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Author Details

Patrick Kwok-Shing Ng
The University of Texas MD Anderson Cancer Center
1987
52
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37454202Actionability classification of variants of unknown significance correlates with functional effect.NPJ Precis Oncol2023
35138907A functional genomic approach to actionable gene fusions for precision oncology.Sci Adv2022
34108622Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutations.Oncogene2021
34638434<i>RAC1</i> Alterations Induce Acquired Dabrafenib Resistance in Association with Anaplastic Transformation in a Papillary Thyroid Cancer Patient.Cancers (Basel)2021
34779417Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.J Clin Invest2021
34507989Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases.Proc Natl Acad Sci U S A2021
34117033Clinical and Functional Characterization of Atypical <i>KRAS</i>/<i>NRAS</i> Mutations in Metastatic Colorectal Cancer.Clin Cancer Res2021
32540409Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations.J Thorac Oncol2020
32079540Comprehensive assessment of computational algorithms in predicting cancer driver mutations.Genome Biol2020
29533785Systematic Functional Annotation of Somatic Mutations in Cancer.Cancer Cell2018
30096302Comprehensive Characterization of Cancer Driver Genes and Mutations.Cell2018
30012111AKT isoform-specific expression and activation across cancer lineages.BMC Cancer2018
30389923Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.Nat Commun2018
30380420Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.Cell Rep2018
29353445Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis.Dig Dis Sci2018
29625053Comprehensive Characterization of Cancer Driver Genes and Mutations.Cell2018
29738578Cancer driver mutation prediction through Bayesian integration of multi-omic data.PLoS One2018
28528867A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.Cancer Cell2017
28500277Ba/F3 transformation assays.Oncotarget2017
28202507YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.Cancer Res2017
28984208Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening.BMC Genomics2017
28566428Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in <i>RAS</i> mutant cancers.Sci Transl Med2017
26979494Transcriptome analysis of different developmental stages of amphioxus reveals dynamic changes of distinct classes of genes during development.Sci Rep2016
25546157RET fusion as a novel driver of medullary thyroid carcinoma.J Clin Endocrinol Metab2015
25629879Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas.Nat Commun2015
25445830The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens.J Allergy Clin Immunol2015
24395800Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.Proc Natl Acad Sci U S A2014
25284480Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.Cancer Cell2014
25193510A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.Mol Cancer Ther2014
24871328A pan-cancer proteomic perspective on The Cancer Genome Atlas.Nat Commun2014
22565394Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines.Invest New Drugs2013
23619167Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.Cancer Discov2013
23169799Identification of small RNAs in Mycobacterium smegmatis using heterologous Hfq.RNA2013
23229819p63 regulates cell proliferation and cell cycle progressionâ¿¿associated genes in stromal cells of giant cell tumor of the bone.Int J Oncol2013
23347832Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells.FEBS Lett2013
23284286Insertion/deletion polymorphisms in the οNp63 promoter are a risk factor for bladder exstrophy epispadias complex.PLoS Genet2012
20886653Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.J Orthop Res2011
21814558The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity.PLoS One2011
21540083Characterization of human FHL2 transcript variants and gene expression regulation in hepatocellular carcinoma.Gene2011
21377781FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells.Cancer Lett2011
21119603FGF8b oncogene mediates proliferation and invasion of Epstein-Barr virus-associated nasopharyngeal carcinoma cells: implication for viral-mediated FGF8b upregulation.Oncogene2011
21057531Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.Oncogene2011
21130852The involvement of N-G,N-G-dimethyarginine dimethylhydrolase 1 in the proliferative effect of Astragali radix on cardiac cells.J Ethnopharmacol2011
20225273CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression.J Cell Biochem2010
20547241Transcriptional regulation and functional implication of the grass carp CITED1 (gcCITED1) in the negative regulation of HIF-1.Int J Biochem Cell Biol2010
19883516Functional characterization of two CITED3 homologs (gcCITED3a and gcCITED3b) in the hypoxia-tolerant grass carp, Ctenopharyngodon idellus.BMC Mol Biol2009
18945501Enhancement of hypoxia-induced gene expression in fish liver by the aryl hydrocarbon receptor (AhR) ligand, benzo[a]pyrene (BaP).Aquat Toxicol2008
17382971Characterization of a hypoxia-responsive leptin receptor (omLepR(L)) cDNA from the marine medaka (Oryzias melastigma).Mar Pollut Bull2007
16623959Cloning and expression analysis of two distinct HIF-alpha isoforms--gcHIF-1alpha and gcHIF-4alpha--from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus.BMC Mol Biol2006
16961934Hypoxia induces telomerase reverse transcriptase (TERT) gene expression in non-tumor fish tissues in vivo: the marine medaka (Oryzias melastigma) model.BMC Mol Biol2006
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Johns Hopkins University School of Medicine
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McDonnell Genome Institute, Washington University School of Medicine
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