973Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.Biochim Biophys Acta2012
22768844A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.Cell Metab2012
22570331Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.Mol Endocrinol2012
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Jorge Ferrer
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Ioannis Xenarios
University of Lausanne
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Claes Ladenvall
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Brigham H Mecham
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Marju Orho-Melander
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Peter Almgren
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