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Author Details

David H Spencer
Washington University School of Medicine.
2000
55
30
PMIDPaper TitleJournal TitlePublished Year
36351182Evaluation of Breast Implant-Associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing.Aesthet Surg J2023
37079859Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.JCO Precis Oncol2023
37339484Genomic landscape of TP53-mutated myeloid malignancies.Blood Adv2023
36711871Genomic landscape of <i>TP53</i> -mutated myeloid malignancies.medRxiv2023
36797416KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.Leukemia2023
34115842Heterozygous variants of CLPB are a cause of severe congenital neutropenia.Blood2022
35709710Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.Blood Cancer Discov2022
35650442Clonal dynamics of haematopoiesis across the human lifespan.Nature2022
35471774Clinical whole-genome sequencing in cancer diagnosis.Hum Mutat2022
35041928Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.J Mol Diagn2022
34873300Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.Leukemia2022
35196021Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia.Sci Transl Med2022
34670359Tumor suppressor function of <i>WT1</i> in acute promyelocytic leukemia.Haematologica2022
34788385DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.Blood2022
32398790Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells.Leukemia2021
33704937Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.N Engl J Med2021
34845035Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.Proc Natl Acad Sci U S A2021
34036230Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.JCO Precis Oncol2021
32818246Deletions in BCP-ALL result in a TAD more FLT3.Blood2020
31996479Remethylation of <i>Dnmt3a</i><sup>-/-</sup> hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.Proc Natl Acad Sci U S A2020
31685621Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.Proc Natl Acad Sci U S A2019
31812712Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.Exp Hematol2019
29365324Expression profiling of snoRNAs in normal hematopoiesis and AML.Blood Adv2018
29967526Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures.Pediatr Res2018
29634818Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.JAMA2018
29618788DNMT3A<sup>R882</sup>-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A<sup>R882C</sup> OCI-AML3 leukemia cell line.Blood Cancer J2018
28760689Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.Exp Hematol2017
28138153CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.Nat Genet2017
28215704CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.Cell2017
25345567Clinical next-generation sequencing in patients with non-small cell lung cancer.Cancer2015
26386089Occult Specimen Contamination in Routine Clinical Next-Generation Sequencing Testing.Am J Clin Pathol2015
26305651Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.JAMA2015
25995208Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856.Genetics2015
25600023Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.Leukemia2015
24211364Performance of common analysis methods for detecting low-frequency single nucleotide variants in targeted next-generation sequence data.J Mol Diagn2014
24613412Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.Cancer Cell2014
24656771The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.Cancer Cell2014
24211365Validation of a next-generation sequencing assay for clinical molecular oncology.J Mol Diagn2014
23297133Genomic impact of transient low-dose decitabine treatment on primary AML cells.Blood2013
24303327Clinical genomicist workstation.AMIA Jt Summits Transl Sci Proc2013
23634996Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.N Engl J Med2013
23810758Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.J Mol Diagn2013
23159595Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.J Mol Diagn2013
21059826Red cell transfusion decreases hemoglobin A1c in patients with diabetes.Clin Chem2011
22031306Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting.Am J Clin Pathol2011
21885623Direct-to-consumer genetic testing: reliable or risky?Clin Chem2011
19409521IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23.Am J Hum Genet2009
17493132Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients.Mol Microbiol2007
17033972Detecting disease-causing mutations in the human genome by haplotype matching.Am J Hum Genet2006
15743962Evidence for diversifying selection at the pyoverdine locus of Pseudomonas aeruginosa.J Bacteriol2005
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Collaborators

Timothy J Ley
Washington University School of Medicine
Co-authored papers 23
Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 16
Christopher A Miller
Washington University School of Medicine
Co-authored papers 15
Daniel C Link
Washington University School of Medicine
Co-authored papers 12
John F DiPersio
Washington University School of Medicine
Co-authored papers 11
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 11
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 10
Sharon E Heath
Washington University School of Medicine.
Co-authored papers 10
Peter Westervelt
Washington University School of Medicine
Co-authored papers 10
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 10
Maynard V Olson
University of Washington
Co-authored papers 8
Richard K Wilson
The Ohio State University
Co-authored papers 8
Lukas D Wartman
Washington University School of Medicine in St. Louis
Co-authored papers 7
Shashikant Kulkarni
Centene Center for Health Transformation, Centene Corporation
Co-authored papers 7
Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 7
Tamara L Lamprecht
St. Jude Children's Research Hospital
Co-authored papers 7
Malachi Griffith
Washington University
Co-authored papers 7
Obi L Griffith
Washington University
Co-authored papers 6
Elaine R Mardis
The Ohio State University
Co-authored papers 6
Jeffery M Klco
St. Jude Children's Research Hospital
Co-authored papers 6
Vincent Magrini
The Ohio State University
Co-authored papers 6
Matthew J Christopher
Washington University School of Medicine
Co-authored papers 5
Jason Walker
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 4
Shamika Ketkar
Co-authored papers 4
David E Larson
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 4
Rajinder Kaul
Altius Institute for Biomedical Sciences
Co-authored papers 4
Catherine E Cottrell
Nationwide Children's Hospital
Co-authored papers 4
Rakesh Nagarajan
Current or past members of the College of American Pathologists
Co-authored papers 3
Zachary L Skidmore
Washington University in St. Louis School of Medicine
Co-authored papers 3
Mark A Watson
Washington University School of Medicine
Co-authored papers 3
Release 1.2