Author details

Full Name

Manfred Gessler

Affiliation

ORCID

Career Start Year

1963

Papers

175

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37792584	TRIM28 inactivation in epithelial nephroblastoma is frequent and often associated with predisposing TRIM28 germline variants.	J Pathol	2024
37848532	Hallmark discoveries in the biology of Wilms tumour.	Nat Rev Urol	2024
36966138	Genomic characterization of DICER1-associated neoplasms uncovers molecular classes.	Nat Commun	2023
36592003	Tumor biology, biomarkers, and liquid biopsy in pediatric renal tumors.	Pediatr Blood Cancer	2023
34919667	The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.	Carcinogenesis	2022
35445187	The genomic landscape of pediatric renal cell carcinomas.	iScience	2022
34689785	MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates.	Cancer Cell International	2021
33479225	Sarcoma classification by DNA methylation profiling.	Nat Commun	2021
33520697	HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium.	Front Oncol	2021
33460450	Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93-01, 2001 and UK-IMPORT database: A report of the SIOP-Renal Tumor Study Group.	Int J Cancer	2021
34465197	[CME/Answers: Mushroom Poisoning in the Family Practice].	Praxis	2021
34831025	Correction: Welter et al. Characteristics of Nephroblastoma/Nephroblastomatosis in Children with a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome. <i>Cancers</i> 2021, <i>13</i>, 5016.	Cancers (Basel)	2021
34650095	Wilms tumour.	Nat Rev Dis Primers	2021
34638500	Characteristics of Nephroblastoma/Nephroblastomatosis in Children with a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome.	Cancers (Basel)	2021
32595505	Intensive Hemodiafiltration Successfully Removes Ganciclovir Overdose and Largely Exceeds Reported Elimination During Hemodialysis-A Case Report and Review of the Literature.	Frontiers in Pharmacology	2020
32267965	Less may be more for stage I epithelial Wilms tumors.	Cancer	2020
31562394	High-risk blastemal Wilms tumor can be modeled by 3D spheroid cultures in vitro.	Oncogene	2020
31043716	Publisher Correction: The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol.	Nat Rev Urol	2019
31708418	Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.	Cell Rep	2019
30155889	The role of TCF3 as potential master regulator in blastemal Wilms tumors.	Int J Cancer	2019
30367465	Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.	International Journal of Cancer	2019
30694527	TRIM28 haploinsufficiency predisposes to Wilms tumor.	Int J Cancer	2019
30745427	Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.	Development (Cambridge)	2019
31310235	The transcription factor Hey and nuclear lamins specify and maintain cell identity.	eLife	2019
29286563	ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.	Pediatr Blood Cancer	2018
30310143	The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol.	Nat Rev Urol	2018
29881993	Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.	Acta Neuropathol	2018
29915264	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.	Nat Commun	2018
29572501	Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information.	Mod Pathol	2018
29489754	The landscape of genomic alterations across childhood cancers.	Nature	2018
29741575	REGGAE: a novel approach for the identification of key transcriptional regulators.	Bioinformatics	2018
29085664	TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia.	J Pathol Clin Res	2017
28698213	Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels.	Science Signaling	2017
29089605	Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol.	Nat Rev Urol	2017
27731369	An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.	Scientific Reports	2016
27432915	Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.	J Clin Oncol	2016
26787660	Multi-omics enrichment analysis using the GeneTrail2 web service.	Bioinformatics	2016
27000436	Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story.	J Pathol	2016
27322654	The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation.	Nature Immunology	2016
27043538	Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes.	Int J Mol Sci	2016
26501925	DrugTargetInspector: An assistance tool for patient treatment stratification.	Int J Cancer	2016
26068074	Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.	PLoS One	2015
25749049	Multiple mechanisms of MYCN dysregulation in Wilms tumour.	Oncotarget	2015
25670083	Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.	Cancer Cell	2015
25446183	Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.	Journal of Molecular and Cellular Cardiology	2015
26183773	Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.	FASEB Journal	2015
24824468	[Adjustable transobturatoric sling system in men : diagnosis and therapy recommendations to persistent pain].	Der Urologe	2014
25248480	Hey bHLH transcription factors.	Current Topics in Developmental Biology	2014
24770533	GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.	Nature Communications	2014
25217524	The Notch pathway inhibits TGFÎ² signaling in breast cancer through HEYL-mediated crosstalk.	Cancer Res	2014