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Author Details

Leslie W Chinn
Genentech Inc.
2003
29
16
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34042314Efficacy, Safety, and Pharmacodynamic Effects of the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Trial.Arthritis Rheumatol2021
34750553Fenebrutinib in H<sub>1</sub> antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial.Nat Med2021
31376152Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI.Clin Pharmacol Ther2020
31907670Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis [corrected].Pharm Res2020
31980965Correction to: Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis.Pharm Res2020
33139537Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans.Proc Natl Acad Sci U S A2020
32383787Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.CPT Pharmacometrics Syst Pharmacol2020
32270926Fenebrutinib versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial (ANDES Study).Arthritis Rheumatol2020
32535897Understanding the Effect of Hydroxypropyl-β-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.Clin Pharmacol Ther2020
31371481Absence of Pharmacokinetic Interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate.J Pharmacol Exp Ther2019
29484638Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC-0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor.Clin Pharmacol Ther2018
29522347In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound.Mol Pharm2018
28834434Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria.Mol Pharm2017
23187863An overview of transporter information in package inserts of recently approved new molecular entities.Pharm Res2013
23982262Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?Pharmacogenet Genomics2013
20216335Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).Pharmacogenet Genomics2011
21502085Genome-wide association study implicates PARD3B-based AIDS restriction.J Infect Dis2011
20877624Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.PLoS One2010
21083371Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection.J Infect Dis2010
20799350Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.Protein Sci2010
19295159Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila.J Neurosci2009
17940136The effects of ABCB1 3'-untranslated region variants on mRNA stability.Drug Metab Dispos2008
19096711Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults.PLoS One2008
18287207Substrate-dependent effects of human ABCB1 coding polymorphisms.J Pharmacol Exp Ther2008
18364470The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.J Pharmacol Exp Ther2008
17510066Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein.J Antimicrob Chemother2007
17259950ABCB1 pharmacogenetics: progress, pitfalls, and promise.Clin Pharmacol Ther2007
16507877PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.Pharmacol Rev2006
14706539A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions.Peptides2003
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