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Author Details

Ivan Sadowski
University of British Columbia
1984
71
34
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36631514Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.Sci Rep2023
37515158Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.Viruses2023
37671866CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells.J Virol2023
36690785TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.Commun Biol2023
33345679A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization.SLAS Discov2021
34849833TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.Genetics2021
31608481Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens.Med Res Rev2020
33228394Management of inadvertent template contamination in production of oligonucleotide qPCR reagents.Biotechniques2020
31129856Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs.Cell Mol Life Sci2019
31506296Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.J Biol Chem2019
29246970Compounds producing an effective combinatorial regimen for disruption of HIV-1 latency.EMBO Mol Med2018
26984732HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site.J Virol2016
24502247Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB.Retrovirology2014
23408629A doubly fluorescent HIV-1 reporter shows that the majority of integrated HIV-1 is latent shortly after infection.J Virol2013
24116200An upstream YY1 binding site on the HIV-1 LTR contributes to latent infection.PLoS One2013
23977017Whole genome duplication and enrichment of metal cation transporters revealed by de novo genome sequencing of extremely halotolerant black yeast Hortaea werneckii.PLoS One2013
23674503The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update.Database (Oxford)2013
22124158Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae.Mol Cell Biol2012
21813151Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.Virology2011
22020221The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response.FEBS Lett2011
20428315PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae.Database (Oxford)2010
20584076Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae.FEBS J2010
18613257Dominant marker vectors for selecting yeast mating products.Yeast2008
18976654Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus.FEBS Lett2008
18691027Factors controlling chromatin organization and nucleosome positioning for establishment and maintenance of HIV latency.Curr HIV Res2008
17515203Identification of protein interaction antagonists using the repressed transactivator two-hybrid system.Biotechniques2007
17546494Induction of chromosomally integrated HIV-1 LTR requires RBF-2 (USF/TFII-I) and Ras/MAPK signaling.Virus Genes2007
17315265Disintegrator vectors for single-copy yeast chromosomal integration.Yeast2007
16574111Cytochrome b(5) is a major reductant in vivo of human indoleamine 2,3-dioxygenase expressed in yeast.FEBS Lett2006
15767439TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.J Virol2005
16223582TFII-I and USF (RBF-2) regulate Ras/MAPK-responsive HIV-1 transcription in T cells.Eur J Cancer2005
15976286Problems with co-funding in Canada.Science2005
15781865Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements.Proc Natl Acad Sci U S A2005
15175151A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.Mol Cell2004
12520306Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.Nature2003
13679852Mitogen-responsive expression of RhoB is regulated by RNA stability.Oncogene2003
12864730Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.Biochem J2003
11810026Organization and expression of the Cyr61 gene in normal human fibroblasts.J Biomed Sci2002
11447261A two-hybrid system for transactivator bait proteins.Proc Natl Acad Sci U S A2001
10825185Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms.Mol Cell Biol2000
10805731Multiple signals regulate GAL transcription in yeast.Mol Cell Biol2000
10494039Purification of RBF-2, a transcription factor with specificity for the most conserved cis-element of naturally occurring HIV-1 LTRs.J Biomed Sci1999
10360183GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.Mol Cell1999
9671221Distinct clustering of HIV type 1 sequences derived from injection versus noninjection drug users in Vancouver, Canada.AIDS Res Hum Retroviruses1998
9473286Plasmids for one- and two-hybrid analysis in mammalian cells.Anal Biochem1998
9866677Mapping a protein-binding site on straightened DNA by atomic force microscopy.Anal Biochem1998
9658089Naturally occurring human immunodeficiency virus type 1 long terminal repeats have a frequently observed duplication that binds RBF-2 and represses transcription.J Virol1998
9151949Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p.Eur J Biochem1997
8648743Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity.J Virol1996
9000143Ras-responsiveness of the HIV-1 LTR requires RBF-1 and RBF-2 binding sites.Oncogene1996
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Collaborators

Tony Pawson
Co-authored papers 7
Martin Hirst
University of British Columbia
Co-authored papers 7
Viviana Simon
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Michael F Moran
Hospital for Sick Children, University of Toronto
Co-authored papers 3
Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 3
Michael S Kobor
University of British Columbia
Co-authored papers 2
P Richard Harrigan
Co-authored papers 2
Nicole Hawe
University of British Columbia
Co-authored papers 2
Chris Stark
The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Bobby-Joe Breitkreutz
The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Robert G Roeder
the Rockefeller University
Co-authored papers 2
Ashton Breitkreutz
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Co-authored papers 2
Kristy Dever
BC Children's Hospital Research Institute, University of British Columbia
Co-authored papers 1
Deborah A Nickerson
University of Washington
Co-authored papers 1
Richard W Wozniak
University of Alberta
Co-authored papers 1
Steven J M Jones
University of British Columbia
Co-authored papers 1
Michel L Tremblay
Co-authored papers 1
Linda Z Penn
University of Toronto
Co-authored papers 1
Metka Lenassi
Institute of Biochemistry and Molecular Genetics, University of Ljubljana
Co-authored papers 1
David W Andrews
Sunnybrook Research Institute, University of Toronto
Co-authored papers 1
Gian Luca Negri
British Columbia Cancer Research Institute
Co-authored papers 1
Mary Shen
BC Children's Hospital Research Institute, University of British Columbia
Co-authored papers 1
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 1
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Maria J Aristizabal
Queen's University
Co-authored papers 1
Joris J Benschop
Center for Molecular Medicine, University Medical Center Utrecht
Co-authored papers 1
Paul W Sternberg
California Institute of Technology
Co-authored papers 1
Jesper Q Svejstrup
Panum Institute, University of Copenhagen
Co-authored papers 1
Richard A Rachubinski
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Release 1.2