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Author Details

Shenghua Wen
Oncology R&D
2001
18
13
PMIDPaper TitleJournal TitlePublished Year
37380821A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models.AAPS J2023
34890209Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes.Mol Pharm2022
33495510Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy.Commun Biol2021
33858425The biological function and clinical significance of STIL in osteosarcoma.Cancer Cell Int2021
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
30872381Modeling Dose and Schedule Effects of AZD2811 Nanoparticles Targeting Aurora B Kinase for Treatment of Diffuse Large B-cell Lymphoma.Mol Cancer Ther2019
28986473Mouse Red Blood Cell-Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate.Drug Metab Dispos2017
28292940Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.Mol Cancer Ther2017
27573426AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.Mol Cancer Ther2016
26291341Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.J Med Chem2015
23558446Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer.Mol Pharmacol2013
19626278Development of a new fully human anti-CD20 monoclonal antibody for the treatment of B-cell malignancies.Invest New Drugs2010
20053776A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models.Mol Cancer Ther2010
16897318Longitudinally quantitative 2-deoxy-2-[18F]fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: a case study with bortezomib in prostate cancer murine model.Mol Imaging Biol2006
16032708Spiculated periosteal response induced by intraosseous injection of 22Rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer patients.Prostate2005
15520207A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer.Cancer Res2004
11485908Ganglioside GM2/GD2 synthetase mRNA is a marker for detection of infrequent neuroblastoma cells in bone marrow.Am J Pathol2001
11274365PTEN controls tumor-induced angiogenesis.Proc Natl Acad Sci U S A2001
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Collaborators

Eric Gangl
Oncology R&D
Co-authored papers 4
Deborah Lawson
Oncology R&D
Co-authored papers 3
Ammar Adam
Oncology R&D
Co-authored papers 3
Francis D Gibbons
Preclinical and Translational Sciences, Inc.
Co-authored papers 3
Jamal C Saeh
Oncology R&D
Co-authored papers 3
Edward J Hennessy
Oncology R&D
Co-authored papers 3
Stephen Fawell
Oncology R&D
Co-authored papers 3
Alwin G Schuller
Oncology R&D
Co-authored papers 3
Justin Cidado
Oncology R&D
Co-authored papers 3
Michael Zinda
Repare Therapeutics Inc.
Co-authored papers 2
J Paul Secrist
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Co-authored papers 2
Barry R Davies
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Co-authored papers 2
Martin Wild
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Co-authored papers 2
Paula Lewis
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Co-authored papers 2
Kate F Byth
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Co-authored papers 2
William McCoull
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Co-authored papers 2
Gareth P Gregory
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 1
Terry MacIntyre
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Nancy Su
Co-authored papers 1
Joseph B Bolen
University of California San Francisco
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Patricia Jaaks
Wellcome Sanger Institute
Co-authored papers 1
Dave S B Hoon
Saint John's Cancer Institute at Saint John's Health Center
Co-authored papers 1
Nicholas K Tonks
University of Washington
Co-authored papers 1
Austin Dulak
Co-authored papers 1
Charles Patrick Reynolds
Cancer Center, Texas Tech University Health Sciences Center
Co-authored papers 1
Stephanos Ioannidis
H3 Biomedicine Inc.
Co-authored papers 1
Steven W Criscione
Oncology R&D
Co-authored papers 1
Kathleen Burke
Oncology R&D
Co-authored papers 1
Ricky W Johnstone
The University of Melbourne
Co-authored papers 1
Release 1.2