Author details

Full Name

Michael R Hayden

Affiliation

ORCID

Career Start Year

1977

Papers

788

H Index

122

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36726088	Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models.		2023
35651273	Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease.	Antioxidants and Redox Signaling	2023
35507432	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.		2023
37597209	Preclinical Development and Characterization of Novel Adeno-Associated Viral Vectors for the Treatment of Lipoprotein Lipase Deficiency.		2023
37658843	Limitations of Dual-Single Guide RNA CRISPR Strategies for the Treatment of Central Nervous System Genetic Disorders.		2023
38092268	Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease.		2023
37468110	Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks.		2023
37020532	A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod.		2023
36711022	Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage.		2023
36958846	Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.		2023
37199581	Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice.	Aging Dis	2023
36811812	Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose.		2023
36944490	Axonal ER Ca Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model.		2023
35143966	Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice.	Neurobiology of Disease	2022
36107630	Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans.	J Clin Invest	2022
36075537	Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model.	Neurobiology of Disease	2022
35988447	Mitochondrial and redox modifications in early stages of Huntington's disease.	Redox Biology	2022
36442204	Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models.	Journal of Huntington's disease	2022
36523269	Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity.		2022
34753986	Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.	Scientific Reports	2021
33797036	The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.		2021
34092649	Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting.	Journal of Huntington's disease	2021
33871049	Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor.	Journal of Neurochemistry	2021
33556538	Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice.	Neurobiology of Disease	2021
33920913	Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases.	International Journal of Molecular Sciences	2021
33310753	Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.	Journal of Neuroscience	2021
32995944	Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [F] fluspidine and [F] fallypride PET study.	European Journal of Nuclear Medicine and Molecular Imaging	2021
34911927	Small molecule splicing modifiers with systemic HTT-lowering activity.	Nature Communications	2021
34390831	Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.	Neurobiology of Disease	2021
32661355	Tracing the mutated HTT and haplotype of the African ancestor who spread Huntington disease into the Middle East.	Genet Med	2020
31745548	Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.	Nucleic Acids Research	2020
32407769	Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease.	Neurobiology of Disease	2020
33207199	Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.	Cell Reports	2020
33098802	Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies.	Lancet Neurology, The	2020
33250715	DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease.	Frontiers in Cellular Neuroscience	2020
32978366	pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.	Cell Death Dis	2020
33192449	The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons.	Frontiers in Aging Neuroscience	2020
32741964	Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range.	Genetics in Medicine	2020
32622701	Compromised IGF signaling causes caspase-6 activation in Huntington disease.	Experimental Neurology	2020
32508327	Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease.	Journal of Huntington's disease	2020
33164941	Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study.	Journal of Huntington's disease	2020
30824685	Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 Model.	Cell Death and Disease	2019
32095771	Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices.	Digital Biomarkers	2019
31708117	A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.	American Journal of Human Genetics	2019
30594810	Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.	Neurobiology of Disease	2019
30575996	Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.	Movement Disorders	2019
30423259	Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.	FASEB Journal	2019
30334188	Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.	Molecular Neurobiology	2019
29999516	Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes.	Clin Pharmacol Ther	2019
30756361	Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.		2019