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Author Details

Lars Lannfelt
1988
368
83
PMIDPaper TitleJournal TitlePublished Year
37542303The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy.2023
36253511Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease.2023
38084203A light at the end of the tunnel - from mutation identification to a potential treatment for Alzheimer's disease.2023
37559953Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils.2023
36994753The amyloid-β pathway in Alzheimer's disease: a plain language summary.Neurodegener Dis Manag2023
35120450Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia.BMC Genomics2022
36343257Aβ and tau prions feature in the neuropathogenesis of Down syndrome.Proc Natl Acad Sci U S A2022
35598024Correction to: A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody.Alzheimers Res Ther2022
34380771The <i>Uppsala APP</i> deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.Sci Transl Med2021
33971986Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.Acta neuropathologica communications2021
33848613Characterization of monomeric and soluble aggregated Aβ in Down's syndrome and Alzheimer's disease brains.Neuroscience Letters2021
33727701Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.Nat Genet2021
34091073Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease.Mol Cell Neurosci2021
33865446A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody.Alzheimers Res Ther2021
34579778Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta.Translational Neurodegeneration2021
34737044ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.Neurobiology of Disease2021
34456336The Amyloid-β Pathway in Alzheimer's Disease.Mol Psychiatry2021
33230300Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.Nat Genet2020
32154904[Alzheimer's disease - the most common cause of dementia].Lakartidningen2020
31654039Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals.European Journal of Human Genetics2020
33236886Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain.ACS Chemical Neuroscience2020
31386938Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes.Neurobiology of Aging2019
30374072Mosaic loss of chromosome Y in leukocytes matters.Nature Genetics2019
30614806Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers.J Alzheimers Dis2019
30820047Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet2019
29793530Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.Alzheimer's Research and Therapy2018
28557010Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury.Brain Pathology2018
29934873Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.Acta Neuropathologica2018
29858078CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.Mol Ther Nucleic Acids2018
29853653Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition.2018
29311311Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.Proc Natl Acad Sci U S A2018
29592816The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death.Journal of Neuroinflammation2018
29360107Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.Sci Data2018
28079014Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease.Journal of the International Neuropsychological Society2017
28341696A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.Diabetes2017
28416818Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.Nat Genet2017
28714976Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.Nat Genet2017
28886705Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease.BMC Geriatrics2017
28932173Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.Biological Procedures Online2017
28747752Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.Nat Genet2017
28566273An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.Diabetes2017
29040868Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.Atherosclerosis2017
28394258Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.J Clin Invest2017
29228971Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes.Journal of Neuroinflammation2017
29257133Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.Sci Data2017
26961542Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.Cellular and Molecular Neurobiology2017
28069541A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging.NeuroImage2017
28265256Decreased HHV-6 IgG in Alzheimer's Disease.Frontiers in Neurology2017
27743932Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [C]ABP688 PET imaging and ex vivo immunoblotting.Neuropharmacology2017
28042336Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.Theranostics2017
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