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Author Details

Alexey Bochkarev
University of Toronto
1990
51
32
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
22649097Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.Sci Signal2012
22952628Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.PLoS One2012
19187036Circular dichroism spectra and electrophoretic mobility shift assays show that human replication protein A binds and melts intramolecular G-quadruplex structures.Biochemistry2009
19089949An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.Proteins2009
18186464First crystallographic models of human TBC domains in the context of a family-wide structural analysis.Proteins2008
18542887High throughput crystallography at SGC Toronto: an overview.Methods Mol Biol2008
18285338Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.J Biol Chem2008
17243178Structural basis of allele variation of human thiopurine-S-methyltransferase.Proteins2007
17982461In situ proteolysis for protein crystallization and structure determination.Nat Methods2007
17253903The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA.PLoS Biol2007
17355872Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.Structure2007
17410582Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.Proteins2007
17426033Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator.J Biol Chem2007
17125854Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.Mol Biochem Parasitol2007
16384583An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex.J Mol Biol2006
17139255Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA.EMBO J2006
16804942Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).Proteins2006
16946699Structural basis for molecular recognition and presentation of histone H3 by WDR5.EMBO J2006
16481746p53 transcriptional activation domain: a molecular chameleon?Cell Cycle2006
16598263Crystal structure of the CorA Mg2+ transporter.Nature2006
16546208Structural and biochemical study of effector molecule recognition by the E.coli glyoxylate and allantoin utilization regulatory protein AllR.J Mol Biol2006
16575881Effects of ssDNA sequences on non-sequence-specific protein binding.Chirality2006
15701634The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.J Biol Chem2005
16234232Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A.Proc Natl Acad Sci U S A2005
15102447From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold.Curr Opin Struct Biol2004
15047856Human replication protein A (RPA) binds a primer-template junction in the absence of its major ssDNA-binding domains.Nucleic Acids Res2004
150643602'-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro.Nucleic Acids Res2004
12881520Independent and coordinated functions of replication protein A tandem high affinity single-stranded DNA binding domains.J Biol Chem2003
11927569Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA.EMBO J2002
12414967Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).J Virol2002
11157767Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding.EMBO J2001
10827167Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.J Biol Chem2000
12760033Three-dimensional structure and function of replication protein A.Cold Spring Harb Symp Quant Biol2000
10856290The role for zinc in replication protein A.J Biol Chem2000
11081631Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.Cell2000
10449415The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding.EMBO J1999
9519296Origin DNA-binding proteins.Curr Opin Struct Biol1998
9461578The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.J Biol Chem1998
9878348The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1.J Mol Biol1998
8990123Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.Nature1997
8995279Replication protein A. Characterization and crystallization of the DNA binding domain.J Biol Chem1997
8625416Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA.Cell1996
7657632Overexpression, purification, and crystallization of the DNA binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1.J Biol Chem1995
8540318A new way of looking at aspartic proteinase structures: a comparison of pepsin structure to other aspartic proteinases in the near active site region.Adv Exp Med Biol1995
7763319[X-ray structural study of 3'-O-methylthiomethylthymidine and 3'-O-methylsulfinylmethylthymidine--potential inhibitors of HIV].Bioorg Khim1995
7869382The mechanism of protein crystal growth from lipid layers.J Mol Biol1995
7553871Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1.Cell1995
12818823'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties.J Med Chem1992
1445432[Molecular and crystalline structure of 3'-methylamino-2',3'-dideoxyribosylthymine--a potential inhibitor of HIV].Bioorg Khim1992
1841310Structure and biological activity correlation for some nucleoside analogues-inhibitors of reproduction of human immunodeficiency virus (HIV-1).Nucleic Acids Symp Ser1991
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Collaborators

University of Toronto
Co-authored papers 17
University of Toronto
Co-authored papers 9
Central China Normal University
Co-authored papers 5
University of Toronto
Co-authored papers 4
and Center for Structural Biology, Vanderbilt University
Co-authored papers 3
University of Toronto
Co-authored papers 3
Kangwon National University College of Medicine
Co-authored papers 2
University of Toronto
Co-authored papers 2
University of Toronto
Co-authored papers 2
the Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 2
University of Windsor
Co-authored papers 2
Ecole Polytechnique Federale de Lausanne, Global Health Institute
Co-authored papers 2
Dana-Farber Cancer Institute
Co-authored papers 2
Miami University
Co-authored papers 1
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 1
University of South Carolina, Michigan State University
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Co-authored papers 1
Karolinska Institutet, BioClinicum J6
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
College Street, University of Toronto
Co-authored papers 1
The Rockefeller University
Co-authored papers 1
University of Calgary, 0 Hospital Drive NW
Co-authored papers 1
MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh
Co-authored papers 1
EMBL--European Bioinformatics Institute
Co-authored papers 1
Pacific Northwest National Laboratory
Co-authored papers 1
Miguel Hernandez University of Elche.
Co-authored papers 1
Co-authored papers 1