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Author Details

Stephen A McMahon
University of St Andrews
1998
48
25
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37747760Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open.Nucleic Acids Res2023
34724608Kinetic and Structural Characterization of Sialidases (Kdnases) from Ascomycete Fungal Pathogens.ACS Chem Biol2021
33590098The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.Nucleic Acids Res2021
33391858Dissecting the Mechanism of (<i>R</i>)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry.ACS Catal2020
31980625Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.Nat Commun2020
31942067An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.Nature2020
29735649Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides.Proc Natl Acad Sci U S A2018
30307091New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes.Chemistry2018
29685972Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.Philos Trans R Soc Lond B Biol Sci2018
29051530Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.Nat Commun2017
26642178Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme.Bioorg Chem2016
25795774Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate.J Biol Chem2015
24501222Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation.Blood2014
24989327A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18Fâ¿¿fluorination of a RGD peptide under ambient aqueous conditions.Angew Chem Int Ed Engl2014
23295481The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
23957439The chemical basis of serine palmitoyltransferase inhibition by myriocin.J Am Chem Soc2013
23174186Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa.J Mol Biol2013
22106294Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales.Proc Natl Acad Sci U S A2012
21857666Mechanism of ubiquitylation by dimeric RING ligase RNF4.Nat Struct Mol Biol2011
20419351The Scottish Structural Proteomics Facility: targets, methods and outputs.J Struct Funct Genomics2010
20878961NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond.Angew Chem Int Ed Engl2010
20445930Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.Mol Biosyst2010
19182782AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.Nat Chem Biol2009
19739191Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).Chembiochem2009
19414020Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.J Mol Biol2009
19506028Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance.Nucleic Acids Res2009
18056710Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains.J Biol Chem2008
18781570Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog.Angew Chem Int Ed Engl2008
18997340Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase.Acta Crystallogr Sect F Struct Biol Cryst Commun2008
18510925Structure of the DNA repair helicase XPD.Cell2008
18379686Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras.Chem Commun (Camb)2008
18385152TarO: a target optimisation system for structural biology.Nucleic Acids Res2008
17554169Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase.Acta Crystallogr Sect F Struct Biol Cryst Commun2007
17565195Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase.Acta Crystallogr Sect F Struct Biol Cryst Commun2007
17559874The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.J Mol Biol2007
16511308Overexpression, purification, crystallization and data collection of Sulfolobus solfataricus Sso6206, a novel highly conserved protein.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
17077494Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
17012780Structure of the heterotrimeric PCNA from Sulfolobus solfataricus.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
16911956The structure and function of frataxin.Crit Rev Biochem Mol Biol2006
16413487Identification of a bacterial type III effector family with G protein mimicry functions.Cell2006
16170324The C-type lectin fold as an evolutionary solution for massive sequence variation.Nat Struct Mol Biol2005
11567154Molecular placement of experimental electron density: a case study on UDP-galactopyranose mutase.Acta Crystallogr D Biol Crystallogr2001
11320320Overexpression, purification, crystallization and data collection of 3-methylaspartase from Clostridium tetanomorphum.Acta Crystallogr D Biol Crystallogr2001
11573090UDP-galactopyranose mutase has a novel structure and mechanism.Nat Struct Biol2001
10089346Initiating a crystallographic study of UDP-galactopyranose mutase from Escherichia coli.Acta Crystallogr D Biol Crystallogr1999
10216322Initiating a crystallographic study of UDP-galactopyranose mutase from escherichia coli. erratumActa Crystallogr D Biol Crystallogr1999
10089454Purification, crystallization and preliminary structural studies of dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC), the third enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium.Acta Crystallogr D Biol Crystallogr1999
9757127Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis.Acta Crystallogr D Biol Crystallogr1998
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Collaborators

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College of Life Sciences, University of Dundee
Co-authored papers 6
University of California
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University of Toronto
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and the California NanoSystems Institute, University of California los angeles
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The Skaggs Institute for Chemical Biology, The Scripps Research Institute
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Lilly Research Laboratories
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University of Dundee
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University of California San Diego
Co-authored papers 1
University of California at San Francisco
Co-authored papers 1
University of Washington
Co-authored papers 1
Co-authored papers 1
University of Calgary
Co-authored papers 1
Universitat Pompeu Fabra (UPF)
Co-authored papers 1
Eastern University
Co-authored papers 1
University of California
Co-authored papers 1