Author details

Full Name

Larry A Sklar

Affiliation

ORCID

Career Start Year

1975

Papers

334

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37383263	Editorial: Environmental contaminants in aquatic systems and chemical safety for environmental and human health, volume II.		2023
37558176	The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1Î² and IL-10 expression from immune cell culture.		2023
35385793	A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions.	SLAS Discovery	2022
33977234	Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.	FASEB BioAdvances	2021
32044470	Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity.	Seminars in Cancer Biology	2021
33555272	RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.	J Clin Invest	2021
33330842	Virtual and <i>In Vitro</i> Antiviral Screening Revive Therapeutic Drugs for COVID-19.	ACS Pharmacol Transl Sci	2020
32567455	A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions.	SLAS Discov	2020
32902275	Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.	J Med Chem	2020
30898518	Clioquinol: To harm or heal.	Pharmacology and Therapeutics	2019
31706983	A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling.	Cell Chem Biol	2019
29232168	High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining.	SLAS Discovery	2018
30532236	Far away from the lamppost.	PLoS Biol	2018
29992797	Evaluating integrin activation with time-resolved flow cytometry.	Journal of Biomedical Optics	2018
29938597	Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations.	Autophagy	2018
29567993	Unexplored therapeutic opportunities in the human genome.	Nat Rev Drug Discov	2018
29177837	High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.	Methods Mol Biol	2018
29301866	Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.	J Exp Med	2018
29746793	High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL.	SLAS Discov	2018
29608398	A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry.	SLAS Discovery	2018
29472638	Unexplored therapeutic opportunities in the human genome.	Nat Rev Drug Discov	2018
29746086	Activation of Rho Family GTPases by Small Molecules.	ACS Chem Biol	2018
29842834	High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen.	SLAS Discovery	2018
29677518	Retraction Notice to: ATP Hydrolysis-Dependent Disassembly of the 26S Proteasome Is Part of the Catalytic Cycle.	Cell	2018
27903890	Pharos: Collating protein information to shed light on the druggable genome.	Nucleic Acids Res	2017
28398460	TIN-X: target importance and novelty explorer.	Bioinformatics	2017
27671528	Novel ABCG2 Antagonists Reverse Topotecan-Mediated Chemotherapeutic Resistance in Ovarian Carcinoma Xenografts.	Molecular Cancer Therapeutics	2016
25641607	Relationship of light scatter change and Cdc42-regulated actin status.	Cytometry Part B - Clinical Cytometry	2016
27239230	Badapple: promiscuity patterns from noisy evidence.	J Cheminform	2016
27129155	Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia.	Oncotarget	2016
27316999	A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3',5'-Cyclic Adenosine Monophosphate Efflux.	Methods in Molecular Biology	2016
27463566	Targeting efflux pumps to overcome antifungal drug resistance.	Future Medicinal Chemistry	2016
26442911	Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.	J Biomol Screen	2016
28276667	Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.	Journal of Biomedical Research	2016
27641501	Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.	Cell	2016
26071482	A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.	Clin Cancer Res	2015
25805180	Flow Cytometry: Impact on Early Drug Discovery.	Journal of Biomolecular Screening	2015
25378583	FRET detection of lymphocyte function-associated antigen-1 conformational extension.	Mol Biol Cell	2015
25800855	Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein.	Methods in Molecular Biology	2015
25511480	The evaluation of thioridazine as a hematopoietic progenitor cell mobilizing agent in healthy human subjects.	Journal of Clinical Pharmacology	2015
25381253	A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants.	Journal of Biomolecular Screening	2015
26558612	Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.	PLoS One	2015
26046436	Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.	Cell	2015
26503418	Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.	Nature Communications	2015
26206334	R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.	Molecular Cancer Therapeutics	2015
26247207	A Pan-GTPase Inhibitor as a Molecular Probe.	PLoS ONE	2015
24926233	Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectives.	Frontiers in Molecular Neuroscience	2014
25367365	Carbon monoxide down-regulates Î±4Î²1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.	BMC Immunology	2014
25350399	An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins.	PLoS One	2014
24409953	The University of New Mexico Center for Molecular Discovery.	Comb Chem High Throughput Screen	2014