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Author Details

Pamela J McMillan
University of Washington
1993
32
19
PMIDPaper TitleJournal TitlePublished Year
36732296Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change.Brain2023
33184027Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.Neurobiol Dis2021
34187600Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.Acta Neuropathol Commun2021
33228809Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.Acta Neuropathol Commun2020
31034749Tau tubulin kinases in proteinopathy.FEBS J2019
31834878Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.PLoS Genet2019
31852801Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.Sci Transl Med2019
29409526Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.Mol Neurodegener2018
26777891Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction.Neuroscience2016
27473149The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.Acta Neuropathol2016
26041339High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration.Acta Neuropathol Commun2015
26076170R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.JAMA Neurol2015
25251220Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.PLoS One2014
25473830The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.PLoS Genet2014
23424178CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Ann Neurol2013
21147074Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.Brain Res2011
22002427Truncation of tau at E391 promotes early pathologic changes in transgenic mice.J Neuropathol Exp Neurol2011
20854651From model system to clinical medicine: pathophysiologic links of common proteinopathies.Alzheimers Res Ther2010
18925637Tau isoform regulation is region- and cell-specific in mouse brain.J Comp Neurol2008
17388944Proteomic identification of novel proteins in cortical lewy bodies.Brain Pathol2007
16515786Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.Exp Neurol2006
15751228Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque.J Neuropathol Exp Neurol2005
15465628Increased galanin receptor occupancy in Alzheimer's disease.Neurobiol Aging2004
15525338Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus.J Neurochem2004
12507914Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele.Am J Pathol2003
12106699Tamoxifen enhances choline acetyltransferase mRNA expression in rat basal forebrain cholinergic neurons.Brain Res Mol Brain Res2002
10891593Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease.Brain Res Mol Brain Res2000
9573399Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats.Brain Res1998
8774454The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat.J Neurosci1996
8918895Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease.J Histochem Cytochem1996
7731807Evidence for the requirement of protein synthesis and protein kinase activity in the temperature regulated stability of a Tetrahymena surface protein mRNA.Nucleic Acids Res1995
8414992rseB, a chromosomal locus that affects the stability of a temperature-specific surface protein mRNA in Tetrahymena thermophila.Nucleic Acids Res1993
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Collaborators

James B Leverenz
Lou Ruvo Center for Brain Health, Cleveland Clinic
Co-authored papers 16
Christopher Dirk Keene
University of Washington
Co-authored papers 8
Gerard D Schellenberg
Co-authored papers 6
Thomas D Bird
University of Washington School of Medicine
Co-authored papers 6
Caitlin S Latimer
University of Washington
Co-authored papers 4
Thomas J Montine
Stanford University
Co-authored papers 3
Virginia M-Y Lee
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
John Q Trojanowski
University of Pennsylvania
Co-authored papers 2
Kostantin Kiianitsa
University of Washington
Co-authored papers 1
Santhosh Girirajan
The Huck Institutes of Life Sciences, University Park, Pennsylvania State University
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Sarah J Benbow
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Malia Rumbaugh
Indiana University School of Medicine
Co-authored papers 1
Michael O Dorschner
University of Washington
Co-authored papers 1
Zoran Brkanac
University of Washington
Co-authored papers 1
Mark Matsushita
University of Washington
Co-authored papers 1
Wendy H Raskind
University of Washington School of Medicine
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Chang-En Yu
and Clinical Center
Co-authored papers 1
Gwenn A Garden
University of Washington School of Medicine
Co-authored papers 1
Suman Jayadev
University of Washington
Co-authored papers 1
Irina Kurtz
University of Washington
Co-authored papers 1
Olena Korvatska
University of Washington
Co-authored papers 1
Xindi Guo
Sage Bionetworks, University of Washington
Co-authored papers 1
Li-San Wang
Co-authored papers 1
Release 1.2