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Author Details

Alan J Knox
Nottingham NIHR Biomedical Research Centre
1986
221
54
PMIDPaper TitleJournal TitlePublished Year
34518117Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis.J Cyst Fibros2022
35113780<i>Porphyromonas pasteri</i> and <i>Prevotella nanceiensis</i> in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.J Med Microbiol2022
345960132-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent <i>Pseudomonas aeruginosa</i> burden in adults with cystic fibrosis.J Med Microbiol2021
33008450TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.Clin Epigenetics2020
30414795Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma.Chest2019
31671047Clinical significance of <i>Pseudomonas aeruginosa</i> 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.J Med Microbiol2019
31595000Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.Sci Rep2019
29053336Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis.Am J Respir Cell Mol Biol2018
29555582Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.Biochim Biophys Acta Gene Regul Mech2018
29527240Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.Clin Epigenetics2018
29305433PINX1 and TERT Are Required for TNF-α-Induced Airway Smooth Muscle Chemokine Gene Expression.J Immunol2018
27773591Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study.J Cyst Fibros2017
28225294Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis.Am J Respir Cell Mol Biol2017
29079141Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study; response to comments.J Cyst Fibros2017
28852645Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis.ERJ Open Res2017
28850106FANTOM5 CAGE profiles of human and mouse samples.Sci Data2017
28068000sTREM-1 is elevated in cystic fibrosis and correlates with proteases.Pediatr Pulmonol2017
26709241Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial.Pediatr Pulmonol2016
26418236Matrix metalloproteinases -8 and -9 in the Airways, Blood and Urine During Exacerbations of COPD.COPD2016
26282839The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison.J Cyst Fibros2016
27613847Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.Oncotarget2016
27811142Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.Sci Signal2016
27655795The differential effects of azithromycin on the airway epithelium in vitro and in vivo.Physiol Rep2016
27240956Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells.Biochem Biophys Res Commun2016
27560168Evaluation of the PPAR-γ Agonist Pioglitazone in Mild Asthma: A Double-Blind Randomized Controlled Trial.PLoS One2016
26861876Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.J Biol Chem2016
25673981Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial.Int J Chron Obstruct Pulmon Dis2015
26357963Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.Eur Respir J2015
26275100Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall.J Vis Exp2015
26619903Investigating NF-κB signaling in lung fibroblasts in 2D and 3D culture systems.Respir Res2015
26047642Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells.Am J Physiol Lung Cell Mol Physiol2015
26062683Accelerated extracellular matrix turnover during exacerbations of COPD.Respir Res2015
26084959Prostanoids as anti-inflammatory therapy: separating the good from the bad.Thorax2015
26164539Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders.Clin Biochem2015
25833917Corrigendum. Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.Am J Physiol Lung Cell Mol Physiol2015
26022946Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.Eur Respir J2015
25713319CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.Am J Physiol Lung Cell Mol Physiol2015
24652950A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.FASEB J2014
25339175Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.J Biol Chem2014
24793171Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.Am J Physiol Lung Cell Mol Physiol2014
24925127A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells.Biofabrication2014
24588862Mast cell migration to airway smooth muscle in asthma. Can we Gro(w) something to block the attraction?Clin Exp Allergy2014
24670764A promoter-level mammalian expression atlas.Nature2014
24628276Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation.Mol Pharm2014
22958983Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.J Cyst Fibros2013
24058568Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis.PLoS One2013
22246000Ciclesonide inhibits TNFα- and IL-1β-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells.Am J Physiol Lung Cell Mol Physiol2012
22992725Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer.J Biol Chem2012
23023969Future bronchodilator therapy: a bitter pill to swallow?Am J Physiol Lung Cell Mol Physiol2012
23118416Inhibition of polyadenylation reduces inflammatory gene induction.RNA2012
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Collaborators

Michael S Kobor
University of British Columbia
Co-authored papers 3
Tony J Kenna
Queensland University of Technology
Co-authored papers 2
Roberto Verardo
LNCIB - Consorzio Interuniversitario per le Biotecnologie c/o BIC Incubatori FVG
Co-authored papers 2
Thierry Sengstag
University of Basel
Co-authored papers 2
Hiroshi Ohno
RIKEN Center for Integrative Medical Sciences
Co-authored papers 2
Dan Goldowitz
University of British Columbia
Co-authored papers 2
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Shigeo Koyasu
RIKEN Center for Integrative Medical Sciences (IMS)
Co-authored papers 2
Michael Detmar
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 2
Peter Zhang
Child and Family Research Institute, University of British Columbia
Co-authored papers 2
Naoto Kondo
Nagoya City University Graduate School of Medical Sciences
Co-authored papers 2
Takaaki Sugiyama
Co-authored papers 2
Jun Furusawa
Aichi Cancer Center Hospital
Co-authored papers 2
Guojun Sheng
International Research Center for Medical Sciences (IRCMS), Kumamoto University
Co-authored papers 2
Yosuke Mizuno
Yokohama National University
Co-authored papers 2
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 2
Stefano Gustincich
Istituto Italiano di Tecnologia
Co-authored papers 2
Yuki I Kawamura
Research Institute, National Center for Global Health and Medicine
Co-authored papers 2
Reto Guler
International Centre for Genetic Engineering and Biotechnology
Co-authored papers 2
Albert S B Edge
Harvard Medical School
Co-authored papers 2
Christophe Simon
RIKEN Yokohama Institute
Co-authored papers 2
Peter Heutink
German Center for Neurodegenerative Diseases (DZNE).
Co-authored papers 2
Ernst J Wolvetang
Australian Institute for Bioengineering and Nanotechnology, University of Queensland
Co-authored papers 2
Suzana Savvi
South African Medical Research Council (SAMRC), University of Cape Town
Co-authored papers 2
Soichi Ogishima
Tohoku University Graduate School of Medicine
Co-authored papers 2
Christine L Mummery
Leiden University Medical Center
Co-authored papers 2
Weonju Lee
Kyungpook National University, Kyungpook National University Hospital
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Yohei Yonekura
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Release 1.2