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Author Details

Michael W Devereaux
University of Colorado School of Medicine
1989
43
26
PMIDPaper TitleJournal TitlePublished Year
37976384LRH-1 agonist DLPC through STAT6 promotes macrophage polarization and prevents parenteral nutrition-associated cholestasis in mice.Hepatology2024
36633484Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.Hepatol Commun2023
37647292Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.PLoS One2023
37173326Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.Sci Rep2023
37468479Publisher Correction: Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.Sci Rep2023
36848082Stat3 role in the protective effect of FXR Agonist in parenteral nutrition-associated cholestasis.Hepatol Commun2023
34387888Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.Hepatology2022
34664730Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.JPEN J Parenter Enteral Nutr2022
34310734NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.Hepatology2021
34774795miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis.J Biol Chem2021
31832574Up-regulation of miR-let7a-5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis.Hepatol Commun2019
29643332Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.Nat Commun2018
25329595Specific microbiome changes in a mouse model of parenteral nutrition associated liver injury and intestinal inflammation.PLoS One2014
24107776Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease.Sci Transl Med2013
22120983Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury.Hepatology2012
18596569Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol.Pediatr Res2008
17659596Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis.Hepatology2007
16962932Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.Free Radic Biol Med2006
16819400"Let there be bile"--understanding hepatic injury in cholestasis.J Pediatr Gastroenterol Nutr2006
15722564Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration.J Lipid Res2005
15902097Increased susceptibility of fat-laden Zucker-rat hepatocytes to bile acid-induced oncotic necrosis: an in vitro model of steatocholestasis.J Lab Clin Med2005
16056106Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids.J Pediatr Gastroenterol Nutr2005
15642733Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes.J Biol Chem2005
14764912Beta-carotene prevents bile acid-induced cytotoxicity in the rat hepatocyte: Evidence for an antioxidant and anti-apoptotic role of beta-carotene in vitro.Pediatr Res2004
15528030Enrichment of rat hepatic organelles by vitamin E administered subcutaneously.Free Radic Biol Med2004
12006578Nitric oxide ameliorates hydrophobic bile acid-induced apoptosis in isolated rat hepatocytes by non-mitochondrial pathways.J Biol Chem2002
11264436Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids.Pediatr Res2001
11230742Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition.Hepatology2001
10739750Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis.Toxicol Appl Pharmacol2000
9727720Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated rat.Pediatr Res1998
9428230Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat.Gastroenterology1998
9741584The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria.Free Radic Biol Med1998
8825797alpha-tocopherol ameliorates oxidant injury in isolated copper-overloaded rat hepatocytes.Pediatr Res1996
8928800Hepatic oxidant injury and glutathione depletion during total parenteral nutrition in weanling rats.Am J Physiol1996
7557092Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids.Gastroenterology1995
7770468Developmental changes in newborn lamb brain mitochondrial activity and postasphyxial lipid peroxidation.Proc Soc Exp Biol Med1995
7958693Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis.Gastroenterology1994
8387948Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes.Hepatology1993
8390379Abnormal hepatic mitochondrial respiration and cytochrome C oxidase activity in rats with long-term copper overload.Gastroenterology1993
1770317Effect of dietary lipid and vitamin E on mitochondrial lipid peroxidation and hepatic injury in the bile duct-ligated rat.J Lipid Res1991
2394327Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency.Gastroenterology1990
2395066Effect of vitamin E on transport processes in isolated rat hepatocytes.J Pediatr Gastroenterol Nutr1990
2919118Copper toxicity and lipid peroxidation in isolated rat hepatocytes: effect of vitamin E.Pediatr Res1989
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Collaborators

Ronald J Sokol
Digestive Health Institute, Children's Hospital Colorado
Co-authored papers 43
Aimee L Anderson
University of Colorado School of Medicine
Co-authored papers 10
Karim C El Kasmi
Boehringer Ingelheim Pharma GmbH & Co. KG
Co-authored papers 9
David J Orlicky
University of Colorado School of Medicine
Co-authored papers 8
Swati Ghosh
University of Colorado School of Medicine
Co-authored papers 7
Colin T Shearn
University of Colorado School of Medicine
Co-authored papers 4
Angelo D'Alessandro
University of Colorado Anschutz Medical Campus
Co-authored papers 3
Mark A Lovell
University of Kentucky
Co-authored papers 2
Julie A Reisz
University of Colorado Anschutz Medical Campus
Co-authored papers 2
Sarah Gehrke
University of Colorado Anschutz Medical Campus
Co-authored papers 1
Clyde J Wright
University of Colorado School of Medicine and Children's Hospital Colorado
Co-authored papers 1
Release 1.2