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Author Details

Alexandre F R Stewart
1989
146
56
PMIDPaper TitleJournal TitlePublished Year
35259833N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer's disease and schizophrenia models.Neural Regeneration Research2022
36278405Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.Hypertension2022
35865523Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2-Null Mice.Frontiers in Immunology2022
35336966Revisiting the MMTV Zoonotic Hypothesis to Account for Geographic Variation in Breast Cancer Incidence.Viruses2022
34760935IRF2BP2 3'UTR Polymorphism Increases Coronary Artery Calcification in Men.Frontiers in Cardiovascular Medicine2021
34015491Ketamine's schizophrenia-like effects are prevented by targeting PTP1B.Neurobiol Dis2021
34044147Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.Neurobiol Dis2021
32788467Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models.Neural Regeneration Research2021
34547032Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.PLoS Genet2021
32610340Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice.2020
32094367Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors.Nature Communications2020
31915254Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.J Neurosci2020
32654539Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.Circulation2020
32594039Activation of tyrosine phosphatases in the progression of Alzheimer's disease.Neural Regeneration Research2020
30897348Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.Circ Genom Precis Med2019
29557374Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury.Neural Regeneration Research2018
28158393Partitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity.Cardiovascular Research2017
28769762Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.Frontiers in Cellular Neuroscience2017
28461624Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions.Circulation2017
28852125IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care.Scientific Reports2017
28566218Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.Lancet Diabetes Endocrinol2017
29029846Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.Lancet Neurol2017
29239311Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery.Neural Regeneration Research2017
27815828Transcriptomic Signature of Atherosclerosis in the Peripheral Blood: Fact or Fiction?Current Atherosclerosis Reports2016
26822151Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease.Nature Communications2016
26220701Increased genetic risk for obesity in premature coronary artery disease.European Journal of Human Genetics2016
27731410No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.Sci Rep2016
26617239Endothelial Gata5 transcription factor regulates blood pressure.Nat Commun2015
25754825Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling.Neuron2015
25623533Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound.Biochemical and Biophysical Research Communications2015
25533968Making sense of genome-wide association studies: integrating genetic variation with gene expression to derive functional mechanisms underlying disease risk.Circulation2015
25487149Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Nature2015
25762803Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.J Am Heart Assoc2015
27066539Genetic analysis for a shared biological basis between migraine and coronary artery disease.Neurol Genet2015
26390057Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Nat Genet2015
26043746Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis.Circulation: Cardiovascular Genetics2015
26343387A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.Nat Genet2015
264877559p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.Circulation2015
26195219IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.Circ Res2015
25977570Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease.Arterioscler Thromb Vasc Biol2015
25225679Adiposity significantly modifies genetic risk for dyslipidemia.Journal of Lipid Research2014
25667094Atherosclerosis: a longue durée approach.Global Heart2014
25667093Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes.Global Heart2014
25667090Genomic correlates of atherosclerosis in ancient humans.Global Heart2014
24381275LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.Journal of Neuroscience2014
24767997SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.Cell Rep2014
24675659Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.Arteriosclerosis, Thrombosis, and Vascular Biology2014
25033284Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.PLoS Genet2014
24582386Is atherosclerosis fundamental to human aging? Lessons from ancient mummies.Journal of Cardiology2014
25180781Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies.PLoS ONE2014
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Vagelos College of Physicians and Surgeons, Columbia University
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Medical Clinic V, University of Heidelberg
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William Harvey Research Institute, Queen Mary University of London
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Brigham and Women's Hospital, Harvard Medical School
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University of Oxford
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Heidelberg University
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Baylor College of Medicine
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University of Bristol
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Duke Molecular Physiology Institute
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Lee Kong Chian School of Medicine, Nanyang Technological University
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London NorthWest Healthcare NHS Trust
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