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Author Details

Peter D Adams
Sanford Burnham Prebys Medical Discovery Institute
1991
124
54
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36264490Detection of TP53 Mutation in Acute Myeloid Leukemia by RT-PCR-Based Sanger Sequencing.Methods Mol Biol2023
37589340Post-translational modifications of ATG8 proteins - an emerging mechanism of autophagy control.J Cell Sci2023
37650879Hematopoiesis: a BETter understanding.EMBO Rep2023
37821702Apoptotic stress causes mtDNA release during senescence and drives the SASP.Nature2023
37117791Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging.Nat Aging2023
37115668PSGL-1 attenuates early TCR signaling to suppress CD8<sup>+</sup> T cell progenitor differentiation and elicit terminal CD8<sup>+</sup> T cell exhaustion.Cell Rep2023
36973293Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells.Nat Commun2023
37400722Spatial mapping of cellular senescence: emerging challenges and opportunities.Nat Aging2023
37292952Dynamic enhancer interactome promotes senescence and aging.bioRxiv2023
36669469Is aging a "Retro"spective event?Cell2023
35131874Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma.Mol Cancer Ther2022
35851616ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16<sup>INK4a</sup> levels.Nat Cell Biol2022
36154662Upregulation of PD-L1 in Senescence and Aging.Mol Cell Biol2022
34983954Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.Nat Cell Biol2022
33431824BRD4-mediated repression of p53 is a target for combination therapy in AML.Nat Commun2021
32001510Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.Genes Dev2020
30901352The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.PLoS Pathog2019
31675495Cellular Senescence: Defining a Path Forward.Cell2019
31399573PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.Nat Commun2019
31633821Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.EMBO J2019
30737259Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.EMBO J2019
28967905AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.Oncogene2018
30241605DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.Mol Cell2018
30122553A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3.Cell Metab2018
27986499Targeting chromatin aging - The epigenetic impact of longevity-associated interventions.Exp Gerontol2017
28351423Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment.Genome Biol2017
28351383Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.Genome Biol2017
28981850Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.Nucleic Acids Res2017
28976970Cytoplasmic chromatin triggers inflammation in senescence and cancer.Nature2017
28647344Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function.J Invest Dermatol2017
28607920Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA.Stem Cell Investig2017
28543539DNA damage marker phosphorylated histone H2AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity.Histopathology2017
26821228Critical Parameters for Efficient Sonication and Improved Chromatin Immunoprecipitation of High Molecular Weight Proteins.PLoS One2016
26654219Mammalian autophagy degrades nuclear constituents in response to tumorigenic stress.Autophagy2016
26286607P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.J Gerontol A Biol Sci Med Sci2016
27423868ChIP-Sequencing to Map the Epigenome of Senescent Cells Using Benzonase Endonuclease.Methods Enzymol2016
27261480Senescence Can Be BETter without the SASP?Cancer Discov2016
27457071Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.Genome Biol2016
26833731MLL1 is essential for the senescence-associated secretory phenotype.Genes Dev2016
26774282Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.Mol Cell2016
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
26848154Mitochondria are required for pro-ageing features of the senescent phenotype.EMBO J2016
25815427Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.J Invest Dermatol2015
26299965Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest.Cell Rep2015
26524528Autophagy mediates degradation of nuclear lamina.Nature2015
26159857Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.Nat Commun2015
26046760Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer.Cell Stem Cell2015
26178707Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.J Invest Dermatol2015
24097338EZH2 in normal and malignant hematopoiesis.Leukemia2014
25512559HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.Genes Dev2014
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Stephen J Elledge
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Ashok R Venkitaraman
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Norman E Sharpless
National Cancer Institute
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Collaborators

Tony McBryan
The Beatson Institute
Co-authored papers 17
Shelley L Berger
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 13
Neil A Robertson
Beatson Institute for Cancer Research and the University of Glasgow
Co-authored papers 11
John J Cole
College of Medicine, University of Glasgow
Co-authored papers 8
Claire Brock
Beatson Institute for Cancer Research and University of Glasgow
Co-authored papers 8
Ronen Marmorstein
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 7
William Clark
Cancer Research UK Beatson Institute
Co-authored papers 7
J. Wade Harper
Harvard Medical School
Co-authored papers 6
Greg Donahue
Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania
Co-authored papers 6
William R Sellers
Co-authored papers 4
Aaron Havas
University of Arizona
Co-authored papers 4
Diana van Heemst
Co-authored papers 3
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 3
Tina Wang
Harvard University
Co-authored papers 3
Adam E Field
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Iain A McNeish
Ovarian Cancer Action Research Centre, Imperial College London
Co-authored papers 2
Jan P Erzberger
UT Southwestern Medical Center
Co-authored papers 2
Evripidis Gavathiotis
Albert Einstein College of Medicine
Co-authored papers 2
Ghulam Mohammad Rather
Islamic University of Science and Technology
Co-authored papers 2
Roland L Dunbrack
Fox Chase Cancer Center
Co-authored papers 2
Jun Qin
Co-authored papers 2
Benjamin A Garcia
University of Pennsylvania
Co-authored papers 2
Richard R Meehan
Institute of Genetics and Molecular Medicine, University of Edinburgh
Co-authored papers 2
Malene Hansen
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Holly M Brown-Borg
University of North Dakota
Co-authored papers 2
Pieternella E Slagboom
Co-authored papers 2
Masashi Narita
Co-authored papers 2
Ian G Mills
Queen's University Belfast
Co-authored papers 1
Manish K Aghi
University of California san francisco
Co-authored papers 1
Richard A Miller
University of Michigan School of Medicine ann arbor
Co-authored papers 1
Release 1.2